@article{e9e459c4b852411996bbca99821468eb,
title = "Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms",
abstract = "Due to their similarities in anatomy, physiology, and pharmacology to humans, mice are a valuable model system to study the generation and mechanisms modulating conventional outflow resistance and thus intraocular pressure. In addition, mouse models are critical for understanding the complex nature of conventional outflow homeostasis and dysfunction that results in ocular hypertension. In this review, we describe a set of minimum acceptable standards for developing, characterizing, and utilizing mouse models of open-angle ocular hypertension. We expect that this set of standard practices will increase scientific rigor when using mouse models and will better enable researchers to replicate and build upon previous findings.",
keywords = "mouse model, conventional outflow, glaucoma, intraocular pressure, ocular hypertension, outflow facility, Glaucoma, Conventional outflow, Ocular hypertension, Mouse model, Outflow facility, Intraocular pressure, Ocular Hypertension/metabolism, Trabecular Meshwork/metabolism, Consensus, Animals, Intraocular Pressure/physiology, Aqueous Humor/physiology, Tonometry, Ocular, Mice, Glaucoma/metabolism, Disease Models, Animal",
author = "McDowell, {Colleen M} and Krishnakumar Kizhatil and Elliott, {Michael H} and Overby, {Darryl R} and {van Batenburg-Sherwood}, Joseph and Millar, {J Cameron} and Kuehn, {Markus H} and Gulab Zode and Acott, {Ted S} and Anderson, {Michael G} and Bhattacharya, {Sanjoy K} and Bertrand, {Jacques A} and Terete Borras and Bovenkamp, {Diane E} and Lin Cheng and John Danias and {De Ieso}, {Michael Lucio} and Yiqin Du and Faralli, {Jennifer A} and Rudolf Fuchshofer and Ganapathy, {Preethi S} and Haiyan Gong and Samuel Herberg and Humberto Hernandez and Peter Humphries and John, {Simon W M} and Kaufman, {Paul L} and Keller, {Kate E} and Kelley, {Mary J} and Kelly, {Ruth A} and David Krizaj and Ajay Kumar and Leonard, {Brian C} and Lieberman, {Raquel L} and Paloma Liton and Yutao Liu and Liu, {Katy C} and Lopez, {Navita N} and Weiming Mao and Timur Mavlyutov and Fiona McDonnell and McLellan, {Gillian J} and Philip Mzyk and Andrews Nartey and Pasquale, {Louis R} and Patel, {Gaurang C} and Pattabiraman, {Padmanabhan P} and Peters, {Donna M} and Vijaykrishna Raghunathan and Willoughby, {Colin E}",
note = "Funding Information: The authors thank Aerie Pharmaceuticals, Inc.; Aerpio Pharmaceuticals, Inc.; Allergan; Bausch + Lomb; BrightFocus Foundation; Glaucoma Research Foundation; Glaukonix, Inc.; Glaukos Corp.; Nicox Visible Science; Novartis Pharmaceuticals, Inc.; Regeneron Pharmaceuticals; Santen, Inc.; and the Western Glaucoma Foundation for continued support of the trabecular meshwork study club, enabling 20 annual scientific gatherings of researchers dedicated to better understanding trabecular meshwork biology and facilitating the assembly of this position paper. The authors also thank BrightFocus Foundation for supporting the virtual trabecular meshwork study club meeting to enable continuous discussion among researchers throughout the COVID-19 pandemic. The contents of this manuscript do not represent the views of the U.S. Department of Veterans Affairs or the U.S. Government. Publisher Copyright: Copyright 2022 The Authors",
year = "2022",
month = feb,
day = "7",
doi = "10.1167/iovs.63.2.12",
language = "English",
volume = "63",
pages = "1--17",
journal = "INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE",
issn = "0146-0404",
publisher = "Association for Research in Vision and Ophthalmology",
number = "2",
}