Concepts of advanced therapeutic delivery systems for the management of remodeling and inflammation in airway diseases

Daljeet Singh Dhanjal; Parvarish Sharma; Meenu Mehta; Murtaza M Tambuwala; Parteek Prasher; Keshav R Paudel; Gang Liu; Shakti D Shukla; Philip M Hansbro; Dinesh Kumar Chellappan; Kamal Dua; Saurabh Satija

doi:10.4155/fmc-2021-0081

Concepts of advanced therapeutic delivery systems for the management of remodeling and inflammation in airway diseases

Daljeet Singh Dhanjal
, Parvarish Sharma
, Meenu Mehta
, Murtaza M Tambuwala
, Parteek Prasher
, Keshav R Paudel
, Gang Liu
, Shakti D Shukla
, Philip M Hansbro
, Dinesh Kumar Chellappan
, Kamal Dua
, Saurabh Satija

Research output: Contribution to journal › Review article › peer-review

23 Citations (Scopus)

149 Downloads (Pure)

Abstract

Chronic respiratory disorders affect millions of people worldwide. Pathophysiological changes to the normal airway wall structure, including changes in the composition and organization of its cellular and molecular constituents, are referred to as airway remodeling. The inadequacy of effective treatment strategies and scarcity of novel therapies available for the treatment and management of chronic respiratory diseases have given rise to a serious impediment in the clinical management of such diseases. The progress made in advanced drug delivery, has offered additional advantages to fight against the emerging complications of airway remodeling. This review aims to address the gaps in current knowledge about airway remodeling, the relationships between remodeling, inflammation, clinical phenotypes and the significance of using novel drug delivery methods.

Original language	English
Pages (from-to)	271-288
Number of pages	18
Journal	Future Medicinal Chemistry
Volume	14
Issue number	4
DOIs	https://doi.org/10.4155/fmc-2021-0081
Publication status	Published (in print/issue) - 12 Jan 2022

Bibliographical note

Funding Information:
PM Hansbro is funded by a fellowship and grants from the National Health and Medical Research Council (NHMRC) of Australia (1175134) and by UTS. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.

Publisher Copyright:
© 2022 Saurabh Satija.

Funding

Funding Information: PM Hansbro is funded by a fellowship and grants from the National Health and Medical Research Council (NHMRC) of Australia (1175134) and by UTS. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript. Publisher Copyright: © 2022 Saurabh Satija.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

inflammation
therapeutic interventions
respiratory diseases
COPD
NDDS
remodeling
respiratory disorders
Review
Humans
Administration, Inhalation
Inflammation/metabolism
Lung/anatomy & histology
Pulmonary Disease, Chronic Obstructive/therapy
Airway Remodeling
Drug Carriers/chemistry
Medication Adherence
Asthma/therapy

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10.4155/fmc-2021-0081Licence: CC BY

fmc-2021-0081Final published version, 5.19 MBLicence: CC BY

Cite this

Dhanjal, D. S., Sharma, P., Mehta, M., Tambuwala, M. M., Prasher, P., Paudel, K. R., Liu, G., Shukla, S. D., Hansbro, P. M., Chellappan, D. K., Dua, K., & Satija, S. (2022). Concepts of advanced therapeutic delivery systems for the management of remodeling and inflammation in airway diseases. Future Medicinal Chemistry, 14(4), 271-288. https://doi.org/10.4155/fmc-2021-0081

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abstract = "Chronic respiratory disorders affect millions of people worldwide. Pathophysiological changes to the normal airway wall structure, including changes in the composition and organization of its cellular and molecular constituents, are referred to as airway remodeling. The inadequacy of effective treatment strategies and scarcity of novel therapies available for the treatment and management of chronic respiratory diseases have given rise to a serious impediment in the clinical management of such diseases. The progress made in advanced drug delivery, has offered additional advantages to fight against the emerging complications of airway remodeling. This review aims to address the gaps in current knowledge about airway remodeling, the relationships between remodeling, inflammation, clinical phenotypes and the significance of using novel drug delivery methods.",

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KW - Drug Carriers/chemistry

KW - Medication Adherence

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Concepts of advanced therapeutic delivery systems for the management of remodeling and inflammation in airway diseases

Abstract

Bibliographical note

Funding

UN SDGs

Keywords

Access to Document

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