Concepts of advanced therapeutic delivery systems for the management of remodeling and inflammation in airway diseases

Daljeet Singh Dhanjal, Parvarish Sharma, Meenu Mehta, Murtaza M Tambuwala, Parteek Prasher, Keshav R Paudel, Gang Liu, Shakti D Shukla, Philip M Hansbro, Dinesh Kumar Chellappan, Kamal Dua, Saurabh Satija

Research output: Contribution to journalReview articlepeer-review

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Abstract

Chronic respiratory disorders (CRDs) affect millions of people worldwide. Pathophysiological changes to the normal airway wall structure, including changes in the composition and organization of its cellular and molecular constituents, are referred to as airway remodeling. The inadequacy of effective treatment strategies and scarcity of novel therapies available for the treatment and management of chronic respiratory diseases have given rise to a serious impediment in the clinical management of such diseases. The progress made in advanced drug delivery, has offered additional advantages to fight against the emerging complications of airway remodeling. This review aims to address the gaps in current knowledge about airway remodeling, the relationships between remodeling, inflammation, clinical phenotypes and the significance of using novel drug delivery methods.

Original languageEnglish
Pages (from-to)1-18
Number of pages18
JournalFuture Medicinal Chemistry
Early online date12 Jan 2022
DOIs
Publication statusE-pub ahead of print - 12 Jan 2022

Keywords

  • inflammation
  • therapeutic interventions
  • respiratory diseases
  • COPD
  • NDDS
  • remodeling
  • respiratory disorders

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