Comparison of the independent and combined metabolic effects of subchronic modulation of CCK and GIP receptor action in obesity-related diabetes

Nigel Irwin, IA Montgomery, Finbarr O'Harte, P Frizelle, Peter Flatt

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

OBJECTIVE: Compromise of gastric inhibitory polypeptide (GIP) receptor action and activation of cholecystokinin (CCK) receptors represent mechanistically different approaches to the possible treatment of obesity-related diabetes. In the present study, we have compared the individual and combined effects of (Pro3)GIP[mPEG] and (pGlu-Gln)-CCK-8 as an enzymatically stable GIP receptor antagonist and CCK receptor agonist molecule, respectively.RESULTS: Twice-daily injections of (pGlu-Gln)-CCK-8 alone and in combination with (Pro3)GIP[mPEG] in high-fat-fed mice for 34 days significantly decreased the energy intake throughout the entire study (P
Original languageEnglish
Pages (from-to)1058-1063
JournalInternational Journal of Obesity
Volume37
Issue number8
DOIs
Publication statusPublished - 20 Nov 2012

Fingerprint Dive into the research topics of 'Comparison of the independent and combined metabolic effects of subchronic modulation of CCK and GIP receptor action in obesity-related diabetes'. Together they form a unique fingerprint.

Cite this