Comparison of the independent and combined metabolic effects of subchronic modulation of CCK and GIP receptor action in obesity-related diabetes

Nigel Irwin; IA Montgomery; Finbarr O'Harte; P Frizelle; Peter Flatt

doi:10.1038/ijo.2012.179

Comparison of the independent and combined metabolic effects of subchronic modulation of CCK and GIP receptor action in obesity-related diabetes

Nigel Irwin, IA Montgomery, Finbarr O'Harte, P Frizelle, Peter Flatt

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

OBJECTIVE: Compromise of gastric inhibitory polypeptide (GIP) receptor action and activation of cholecystokinin (CCK) receptors represent mechanistically different approaches to the possible treatment of obesity-related diabetes. In the present study, we have compared the individual and combined effects of (Pro3)GIP[mPEG] and (pGlu-Gln)-CCK-8 as an enzymatically stable GIP receptor antagonist and CCK receptor agonist molecule, respectively.RESULTS: Twice-daily injections of (pGlu-Gln)-CCK-8 alone and in combination with (Pro3)GIP[mPEG] in high-fat-fed mice for 34 days significantly decreased the energy intake throughout the entire study (P

Original language	English
Pages (from-to)	1058-1063
Journal	International Journal of Obesity
Volume	37
Issue number	8
DOIs	https://doi.org/10.1038/ijo.2012.179
Publication status	Published (in print/issue) - 20 Nov 2012

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1038/ijo.2012.179

Cite this

@article{5f997d5486604edaa2395cf7ac944f6f,

title = "Comparison of the independent and combined metabolic effects of subchronic modulation of CCK and GIP receptor action in obesity-related diabetes",

abstract = "OBJECTIVE: Compromise of gastric inhibitory polypeptide (GIP) receptor action and activation of cholecystokinin (CCK) receptors represent mechanistically different approaches to the possible treatment of obesity-related diabetes. In the present study, we have compared the individual and combined effects of (Pro3)GIP[mPEG] and (pGlu-Gln)-CCK-8 as an enzymatically stable GIP receptor antagonist and CCK receptor agonist molecule, respectively.RESULTS: Twice-daily injections of (pGlu-Gln)-CCK-8 alone and in combination with (Pro3)GIP[mPEG] in high-fat-fed mice for 34 days significantly decreased the energy intake throughout the entire study (P",

author = "Nigel Irwin and IA Montgomery and Finbarr O'Harte and P Frizelle and Peter Flatt",

year = "2012",

month = nov,

day = "20",

doi = "10.1038/ijo.2012.179",

language = "English",

volume = "37",

pages = "1058--1063",

journal = "International Journal of Obesity",

issn = "1476-5497",

publisher = "Springer Nature",

number = "8",

}

TY - JOUR

T1 - Comparison of the independent and combined metabolic effects of subchronic modulation of CCK and GIP receptor action in obesity-related diabetes

AU - Irwin, Nigel

AU - Montgomery, IA

AU - O'Harte, Finbarr

AU - Frizelle, P

AU - Flatt, Peter

PY - 2012/11/20

Y1 - 2012/11/20

N2 - OBJECTIVE: Compromise of gastric inhibitory polypeptide (GIP) receptor action and activation of cholecystokinin (CCK) receptors represent mechanistically different approaches to the possible treatment of obesity-related diabetes. In the present study, we have compared the individual and combined effects of (Pro3)GIP[mPEG] and (pGlu-Gln)-CCK-8 as an enzymatically stable GIP receptor antagonist and CCK receptor agonist molecule, respectively.RESULTS: Twice-daily injections of (pGlu-Gln)-CCK-8 alone and in combination with (Pro3)GIP[mPEG] in high-fat-fed mice for 34 days significantly decreased the energy intake throughout the entire study (P

AB - OBJECTIVE: Compromise of gastric inhibitory polypeptide (GIP) receptor action and activation of cholecystokinin (CCK) receptors represent mechanistically different approaches to the possible treatment of obesity-related diabetes. In the present study, we have compared the individual and combined effects of (Pro3)GIP[mPEG] and (pGlu-Gln)-CCK-8 as an enzymatically stable GIP receptor antagonist and CCK receptor agonist molecule, respectively.RESULTS: Twice-daily injections of (pGlu-Gln)-CCK-8 alone and in combination with (Pro3)GIP[mPEG] in high-fat-fed mice for 34 days significantly decreased the energy intake throughout the entire study (P

U2 - 10.1038/ijo.2012.179

DO - 10.1038/ijo.2012.179

M3 - Article

SN - 1476-5497

VL - 37

SP - 1058

EP - 1063

JO - International Journal of Obesity

JF - International Journal of Obesity

IS - 8

ER -

Comparison of the independent and combined metabolic effects of subchronic modulation of CCK and GIP receptor action in obesity-related diabetes

Abstract

UN SDGs

Access to Document

Fingerprint

Cite this