Abstract
| Language | English |
|---|---|
| Pages | 499-504 |
| Journal | International Journal of Antimicrobial Agents |
| Volume | 32 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Dec 2008 |
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Keywords
- Hospital-acquired MRSA
- Antibiotic resistance
- Infection control practices
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Comparison of the effect of ciprofloxacin and Tazocin (R) on the incidence of meticillin-resistant Staphylococcus aureus (MRSA) in an Intensive Care Unit. / Aldeyab, Mamoon A.; Hughes, Carmel M.; Kearney, Mary P.; Scott, Michael G.; McDowell, DA; Hanley, Joanne; McMahon, MAS; Elshibly, Salah M.; Bailie, Ronald; McElnay, James C.
In: International Journal of Antimicrobial Agents, Vol. 32, No. 6, 12.2008, p. 499-504.Research output: Contribution to journal › Article
TY - JOUR
T1 - Comparison of the effect of ciprofloxacin and Tazocin (R) on the incidence of meticillin-resistant Staphylococcus aureus (MRSA) in an Intensive Care Unit
AU - Aldeyab, Mamoon A.
AU - Hughes, Carmel M.
AU - Kearney, Mary P.
AU - Scott, Michael G.
AU - McDowell, DA
AU - Hanley, Joanne
AU - McMahon, MAS
AU - Elshibly, Salah M.
AU - Bailie, Ronald
AU - McElnay, James C.
PY - 2008/12
Y1 - 2008/12
N2 - Meticillin-resistant Staphylococcus aureus (MRSA) is a very significant agent of recalcitrant healthcare-associated infections. A major risk of acquiring such infections is thought to be modulated by the use of particular antimicrobial therapies. The aim of this research was to evaluate prospectively the impact of using either ciprofloxacin or Tazocin (R) (piperacillin + tazobactam) on the incidence of MRSA in an Intensive Care Unit (ICU). The 1-year (2 x 6 months) cross-over study was carried out in a medium-sized (426 beds) teaching hospital. During the first 6-month period, ciprofloxacin was used as the first-line broad-spectrum antibiotic therapy of choice. During the second 6-month period, Tazocin (R) was used as first-line therapy. The incidence of hospital-acquired MRSA (i.e. colonised and/or infected) and rates of compliance of the ICU healthcare workers to optimal hand hygiene practices were recorded throughout the study. The study observed no statistically significant differences (P = 0.1) between MRSA incidence rates in the ICU during the ciprofloxacin (4.4/1000 bed-days) or Tazocin (R) (11.4/1000 bed- days) arms of the study. Interestingly, observing healthcare workers' hand hygiene practices throughout the entire study showed that healthcare workers adhered to these practices 59.2% of the time during the ciprofloxacin arm and 66.0% during the Tazocin (R) arm. The low incidence rates within the unit demonstrated the importance of infection control in limiting the spread of MRSA despite the extensive use of antibiotics in a high-risk setting. (C) 2008 Elsevier B. V. and the International Society of Chemotherapy. All rights reserved.
AB - Meticillin-resistant Staphylococcus aureus (MRSA) is a very significant agent of recalcitrant healthcare-associated infections. A major risk of acquiring such infections is thought to be modulated by the use of particular antimicrobial therapies. The aim of this research was to evaluate prospectively the impact of using either ciprofloxacin or Tazocin (R) (piperacillin + tazobactam) on the incidence of MRSA in an Intensive Care Unit (ICU). The 1-year (2 x 6 months) cross-over study was carried out in a medium-sized (426 beds) teaching hospital. During the first 6-month period, ciprofloxacin was used as the first-line broad-spectrum antibiotic therapy of choice. During the second 6-month period, Tazocin (R) was used as first-line therapy. The incidence of hospital-acquired MRSA (i.e. colonised and/or infected) and rates of compliance of the ICU healthcare workers to optimal hand hygiene practices were recorded throughout the study. The study observed no statistically significant differences (P = 0.1) between MRSA incidence rates in the ICU during the ciprofloxacin (4.4/1000 bed-days) or Tazocin (R) (11.4/1000 bed- days) arms of the study. Interestingly, observing healthcare workers' hand hygiene practices throughout the entire study showed that healthcare workers adhered to these practices 59.2% of the time during the ciprofloxacin arm and 66.0% during the Tazocin (R) arm. The low incidence rates within the unit demonstrated the importance of infection control in limiting the spread of MRSA despite the extensive use of antibiotics in a high-risk setting. (C) 2008 Elsevier B. V. and the International Society of Chemotherapy. All rights reserved.
KW - Hospital-acquired MRSA
KW - Antibiotic resistance
KW - Infection control practices
U2 - 10.1016/j.ijantimicag.2008.06.021
DO - 10.1016/j.ijantimicag.2008.06.021
M3 - Article
VL - 32
SP - 499
EP - 504
JO - International Journal of Antimicrobial Agents
T2 - International Journal of Antimicrobial Agents
JF - International Journal of Antimicrobial Agents
SN - 0924-8579
IS - 6
ER -