Comparison of the effect of ciprofloxacin and Tazocin (R) on the incidence of meticillin-resistant Staphylococcus aureus (MRSA) in an Intensive Care Unit

Mamoon A. Aldeyab, Carmel M. Hughes, Mary P. Kearney, Michael G. Scott, DA McDowell, Joanne Hanley, MAS McMahon, Salah M. Elshibly, Ronald Bailie, James C. McElnay

    Research output: Contribution to journal › Article

    2 Citations (Scopus)

    Abstract

    Meticillin-resistant Staphylococcus aureus (MRSA) is a very significant agent of recalcitrant healthcare-associated infections. A major risk of acquiring such infections is thought to be modulated by the use of particular antimicrobial therapies. The aim of this research was to evaluate prospectively the impact of using either ciprofloxacin or Tazocin (R) (piperacillin + tazobactam) on the incidence of MRSA in an Intensive Care Unit (ICU). The 1-year (2 x 6 months) cross-over study was carried out in a medium-sized (426 beds) teaching hospital. During the first 6-month period, ciprofloxacin was used as the first-line broad-spectrum antibiotic therapy of choice. During the second 6-month period, Tazocin (R) was used as first-line therapy. The incidence of hospital-acquired MRSA (i.e. colonised and/or infected) and rates of compliance of the ICU healthcare workers to optimal hand hygiene practices were recorded throughout the study. The study observed no statistically significant differences (P = 0.1) between MRSA incidence rates in the ICU during the ciprofloxacin (4.4/1000 bed-days) or Tazocin (R) (11.4/1000 bed- days) arms of the study. Interestingly, observing healthcare workers' hand hygiene practices throughout the entire study showed that healthcare workers adhered to these practices 59.2% of the time during the ciprofloxacin arm and 66.0% during the Tazocin (R) arm. The low incidence rates within the unit demonstrated the importance of infection control in limiting the spread of MRSA despite the extensive use of antibiotics in a high-risk setting. (C) 2008 Elsevier B. V. and the International Society of Chemotherapy. All rights reserved.
    LanguageEnglish
    Pages499-504
    JournalInternational Journal of Antimicrobial Agents
    Volume32
    Issue number6
    DOIs
    Publication statusPublished - Dec 2008

    Fingerprint

    Methicillin
    Ciprofloxacin
    Intensive Care Units
    Staphylococcus aureus
    Incidence
    Hand Hygiene
    Delivery of Health Care
    Anti-Bacterial Agents
    Infection Control
    Cross Infection
    Teaching Hospitals
    Cross-Over Studies
    Therapeutics
    tazobactam drug combination piperacillin
    Drug Therapy
    Infection
    Research

    Keywords

    • Hospital-acquired MRSA
    • Antibiotic resistance
    • Infection control practices

    Cite this

    Aldeyab, M. A., Hughes, C. M., Kearney, M. P., Scott, M. G., McDowell, DA., Hanley, J., ... McElnay, J. C. (2008). Comparison of the effect of ciprofloxacin and Tazocin (R) on the incidence of meticillin-resistant Staphylococcus aureus (MRSA) in an Intensive Care Unit. 32(6), 499-504. https://doi.org/10.1016/j.ijantimicag.2008.06.021
    Aldeyab, Mamoon A. ; Hughes, Carmel M. ; Kearney, Mary P. ; Scott, Michael G. ; McDowell, DA ; Hanley, Joanne ; McMahon, MAS ; Elshibly, Salah M. ; Bailie, Ronald ; McElnay, James C. / Comparison of the effect of ciprofloxacin and Tazocin (R) on the incidence of meticillin-resistant Staphylococcus aureus (MRSA) in an Intensive Care Unit. 2008 ; Vol. 32, No. 6. pp. 499-504.
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    abstract = "Meticillin-resistant Staphylococcus aureus (MRSA) is a very significant agent of recalcitrant healthcare-associated infections. A major risk of acquiring such infections is thought to be modulated by the use of particular antimicrobial therapies. The aim of this research was to evaluate prospectively the impact of using either ciprofloxacin or Tazocin (R) (piperacillin + tazobactam) on the incidence of MRSA in an Intensive Care Unit (ICU). The 1-year (2 x 6 months) cross-over study was carried out in a medium-sized (426 beds) teaching hospital. During the first 6-month period, ciprofloxacin was used as the first-line broad-spectrum antibiotic therapy of choice. During the second 6-month period, Tazocin (R) was used as first-line therapy. The incidence of hospital-acquired MRSA (i.e. colonised and/or infected) and rates of compliance of the ICU healthcare workers to optimal hand hygiene practices were recorded throughout the study. The study observed no statistically significant differences (P = 0.1) between MRSA incidence rates in the ICU during the ciprofloxacin (4.4/1000 bed-days) or Tazocin (R) (11.4/1000 bed- days) arms of the study. Interestingly, observing healthcare workers' hand hygiene practices throughout the entire study showed that healthcare workers adhered to these practices 59.2{\%} of the time during the ciprofloxacin arm and 66.0{\%} during the Tazocin (R) arm. The low incidence rates within the unit demonstrated the importance of infection control in limiting the spread of MRSA despite the extensive use of antibiotics in a high-risk setting. (C) 2008 Elsevier B. V. and the International Society of Chemotherapy. All rights reserved.",
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    Aldeyab, MA, Hughes, CM, Kearney, MP, Scott, MG, McDowell, DA, Hanley, J, McMahon, MAS, Elshibly, SM, Bailie, R & McElnay, JC 2008, 'Comparison of the effect of ciprofloxacin and Tazocin (R) on the incidence of meticillin-resistant Staphylococcus aureus (MRSA) in an Intensive Care Unit', vol. 32, no. 6, pp. 499-504. https://doi.org/10.1016/j.ijantimicag.2008.06.021

    Comparison of the effect of ciprofloxacin and Tazocin (R) on the incidence of meticillin-resistant Staphylococcus aureus (MRSA) in an Intensive Care Unit. / Aldeyab, Mamoon A.; Hughes, Carmel M.; Kearney, Mary P.; Scott, Michael G.; McDowell, DA; Hanley, Joanne; McMahon, MAS; Elshibly, Salah M.; Bailie, Ronald; McElnay, James C.

    Vol. 32, No. 6, 12.2008, p. 499-504.

    Research output: Contribution to journal › Article

    TY - JOUR

    T1 - Comparison of the effect of ciprofloxacin and Tazocin (R) on the incidence of meticillin-resistant Staphylococcus aureus (MRSA) in an Intensive Care Unit

    AU - Aldeyab, Mamoon A.

    AU - Hughes, Carmel M.

    AU - Kearney, Mary P.

    AU - Scott, Michael G.

    AU - McDowell, DA

    AU - Hanley, Joanne

    AU - McMahon, MAS

    AU - Elshibly, Salah M.

    AU - Bailie, Ronald

    AU - McElnay, James C.

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    N2 - Meticillin-resistant Staphylococcus aureus (MRSA) is a very significant agent of recalcitrant healthcare-associated infections. A major risk of acquiring such infections is thought to be modulated by the use of particular antimicrobial therapies. The aim of this research was to evaluate prospectively the impact of using either ciprofloxacin or Tazocin (R) (piperacillin + tazobactam) on the incidence of MRSA in an Intensive Care Unit (ICU). The 1-year (2 x 6 months) cross-over study was carried out in a medium-sized (426 beds) teaching hospital. During the first 6-month period, ciprofloxacin was used as the first-line broad-spectrum antibiotic therapy of choice. During the second 6-month period, Tazocin (R) was used as first-line therapy. The incidence of hospital-acquired MRSA (i.e. colonised and/or infected) and rates of compliance of the ICU healthcare workers to optimal hand hygiene practices were recorded throughout the study. The study observed no statistically significant differences (P = 0.1) between MRSA incidence rates in the ICU during the ciprofloxacin (4.4/1000 bed-days) or Tazocin (R) (11.4/1000 bed- days) arms of the study. Interestingly, observing healthcare workers' hand hygiene practices throughout the entire study showed that healthcare workers adhered to these practices 59.2% of the time during the ciprofloxacin arm and 66.0% during the Tazocin (R) arm. The low incidence rates within the unit demonstrated the importance of infection control in limiting the spread of MRSA despite the extensive use of antibiotics in a high-risk setting. (C) 2008 Elsevier B. V. and the International Society of Chemotherapy. All rights reserved.

    AB - Meticillin-resistant Staphylococcus aureus (MRSA) is a very significant agent of recalcitrant healthcare-associated infections. A major risk of acquiring such infections is thought to be modulated by the use of particular antimicrobial therapies. The aim of this research was to evaluate prospectively the impact of using either ciprofloxacin or Tazocin (R) (piperacillin + tazobactam) on the incidence of MRSA in an Intensive Care Unit (ICU). The 1-year (2 x 6 months) cross-over study was carried out in a medium-sized (426 beds) teaching hospital. During the first 6-month period, ciprofloxacin was used as the first-line broad-spectrum antibiotic therapy of choice. During the second 6-month period, Tazocin (R) was used as first-line therapy. The incidence of hospital-acquired MRSA (i.e. colonised and/or infected) and rates of compliance of the ICU healthcare workers to optimal hand hygiene practices were recorded throughout the study. The study observed no statistically significant differences (P = 0.1) between MRSA incidence rates in the ICU during the ciprofloxacin (4.4/1000 bed-days) or Tazocin (R) (11.4/1000 bed- days) arms of the study. Interestingly, observing healthcare workers' hand hygiene practices throughout the entire study showed that healthcare workers adhered to these practices 59.2% of the time during the ciprofloxacin arm and 66.0% during the Tazocin (R) arm. The low incidence rates within the unit demonstrated the importance of infection control in limiting the spread of MRSA despite the extensive use of antibiotics in a high-risk setting. (C) 2008 Elsevier B. V. and the International Society of Chemotherapy. All rights reserved.

    KW - Hospital-acquired MRSA

    KW - Antibiotic resistance

    KW - Infection control practices

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    DO - 10.1016/j.ijantimicag.2008.06.021

    M3 - Article

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    Aldeyab MA, Hughes CM, Kearney MP, Scott MG, McDowell DA, Hanley J et al. Comparison of the effect of ciprofloxacin and Tazocin (R) on the incidence of meticillin-resistant Staphylococcus aureus (MRSA) in an Intensive Care Unit. 2008 Dec;32(6):499-504. https://doi.org/10.1016/j.ijantimicag.2008.06.021

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