Comparative vascular responses in elasmobranchs to different structures of neuropeptide Y and peptide YY

Elaine Preston; Ann Cathrine Jönsson; Clare D. McManus; J. Micheal Conlon; Gillian P. Courtice

doi:10.1016/S0167-0115(98)00116-5

Comparative vascular responses in elasmobranchs to different structures of neuropeptide Y and peptide YY

Elaine Preston
, Ann Cathrine Jönsson
, Clare D. McManus
, J. Micheal Conlon
, Gillian P. Courtice

School of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

The vascular responses to neuropeptide Y (NPY) and peptide YY (PYY) were tested in several species of elasmobranchs to assess whether changes in sequence in these neuropeptides from elasmobranchs to mammals are associated with different physiological responses. NPY-like immunoreactivity was detected in the gut and in nerve fibres surrounding some, but not all, blood vessels of six species. Intravenous injection of dogfish, frog and human NPY in anaesthetised fish caused similar vasopressor effects in the three species tested, except human NPY which lowered blood pressure in one of the three. Dogfish NPY and PYY were equipotent pressor agents in two species, but PYY was significantly more potent than NPY in one species. NPY and PYY both contracted isolated gut arteries from three species, but had no effect on isolated efferent arteries tested. In conclusion, differential vascular responses in elasmobranchs are not associated with changes in NPY sequence across vertebrates, but may be with changes in PYY in some species. Copyright (C) 1998 Elsevier Science B.V.

Original language	English
Pages (from-to)	57-67
Number of pages	11
Journal	Regulatory Peptides
Volume	78
Issue number	1-3
DOIs	https://doi.org/10.1016/S0167-0115(98)00116-5
Publication status	Published (in print/issue) - 30 Nov 1998

Funding

This study was supported by the Australian Research Council. We are grateful to New South Wales State Fisheries Department for collection of Port Jackson sharks, and to the Sydney Aquarium, Darling Harbour for maintenance of the sharks prior to experimentation. We would like to thank the director and staff of the Heron Island Research Station for allowing us to use their facilities, and Dr. M. Bennett, Dr. S. Bennett, Dr. L.C. Llewellyn and John and Lisa Chopin for their assistance in capture of the animals and in the laboratory at Heron Island. We would also like to thank Parvin Korchki for expert technical assistance with the immunohistochemistry.

Funders
Australian Research Council

Keywords

Blood pressure
Immunohistochemistry
Isolated vessels
NPY
PYY
Vasoconstriction

Access to Document

10.1016/S0167-0115(98)00116-5

Cite this

@article{42e5420bb3e14bef8dea4c197958d872,

title = "Comparative vascular responses in elasmobranchs to different structures of neuropeptide Y and peptide YY",

abstract = "The vascular responses to neuropeptide Y (NPY) and peptide YY (PYY) were tested in several species of elasmobranchs to assess whether changes in sequence in these neuropeptides from elasmobranchs to mammals are associated with different physiological responses. NPY-like immunoreactivity was detected in the gut and in nerve fibres surrounding some, but not all, blood vessels of six species. Intravenous injection of dogfish, frog and human NPY in anaesthetised fish caused similar vasopressor effects in the three species tested, except human NPY which lowered blood pressure in one of the three. Dogfish NPY and PYY were equipotent pressor agents in two species, but PYY was significantly more potent than NPY in one species. NPY and PYY both contracted isolated gut arteries from three species, but had no effect on isolated efferent arteries tested. In conclusion, differential vascular responses in elasmobranchs are not associated with changes in NPY sequence across vertebrates, but may be with changes in PYY in some species. Copyright (C) 1998 Elsevier Science B.V.",

keywords = "Blood pressure, Immunohistochemistry, Isolated vessels, NPY, PYY, Vasoconstriction",

author = "Elaine Preston and J{\"o}nsson, \{Ann Cathrine\} and McManus, \{Clare D.\} and Conlon, \{J. Micheal\} and Courtice, \{Gillian P.\}",

year = "1998",

month = nov,

day = "30",

doi = "10.1016/S0167-0115(98)00116-5",

language = "English",

volume = "78",

pages = "57--67",

journal = "Regulatory Peptides",

issn = "0167-0115",

publisher = "Elsevier",

number = "1-3",

}

TY - JOUR

T1 - Comparative vascular responses in elasmobranchs to different structures of neuropeptide Y and peptide YY

AU - Preston, Elaine

AU - Jönsson, Ann Cathrine

AU - McManus, Clare D.

AU - Conlon, J. Micheal

AU - Courtice, Gillian P.

PY - 1998/11/30

Y1 - 1998/11/30

N2 - The vascular responses to neuropeptide Y (NPY) and peptide YY (PYY) were tested in several species of elasmobranchs to assess whether changes in sequence in these neuropeptides from elasmobranchs to mammals are associated with different physiological responses. NPY-like immunoreactivity was detected in the gut and in nerve fibres surrounding some, but not all, blood vessels of six species. Intravenous injection of dogfish, frog and human NPY in anaesthetised fish caused similar vasopressor effects in the three species tested, except human NPY which lowered blood pressure in one of the three. Dogfish NPY and PYY were equipotent pressor agents in two species, but PYY was significantly more potent than NPY in one species. NPY and PYY both contracted isolated gut arteries from three species, but had no effect on isolated efferent arteries tested. In conclusion, differential vascular responses in elasmobranchs are not associated with changes in NPY sequence across vertebrates, but may be with changes in PYY in some species. Copyright (C) 1998 Elsevier Science B.V.

AB - The vascular responses to neuropeptide Y (NPY) and peptide YY (PYY) were tested in several species of elasmobranchs to assess whether changes in sequence in these neuropeptides from elasmobranchs to mammals are associated with different physiological responses. NPY-like immunoreactivity was detected in the gut and in nerve fibres surrounding some, but not all, blood vessels of six species. Intravenous injection of dogfish, frog and human NPY in anaesthetised fish caused similar vasopressor effects in the three species tested, except human NPY which lowered blood pressure in one of the three. Dogfish NPY and PYY were equipotent pressor agents in two species, but PYY was significantly more potent than NPY in one species. NPY and PYY both contracted isolated gut arteries from three species, but had no effect on isolated efferent arteries tested. In conclusion, differential vascular responses in elasmobranchs are not associated with changes in NPY sequence across vertebrates, but may be with changes in PYY in some species. Copyright (C) 1998 Elsevier Science B.V.

KW - Blood pressure

KW - Immunohistochemistry

KW - Isolated vessels

KW - NPY

KW - PYY

KW - Vasoconstriction

UR - https://www.scopus.com/pages/publications/0032583198

U2 - 10.1016/S0167-0115(98)00116-5

DO - 10.1016/S0167-0115(98)00116-5

M3 - Article

C2 - 9879747

AN - SCOPUS:0032583198

SN - 0167-0115

VL - 78

SP - 57

EP - 67

JO - Regulatory Peptides

JF - Regulatory Peptides

IS - 1-3

ER -

Comparative vascular responses in elasmobranchs to different structures of neuropeptide Y and peptide YY

Abstract

Funding

Keywords

Access to Document

Other files and links

Fingerprint

Cite this