Comparative study of surface properties of Mg-substituted hydroxyapatitebioceramic microspheres

Liga Stipniece, Valentina Stepanova, Inga Narkevica, Kristine Salma-Ancane, Adrian Boyd

Research output: Contribution to journal › Article

3 Citations (Scopus)

Abstract

Mg-substituted hydroxyapatite (HAp) bioceramic microspheres were prepared by spray drying and subsequent processing at 1173, 1273 and 1373 K. Influence of various Mg substitution levels (up to 0.84 ± 0.10 wt%) on physicochemical properties of the HAp bioceramic microspheres was evaluated. Obtained results were used for the elucidation of the compositional and structural characteristics of the microspheres in conjunction with adsorption of protein, namely, bovine serum albumin (BSA). The primary difference among the microspheres processed at various temperature was the presence or absence of the micropores (<2 nm in diameter) and mesopores (between 2 and 50 nm). Presence of the micro- and mesopores resulted in higher specific surface area (SSA), enhanced solubility, i.e., ion release, and, accordingly, increase in the amount of BSA adsorbed on the microspheres. Furthermore, the BSA adsorption capacity of the microspheres decreased with increasing Mg content despite of higher SSA.
LanguageEnglish
Pages761-768
JournalJournal of the European Ceramic Society
Volume38
Issue number2
Early online date19 Sep 2017
DOIs
Publication statusPublished - Feb 2018

Fingerprint

Microspheres
Surface properties
Bovine Serum Albumin
Bioceramics
Durapatite
Hydroxyapatite
Specific surface area
Adsorption
Spray drying
Substitution reactions
Solubility
Ions
Proteins
Processing
Temperature

Keywords

  • Hydroxyapatite
  • Bioceramic
  • Microspheres
  • Mg substitution
  • Protein adsorption

Cite this

Stipniece, Liga ; Stepanova, Valentina ; Narkevica, Inga ; Salma-Ancane, Kristine ; Boyd, Adrian. / Comparative study of surface properties of Mg-substituted hydroxyapatitebioceramic microspheres. In: Journal of the European Ceramic Society. 2018 ; Vol. 38, No. 2. pp. 761-768.
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abstract = "Mg-substituted hydroxyapatite (HAp) bioceramic microspheres were prepared by spray drying and subsequent processing at 1173, 1273 and 1373 K. Influence of various Mg substitution levels (up to 0.84 ± 0.10 wt{\%}) on physicochemical properties of the HAp bioceramic microspheres was evaluated. Obtained results were used for the elucidation of the compositional and structural characteristics of the microspheres in conjunction with adsorption of protein, namely, bovine serum albumin (BSA). The primary difference among the microspheres processed at various temperature was the presence or absence of the micropores (<2 nm in diameter) and mesopores (between 2 and 50 nm). Presence of the micro- and mesopores resulted in higher specific surface area (SSA), enhanced solubility, i.e., ion release, and, accordingly, increase in the amount of BSA adsorbed on the microspheres. Furthermore, the BSA adsorption capacity of the microspheres decreased with increasing Mg content despite of higher SSA.",
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Stipniece, L, Stepanova, V, Narkevica, I, Salma-Ancane, K & Boyd, A 2018, 'Comparative study of surface properties of Mg-substituted hydroxyapatitebioceramic microspheres', Journal of the European Ceramic Society, vol. 38, no. 2, pp. 761-768. https://doi.org/10.1016/j.jeurceramsoc.2017.09.026

Comparative study of surface properties of Mg-substituted hydroxyapatitebioceramic microspheres. / Stipniece, Liga; Stepanova, Valentina; Narkevica, Inga; Salma-Ancane, Kristine; Boyd, Adrian.

In: Journal of the European Ceramic Society, Vol. 38, No. 2, 02.2018, p. 761-768.

Research output: Contribution to journal › Article

TY - JOUR

T1 - Comparative study of surface properties of Mg-substituted hydroxyapatitebioceramic microspheres

AU - Stipniece, Liga

AU - Stepanova, Valentina

AU - Narkevica, Inga

AU - Salma-Ancane, Kristine

AU - Boyd, Adrian

N1 - Compliant in UIR; evidence uploaded to 'Other files'

PY - 2018/2

Y1 - 2018/2

N2 - Mg-substituted hydroxyapatite (HAp) bioceramic microspheres were prepared by spray drying and subsequent processing at 1173, 1273 and 1373 K. Influence of various Mg substitution levels (up to 0.84 ± 0.10 wt%) on physicochemical properties of the HAp bioceramic microspheres was evaluated. Obtained results were used for the elucidation of the compositional and structural characteristics of the microspheres in conjunction with adsorption of protein, namely, bovine serum albumin (BSA). The primary difference among the microspheres processed at various temperature was the presence or absence of the micropores (<2 nm in diameter) and mesopores (between 2 and 50 nm). Presence of the micro- and mesopores resulted in higher specific surface area (SSA), enhanced solubility, i.e., ion release, and, accordingly, increase in the amount of BSA adsorbed on the microspheres. Furthermore, the BSA adsorption capacity of the microspheres decreased with increasing Mg content despite of higher SSA.

AB - Mg-substituted hydroxyapatite (HAp) bioceramic microspheres were prepared by spray drying and subsequent processing at 1173, 1273 and 1373 K. Influence of various Mg substitution levels (up to 0.84 ± 0.10 wt%) on physicochemical properties of the HAp bioceramic microspheres was evaluated. Obtained results were used for the elucidation of the compositional and structural characteristics of the microspheres in conjunction with adsorption of protein, namely, bovine serum albumin (BSA). The primary difference among the microspheres processed at various temperature was the presence or absence of the micropores (<2 nm in diameter) and mesopores (between 2 and 50 nm). Presence of the micro- and mesopores resulted in higher specific surface area (SSA), enhanced solubility, i.e., ion release, and, accordingly, increase in the amount of BSA adsorbed on the microspheres. Furthermore, the BSA adsorption capacity of the microspheres decreased with increasing Mg content despite of higher SSA.

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KW - Bioceramic

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Stipniece L, Stepanova V, Narkevica I, Salma-Ancane K, Boyd A. Comparative study of surface properties of Mg-substituted hydroxyapatitebioceramic microspheres. Journal of the European Ceramic Society. 2018 Feb;38(2):761-768. https://doi.org/10.1016/j.jeurceramsoc.2017.09.026

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