Comparative Studies on Conventional and Microwave Assisted Synthesis of Novel Quinoxalinone Derivatives as Antimicrobial Agents

Sweta Sahu, B.P. Nagori, Vaibhav Dubey, Alok Semwal

Research output: Contribution to journalArticlepeer-review

Abstract

A facile green protocol has been developed for the synthesis of a series of 3-methylquinoxalin-2 (1H) -one substituted 1,2,4-triazole derivatives under microwave irradiation. Besides, these compounds were also synthesized by conventional heating procedures for comparison. In a relative study, microwave-assisted synthesis lead to higher yields of target compound within very short reaction time than conventional counterparts. The structures of these derivatives were ascertained through FTIR, Mass, NMR and elemental analysis. These
target analogues were also found to exhibit considerable inhibitory activity against disease causing microorganisms.
Original languageEnglish
Pages (from-to)296-304
Number of pages9
JournalInternational journal of Pharmaceutical and medicinal research
Volume4
Issue number1
Early online date29 Feb 2016
Publication statusE-pub ahead of print - 29 Feb 2016

Keywords

  • 3-methyl-quinoxalin-2(1H)-one
  • Carbothioamide
  • Microwave irradiation
  • Antimicrobial activity
  • Triazole

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