Comparative Studies on Conventional and Microwave Assisted Synthesis of Novel Quinoxalinone Derivatives as Antimicrobial Agents

Sweta Sahu; B.P. Nagori; Vaibhav Dubey; Alok Semwal

Comparative Studies on Conventional and Microwave Assisted Synthesis of Novel Quinoxalinone Derivatives as Antimicrobial Agents

Sweta Sahu, B.P. Nagori, Vaibhav Dubey, Alok Semwal

School of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

A facile green protocol has been developed for the synthesis of a series of 3-methylquinoxalin-2 (1H) -one substituted 1,2,4-triazole derivatives under microwave irradiation. Besides, these compounds were also synthesized by conventional heating procedures for comparison. In a relative study, microwave-assisted synthesis lead to higher yields of target compound within very short reaction time than conventional counterparts. The structures of these derivatives were ascertained through FTIR, Mass, NMR and elemental analysis. These
target analogues were also found to exhibit considerable inhibitory activity against disease causing microorganisms.

Original language	English
Pages (from-to)	296-304
Number of pages	9
Journal	International journal of Pharmaceutical and medicinal research
Volume	4
Issue number	1
Early online date	29 Feb 2016
Publication status	Published online - 29 Feb 2016

Keywords

3-methyl-quinoxalin-2(1H)-one
Carbothioamide
Microwave irradiation
Antimicrobial activity
Triazole

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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AU - Semwal, Alok

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AB - A facile green protocol has been developed for the synthesis of a series of 3-methylquinoxalin-2 (1H) -one substituted 1,2,4-triazole derivatives under microwave irradiation. Besides, these compounds were also synthesized by conventional heating procedures for comparison. In a relative study, microwave-assisted synthesis lead to higher yields of target compound within very short reaction time than conventional counterparts. The structures of these derivatives were ascertained through FTIR, Mass, NMR and elemental analysis. Thesetarget analogues were also found to exhibit considerable inhibitory activity against disease causing microorganisms.

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KW - Carbothioamide

KW - Microwave irradiation

KW - Antimicrobial activity

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IS - 1

ER -

Comparative Studies on Conventional and Microwave Assisted Synthesis of Novel Quinoxalinone Derivatives as Antimicrobial Agents

Abstract

Keywords

UN SDGs

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