Comparative bioactivity studies on two Mimosa species

Samuel Genest, Conor Kerr, Ankit Shah, M. Mukhlesur Rahman, Gadria M. M. Saif-E-Naser, Poonam Singh - Nee Nigam, Lutfun Nahar, Satyajit D. Sarker

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Abstract

Comparative antioxidant, antibacterial activities and general toxicity studies on the n-hexane, dichloromethane (DCM) and methanol (MeOH) extracts of Mimosa pudica and Mimosa rubicaulis, two Bangladeshi medicinal plants, were carried out, using the 2,2-diphenyl-1-picryl-hydrazyl (DPPH) assay, the resazurin microtitre plate based assay, and the brine shrimp lethality assay, respectively. The DCM and MeOH extracts of both M. pudica and M. rubicaulis showed prominent antioxidant property, with the RC50 values ranging from 4.70 x 10(-1) to 2.10 x 10(-2) mg/mL. While M. rubicaulis did not show any antibacterial activity, the DCM and the MeOH extracts of M. pudica displayed considerable bacteriostatic activity against all six bacterial strains (MIC range = 0.625-2.50 mg/mL) including Bacillus cereus, B. subtilis, Escherichia coli, ampicillin-resistant Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa. None of these plants exhibited any significant toxicity towards brine shrimps.
LanguageEnglish
Pages38-43
JournalBoletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas
Volume7
Issue number1
Publication statusPublished - 2008

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Mimosa
Methylene Chloride
Artemia
Antioxidants
Escherichia coli
Bacillus cereus
Ampicillin
Medicinal Plants
Pseudomonas aeruginosa
Methanol
Staphylococcus aureus

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Genest, S., Kerr, C., Shah, A., Rahman, M. M., Saif-E-Naser, G. M. M., Singh - Nee Nigam, P., ... Sarker, S. D. (2008). Comparative bioactivity studies on two Mimosa species. 7(1), 38-43.
Genest, Samuel ; Kerr, Conor ; Shah, Ankit ; Rahman, M. Mukhlesur ; Saif-E-Naser, Gadria M. M. ; Singh - Nee Nigam, Poonam ; Nahar, Lutfun ; Sarker, Satyajit D. / Comparative bioactivity studies on two Mimosa species. 2008 ; Vol. 7, No. 1. pp. 38-43.
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Genest, S, Kerr, C, Shah, A, Rahman, MM, Saif-E-Naser, GMM, Singh - Nee Nigam, P, Nahar, L & Sarker, SD 2008, 'Comparative bioactivity studies on two Mimosa species', vol. 7, no. 1, pp. 38-43.

Comparative bioactivity studies on two Mimosa species. / Genest, Samuel; Kerr, Conor; Shah, Ankit; Rahman, M. Mukhlesur; Saif-E-Naser, Gadria M. M.; Singh - Nee Nigam, Poonam; Nahar, Lutfun; Sarker, Satyajit D.

Vol. 7, No. 1, 2008, p. 38-43.

Research output: Contribution to journalArticle

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AU - Genest, Samuel

AU - Kerr, Conor

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AU - Rahman, M. Mukhlesur

AU - Saif-E-Naser, Gadria M. M.

AU - Singh - Nee Nigam, Poonam

AU - Nahar, Lutfun

AU - Sarker, Satyajit D.

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AB - Comparative antioxidant, antibacterial activities and general toxicity studies on the n-hexane, dichloromethane (DCM) and methanol (MeOH) extracts of Mimosa pudica and Mimosa rubicaulis, two Bangladeshi medicinal plants, were carried out, using the 2,2-diphenyl-1-picryl-hydrazyl (DPPH) assay, the resazurin microtitre plate based assay, and the brine shrimp lethality assay, respectively. The DCM and MeOH extracts of both M. pudica and M. rubicaulis showed prominent antioxidant property, with the RC50 values ranging from 4.70 x 10(-1) to 2.10 x 10(-2) mg/mL. While M. rubicaulis did not show any antibacterial activity, the DCM and the MeOH extracts of M. pudica displayed considerable bacteriostatic activity against all six bacterial strains (MIC range = 0.625-2.50 mg/mL) including Bacillus cereus, B. subtilis, Escherichia coli, ampicillin-resistant Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa. None of these plants exhibited any significant toxicity towards brine shrimps.

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Genest S, Kerr C, Shah A, Rahman MM, Saif-E-Naser GMM, Singh - Nee Nigam P et al. Comparative bioactivity studies on two Mimosa species. 2008;7(1):38-43.