Comparative analysis of synovial fluid and plasma proteomes in juvenile arthritis – Proteomic patterns of joint inflammation in early stage disease

David Gibson, Sarah Blelock, Jim Curry, Sorcha Finnegan, Adrienne Healy, Caitriona Scaife, Catherine McAllister, Stephen Pennington, Michael Dunn, Madeleine Rooney

    Research output: Contribution to journalArticle

    22 Citations (Scopus)

    Abstract

    Synovial fluid is a potential source of novel biomarkers for many arthritic disordersinvolving joint inflammation, including juvenile idiopathic arthritis. We first compared thedistinctive protein ‘fingerprints’ of local inflammation in synovial fluid with systemicprofiles within matched plasma samples. The synovial fluid proteome at the time of jointinflammation was then evaluated across clinical subgroups to identify early diseaseassociated proteins. We measured the synovial fluid and plasma proteomes using the two dimensional fluorescence difference gel electrophoresis approach. Image analysis software was used to highlight the expression levels of joint and subgroup associated proteins acrossthe study cohort (n=32). A defined subset of 30 proteins had statistically significantdifferences (p
    Original languageEnglish
    Pages (from-to)656-876
    JournalJournal of Proteomics
    Volume72
    Publication statusPublished - 6 Jan 2009

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