Common transcription factors between Hepatitis B virus (HBV) and Interleukin-8 (IL-8)

The immune system is connected by many signalling proteins known as cytokines and chemokines. These proteins are encoded by genes of the immune system which can be activated by many stimuli such as viral infection. It is therefore conceivable that control of gene regulation in both host and virus, may employ common mechanisms. Here we look at Interleukin-8 (IL-8) and Hepatitis B virus (HBV). The transcription factors that bind to the selected promoters and enhancers were identified from an extensive literature base. The data provided by the literature regarding each promoter or enhancer was recorded in a database. This data was then assembled to produce a map for both a host gene promoter and a viral promoter or enhancer region using the Systems Biology Genomic Notation (SBGN). These maps define how theses factors interact and the position at which this interaction occurs within the region of interest.