Common pathological processes in Alzheimer disease and type 2 diabetes: a review.

Lin Li, Christian Holscher

    Research output: Contribution to journalArticle

    260 Citations (Scopus)

    Abstract

    Alzheimer disease (AD) and type 2 diabetes mellitus (T2DM) are conditions that affect a large number of people in the industrialized countries. Both conditions are on the increase, and finding novel treatments to cure or prevent them are a major aim in research. Somewhat surprisingly, AD and T2DM share several molecular processes that underlie the respective degenerative developments. This review describes and discusses several of these shared biochemical and physiological pathways. Disturbances in insulin signalling appears to be the main common impairment that affects cell growth and differentiation, cellular repair mechanisms, energy metabolism, and glucose utilization. Insulin not only regulates blood sugar levels but also acts as a growth factor on all cells including neurons in the CNS. Impairment of insulin signalling therefore not only affects blood glucose levels but also causes numerous degenerative processes. Other growth factor signalling systems such as insulin growth factors (IGFs) and transforming growth factors (TGFs) also are affected in both conditions. Also, the misfolding of proteins plays an important role in both diseases, as does the aggregation of amyloid peptides and of hyperphosphorylated proteins. Furthermore, more general physiological processes such as angiopathic and cytotoxic developments, the induction of apoptosis, or of non-apoptotic cell death via production of free radicals greatly influence the progression of AD and T2DM. The increase of detailed knowledge of these common physiological processes open up the opportunities for treatments that can prevent or reduce the onset of AD as well as T2DM.
    LanguageEnglish
    Pages384-402
    JournalBrain Research Reviews
    Volume56
    Issue number2
    Publication statusPublished - 2007

    Fingerprint

    Pathologic Processes
    Type 2 Diabetes Mellitus
    Insulin
    Physiological Phenomena
    Intercellular Signaling Peptides and Proteins
    Blood Glucose
    Transforming Growth Factors
    Developed Countries
    Amyloid
    Energy Metabolism
    Free Radicals
    Cell Differentiation
    Alzheimer Disease
    Proteins
    Cell Death
    Apoptosis
    Neurons
    Glucose
    Peptides
    Alzheimer disease type 2

    Cite this

    Li, Lin ; Holscher, Christian. / Common pathological processes in Alzheimer disease and type 2 diabetes: a review. In: Brain Research Reviews. 2007 ; Vol. 56, No. 2. pp. 384-402.
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    Common pathological processes in Alzheimer disease and type 2 diabetes: a review. / Li, Lin; Holscher, Christian.

    In: Brain Research Reviews, Vol. 56, No. 2, 2007, p. 384-402.

    Research output: Contribution to journalArticle

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    AB - Alzheimer disease (AD) and type 2 diabetes mellitus (T2DM) are conditions that affect a large number of people in the industrialized countries. Both conditions are on the increase, and finding novel treatments to cure or prevent them are a major aim in research. Somewhat surprisingly, AD and T2DM share several molecular processes that underlie the respective degenerative developments. This review describes and discusses several of these shared biochemical and physiological pathways. Disturbances in insulin signalling appears to be the main common impairment that affects cell growth and differentiation, cellular repair mechanisms, energy metabolism, and glucose utilization. Insulin not only regulates blood sugar levels but also acts as a growth factor on all cells including neurons in the CNS. Impairment of insulin signalling therefore not only affects blood glucose levels but also causes numerous degenerative processes. Other growth factor signalling systems such as insulin growth factors (IGFs) and transforming growth factors (TGFs) also are affected in both conditions. Also, the misfolding of proteins plays an important role in both diseases, as does the aggregation of amyloid peptides and of hyperphosphorylated proteins. Furthermore, more general physiological processes such as angiopathic and cytotoxic developments, the induction of apoptosis, or of non-apoptotic cell death via production of free radicals greatly influence the progression of AD and T2DM. The increase of detailed knowledge of these common physiological processes open up the opportunities for treatments that can prevent or reduce the onset of AD as well as T2DM.

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