Combinational effect of angiotensin receptor blocker and folic acid therapy on uric acid and creatinine level in hyperhomocysteinemia-associated hypertension

Yogendra Singh, Vijaya Paul Samuel, Sunita Dahiya, Gaurav Gupta, Ritu Gillhotra, Anurag Mishra, Mahaveer Singh, Nagaraja SreeHarsha, Shiva Kumar Gubbiyappa, Murtaza M. Tambuwala, Dinesh Kumar Chellappan, Kamal Dua

    Research output: Contribution to journalReview article

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    Abstract

    Homocysteine [HSCH2CH2CH(NH2)COOH] (Hcy) is a sulfur-containing amino acid of 135.18 Da of molecular weight, generated during conversion of methionine to cysteine. If there is a higher accumulation of Hcy in the blood, that is usually above 15 µmol/L, it leads to a condition referred to as hyperhomocysteinemia. A meta-analysis of observational study suggested an elevated concentration of Hcy in blood, which is termed as the risk factors leading to ischemic heart disease and stroke. Further experimental studies stated that Hcy can lead to an increase in the proliferation of vascular smooth muscle cells and functional impairment of endothelial cells. The analyses confirmed some of the predictors for Hcy presence, such as serum uric acid (UA), systolic blood pressure, and hematocrit. However, angiotensin-converting enzyme inhibitors angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) alone are inadequate for controlling UA and creatinine level, although the addition of folic acid may be beneficial in hypertensive patients who are known to have a high prevalence of elevated Hcy. We hypothesized that combination therapy with an ARB (olmesartan) and folic acid is a promising treatment for lowering the UA and creatinine level in hyperhomocysteinemia-associated hypertension.

    Original languageEnglish
    Pages (from-to)715-719
    Number of pages5
    JournalBiotechnology and Applied Biochemistry
    Volume66
    Issue number5
    Early online date17 Jul 2019
    DOIs
    Publication statusPublished - 1 Sep 2019

    Keywords

    • angiotensin receptor blocker
    • creatinine
    • folic acid
    • homocysteine
    • hyperhomocysteinemia
    • hypertension

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  • Cite this

    Singh, Y., Samuel, V. P., Dahiya, S., Gupta, G., Gillhotra, R., Mishra, A., Singh, M., SreeHarsha, N., Gubbiyappa, S. K., Tambuwala, M. M., Chellappan, D. K., & Dua, K. (2019). Combinational effect of angiotensin receptor blocker and folic acid therapy on uric acid and creatinine level in hyperhomocysteinemia-associated hypertension. Biotechnology and Applied Biochemistry, 66(5), 715-719. https://doi.org/10.1002/bab.1799