Colorectal cancer and the relationship between genes and the environment.

Patricia M Heavey, Declan J McKenna, Ian R Rowland

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Colorectal cancer (CRC) is a significant cause of morbidity and mortality in developed countries, with both genetic and environmental factors contributing to the etiology and progression of the disease. Several risk factors have been identified, including positive family history, red meat intake, smoking, and alcohol intake. Protective factors include vegetables, calcium, hormone replacement therapy, folate, nonsteroidal anti-inflammatory drugs, and physical activity. The interaction between these environmental factors, in particular diet and genes, is an area of growing interest. Currently, oncogenes, tumor suppressor genes, and mismatch repair genes are believed to play an essential role in colorectal carcinogenesis. When considering the genetics of CRC, only 10% of cases are inherited and only 2-6% can be ascribed to the highly penetrant genes, such as APC, hMLH and hMSH2. Lower penetrance genes combined with a Western-style diet contribute to the majority of sporadic CRCs. The purpose of this article is to give a brief overview of the epidemiologic studies that have been conducted and present the major findings. Here, we examine the molecular events in CRC, with particular focus on the interaction between genes and environment, and review the most current research in this area.
LanguageEnglish
Pages124-41
JournalNutrition and cancer
Volume48
Issue number2
Publication statusPublished - 2004

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Colorectal Neoplasms
Genes
Diet
Gene-Environment Interaction
DNA Mismatch Repair
Penetrance
Hormone Replacement Therapy
Tumor Suppressor Genes
Oncogenes
Folic Acid
Developed Countries
Vegetables
Disease Progression
Epidemiologic Studies
Carcinogenesis
Anti-Inflammatory Agents
Smoking
Alcohols
Calcium
Morbidity

Cite this

Heavey, Patricia M ; McKenna, Declan J ; Rowland, Ian R. / Colorectal cancer and the relationship between genes and the environment. In: Nutrition and cancer. 2004 ; Vol. 48, No. 2. pp. 124-41.
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abstract = "Colorectal cancer (CRC) is a significant cause of morbidity and mortality in developed countries, with both genetic and environmental factors contributing to the etiology and progression of the disease. Several risk factors have been identified, including positive family history, red meat intake, smoking, and alcohol intake. Protective factors include vegetables, calcium, hormone replacement therapy, folate, nonsteroidal anti-inflammatory drugs, and physical activity. The interaction between these environmental factors, in particular diet and genes, is an area of growing interest. Currently, oncogenes, tumor suppressor genes, and mismatch repair genes are believed to play an essential role in colorectal carcinogenesis. When considering the genetics of CRC, only 10{\%} of cases are inherited and only 2-6{\%} can be ascribed to the highly penetrant genes, such as APC, hMLH and hMSH2. Lower penetrance genes combined with a Western-style diet contribute to the majority of sporadic CRCs. The purpose of this article is to give a brief overview of the epidemiologic studies that have been conducted and present the major findings. Here, we examine the molecular events in CRC, with particular focus on the interaction between genes and environment, and review the most current research in this area.",
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Colorectal cancer and the relationship between genes and the environment. / Heavey, Patricia M; McKenna, Declan J; Rowland, Ian R.

In: Nutrition and cancer, Vol. 48, No. 2, 2004, p. 124-41.

Research output: Contribution to journalArticle

TY - JOUR

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AU - McKenna, Declan J

AU - Rowland, Ian R

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AB - Colorectal cancer (CRC) is a significant cause of morbidity and mortality in developed countries, with both genetic and environmental factors contributing to the etiology and progression of the disease. Several risk factors have been identified, including positive family history, red meat intake, smoking, and alcohol intake. Protective factors include vegetables, calcium, hormone replacement therapy, folate, nonsteroidal anti-inflammatory drugs, and physical activity. The interaction between these environmental factors, in particular diet and genes, is an area of growing interest. Currently, oncogenes, tumor suppressor genes, and mismatch repair genes are believed to play an essential role in colorectal carcinogenesis. When considering the genetics of CRC, only 10% of cases are inherited and only 2-6% can be ascribed to the highly penetrant genes, such as APC, hMLH and hMSH2. Lower penetrance genes combined with a Western-style diet contribute to the majority of sporadic CRCs. The purpose of this article is to give a brief overview of the epidemiologic studies that have been conducted and present the major findings. Here, we examine the molecular events in CRC, with particular focus on the interaction between genes and environment, and review the most current research in this area.

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