Color discrimination assessment in patients with hypothyroidism using the Farnsworth-Munsell 100 hue test.

Kalina Racheva, Tsvetalin Totev, Emil Natchev, Nadejda Bocheva, Raymond Beirne, Margarita Vidinova-Zlatkova

Research output: Contribution to journalArticle

Abstract

There is evidence in the literature that hypofunction of the thyroid gland (hypothyroidism) affects color vision in rodents by influencing the production of the visual pigment opsin. The effect of hypothyroidism on color vision in humans has not been examined in any great detail. In this cross-sectional study we evaluated color discrimination using the Farnsworth-Munsell 100 hue test (FM-100) in 25 individuals with pre-treatment hypothyroidism (mean age 38±9.2 Yrs), and a control euthyroid group, n=26 (mean age 39.6±8.4 Yrs). There was no statistically significant difference in the total error score (TES) between the groups, but the hypothyroid group had a significantly greater partial error scores (PES) along the blue-yellow (B-Y) axis compared to the red-green (R-G) axis. No statistically significant differences in B-Y and R-G PES were observed in the control group. This study shows that hypothyroidism affects color vision in humans, causing significant impairment in the B-Y color subsystem.
LanguageEnglish
JournalJournal of the Optical Society of America A
Publication statusAccepted/In press - 10 Jan 2020

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Color vision
color vision
discrimination
Color
color
Opsins
Retinal Pigments
visual pigments
thyroid gland
Pigments
rodents
impairment
pretreatment
frequency modulation

Keywords

  • Color vision
  • thyroid function

Cite this

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title = "Color discrimination assessment in patients with hypothyroidism using the Farnsworth-Munsell 100 hue test.",
abstract = "There is evidence in the literature that hypofunction of the thyroid gland (hypothyroidism) affects color vision in rodents by influencing the production of the visual pigment opsin. The effect of hypothyroidism on color vision in humans has not been examined in any great detail. In this cross-sectional study we evaluated color discrimination using the Farnsworth-Munsell 100 hue test (FM-100) in 25 individuals with pre-treatment hypothyroidism (mean age 38±9.2 Yrs), and a control euthyroid group, n=26 (mean age 39.6±8.4 Yrs). There was no statistically significant difference in the total error score (TES) between the groups, but the hypothyroid group had a significantly greater partial error scores (PES) along the blue-yellow (B-Y) axis compared to the red-green (R-G) axis. No statistically significant differences in B-Y and R-G PES were observed in the control group. This study shows that hypothyroidism affects color vision in humans, causing significant impairment in the B-Y color subsystem.",
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author = "Kalina Racheva and Tsvetalin Totev and Emil Natchev and Nadejda Bocheva and Raymond Beirne and Margarita Vidinova-Zlatkova",
year = "2020",
month = "1",
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language = "English",
journal = "Journal of the Optical Society of America A",
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Color discrimination assessment in patients with hypothyroidism using the Farnsworth-Munsell 100 hue test. / Racheva, Kalina; Totev, Tsvetalin; Natchev, Emil; Bocheva, Nadejda; Beirne, Raymond; Vidinova-Zlatkova, Margarita.

In: Journal of the Optical Society of America A, 10.01.2020.

Research output: Contribution to journalArticle

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T1 - Color discrimination assessment in patients with hypothyroidism using the Farnsworth-Munsell 100 hue test.

AU - Racheva, Kalina

AU - Totev, Tsvetalin

AU - Natchev, Emil

AU - Bocheva, Nadejda

AU - Beirne, Raymond

AU - Vidinova-Zlatkova, Margarita

PY - 2020/1/10

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N2 - There is evidence in the literature that hypofunction of the thyroid gland (hypothyroidism) affects color vision in rodents by influencing the production of the visual pigment opsin. The effect of hypothyroidism on color vision in humans has not been examined in any great detail. In this cross-sectional study we evaluated color discrimination using the Farnsworth-Munsell 100 hue test (FM-100) in 25 individuals with pre-treatment hypothyroidism (mean age 38±9.2 Yrs), and a control euthyroid group, n=26 (mean age 39.6±8.4 Yrs). There was no statistically significant difference in the total error score (TES) between the groups, but the hypothyroid group had a significantly greater partial error scores (PES) along the blue-yellow (B-Y) axis compared to the red-green (R-G) axis. No statistically significant differences in B-Y and R-G PES were observed in the control group. This study shows that hypothyroidism affects color vision in humans, causing significant impairment in the B-Y color subsystem.

AB - There is evidence in the literature that hypofunction of the thyroid gland (hypothyroidism) affects color vision in rodents by influencing the production of the visual pigment opsin. The effect of hypothyroidism on color vision in humans has not been examined in any great detail. In this cross-sectional study we evaluated color discrimination using the Farnsworth-Munsell 100 hue test (FM-100) in 25 individuals with pre-treatment hypothyroidism (mean age 38±9.2 Yrs), and a control euthyroid group, n=26 (mean age 39.6±8.4 Yrs). There was no statistically significant difference in the total error score (TES) between the groups, but the hypothyroid group had a significantly greater partial error scores (PES) along the blue-yellow (B-Y) axis compared to the red-green (R-G) axis. No statistically significant differences in B-Y and R-G PES were observed in the control group. This study shows that hypothyroidism affects color vision in humans, causing significant impairment in the B-Y color subsystem.

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