Cognitive functioning in subjects with recent-onset psychosis from a low-middle-income environment: multiple-domain deficits and longitudinal evaluation.

Adriana de Mello Ayres, Marcia Scazufca, Paulo Rossi Menezes, Eduardo Yoshio Nakano, Ana Carolina B Regina, Maristela S Schaufelberger, Robin M Murray, Teresa Rushe, Philip K McGuire, Geraldo F Busatto

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    12 Citations (Scopus)

    Abstract

    Cognitive deficits are a key feature of recent-onset psychosis, but there is no consensus on whether such deficits are generalized or confined to specific domains. Besides, it is unclear whether cognitive deficits: a) are found in psychotic patients in samples from outside high-income countries; and b) whether they progress uniformly over time in schizophrenia and affective psychoses. We applied 12 tests organized into eight cognitive domains, comparing psychosis patients (n = 56, time from initial contact = 677.95+/-183.27 days) versus healthy controls (n=70) recruited from the same area of São Paulo, Brazil. Longitudinal comparisons (digit span and verbal fluency) were conducted between a previous assessment of the subjects carried out at their psychosis onset, and the current follow-up evaluation. Psychosis patients differed significantly from controls on five domains, most prominently on verbal memory. Cognitive deficits remained detectable in separate comparisons of the schizophrenia subgroup and, to a lesser extent, the affective psychosis subjects against controls. Longitudinal comparisons indicated significant improvement in schizophrenia, affective psychoses, and control subjects, with no significant group-by-time interactions. Our results reinforce the view that there are generalized cognitive deficits in association with recent-onset psychoses, particularly of non-affective nature, which persist over time.
    LanguageEnglish
    Pages157-64
    JournalPsychiatry research
    Volume179
    Issue number2
    Publication statusPublished - 2010

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    Psychotic Disorders
    Psychotic Affective Disorders
    Schizophrenia
    Brazil
    Consensus

    Cite this

    de Mello Ayres, A., Scazufca, M., Menezes, P. R., Nakano, E. Y., Regina, A. C. B., Schaufelberger, M. S., ... Busatto, G. F. (2010). Cognitive functioning in subjects with recent-onset psychosis from a low-middle-income environment: multiple-domain deficits and longitudinal evaluation. 179(2), 157-64.
    de Mello Ayres, Adriana ; Scazufca, Marcia ; Menezes, Paulo Rossi ; Nakano, Eduardo Yoshio ; Regina, Ana Carolina B ; Schaufelberger, Maristela S ; Murray, Robin M ; Rushe, Teresa ; McGuire, Philip K ; Busatto, Geraldo F. / Cognitive functioning in subjects with recent-onset psychosis from a low-middle-income environment: multiple-domain deficits and longitudinal evaluation. 2010 ; Vol. 179, No. 2. pp. 157-64.
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    title = "Cognitive functioning in subjects with recent-onset psychosis from a low-middle-income environment: multiple-domain deficits and longitudinal evaluation.",
    abstract = "Cognitive deficits are a key feature of recent-onset psychosis, but there is no consensus on whether such deficits are generalized or confined to specific domains. Besides, it is unclear whether cognitive deficits: a) are found in psychotic patients in samples from outside high-income countries; and b) whether they progress uniformly over time in schizophrenia and affective psychoses. We applied 12 tests organized into eight cognitive domains, comparing psychosis patients (n = 56, time from initial contact = 677.95+/-183.27 days) versus healthy controls (n=70) recruited from the same area of S{\~a}o Paulo, Brazil. Longitudinal comparisons (digit span and verbal fluency) were conducted between a previous assessment of the subjects carried out at their psychosis onset, and the current follow-up evaluation. Psychosis patients differed significantly from controls on five domains, most prominently on verbal memory. Cognitive deficits remained detectable in separate comparisons of the schizophrenia subgroup and, to a lesser extent, the affective psychosis subjects against controls. Longitudinal comparisons indicated significant improvement in schizophrenia, affective psychoses, and control subjects, with no significant group-by-time interactions. Our results reinforce the view that there are generalized cognitive deficits in association with recent-onset psychoses, particularly of non-affective nature, which persist over time.",
    author = "{de Mello Ayres}, Adriana and Marcia Scazufca and Menezes, {Paulo Rossi} and Nakano, {Eduardo Yoshio} and Regina, {Ana Carolina B} and Schaufelberger, {Maristela S} and Murray, {Robin M} and Teresa Rushe and McGuire, {Philip K} and Busatto, {Geraldo F}",
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    de Mello Ayres, A, Scazufca, M, Menezes, PR, Nakano, EY, Regina, ACB, Schaufelberger, MS, Murray, RM, Rushe, T, McGuire, PK & Busatto, GF 2010, 'Cognitive functioning in subjects with recent-onset psychosis from a low-middle-income environment: multiple-domain deficits and longitudinal evaluation.', vol. 179, no. 2, pp. 157-64.

    Cognitive functioning in subjects with recent-onset psychosis from a low-middle-income environment: multiple-domain deficits and longitudinal evaluation. / de Mello Ayres, Adriana; Scazufca, Marcia; Menezes, Paulo Rossi; Nakano, Eduardo Yoshio; Regina, Ana Carolina B; Schaufelberger, Maristela S; Murray, Robin M; Rushe, Teresa; McGuire, Philip K; Busatto, Geraldo F.

    Vol. 179, No. 2, 2010, p. 157-64.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Cognitive functioning in subjects with recent-onset psychosis from a low-middle-income environment: multiple-domain deficits and longitudinal evaluation.

    AU - de Mello Ayres, Adriana

    AU - Scazufca, Marcia

    AU - Menezes, Paulo Rossi

    AU - Nakano, Eduardo Yoshio

    AU - Regina, Ana Carolina B

    AU - Schaufelberger, Maristela S

    AU - Murray, Robin M

    AU - Rushe, Teresa

    AU - McGuire, Philip K

    AU - Busatto, Geraldo F

    PY - 2010

    Y1 - 2010

    N2 - Cognitive deficits are a key feature of recent-onset psychosis, but there is no consensus on whether such deficits are generalized or confined to specific domains. Besides, it is unclear whether cognitive deficits: a) are found in psychotic patients in samples from outside high-income countries; and b) whether they progress uniformly over time in schizophrenia and affective psychoses. We applied 12 tests organized into eight cognitive domains, comparing psychosis patients (n = 56, time from initial contact = 677.95+/-183.27 days) versus healthy controls (n=70) recruited from the same area of São Paulo, Brazil. Longitudinal comparisons (digit span and verbal fluency) were conducted between a previous assessment of the subjects carried out at their psychosis onset, and the current follow-up evaluation. Psychosis patients differed significantly from controls on five domains, most prominently on verbal memory. Cognitive deficits remained detectable in separate comparisons of the schizophrenia subgroup and, to a lesser extent, the affective psychosis subjects against controls. Longitudinal comparisons indicated significant improvement in schizophrenia, affective psychoses, and control subjects, with no significant group-by-time interactions. Our results reinforce the view that there are generalized cognitive deficits in association with recent-onset psychoses, particularly of non-affective nature, which persist over time.

    AB - Cognitive deficits are a key feature of recent-onset psychosis, but there is no consensus on whether such deficits are generalized or confined to specific domains. Besides, it is unclear whether cognitive deficits: a) are found in psychotic patients in samples from outside high-income countries; and b) whether they progress uniformly over time in schizophrenia and affective psychoses. We applied 12 tests organized into eight cognitive domains, comparing psychosis patients (n = 56, time from initial contact = 677.95+/-183.27 days) versus healthy controls (n=70) recruited from the same area of São Paulo, Brazil. Longitudinal comparisons (digit span and verbal fluency) were conducted between a previous assessment of the subjects carried out at their psychosis onset, and the current follow-up evaluation. Psychosis patients differed significantly from controls on five domains, most prominently on verbal memory. Cognitive deficits remained detectable in separate comparisons of the schizophrenia subgroup and, to a lesser extent, the affective psychosis subjects against controls. Longitudinal comparisons indicated significant improvement in schizophrenia, affective psychoses, and control subjects, with no significant group-by-time interactions. Our results reinforce the view that there are generalized cognitive deficits in association with recent-onset psychoses, particularly of non-affective nature, which persist over time.

    M3 - Article

    VL - 179

    SP - 157

    EP - 164

    IS - 2

    ER -

    de Mello Ayres A, Scazufca M, Menezes PR, Nakano EY, Regina ACB, Schaufelberger MS et al. Cognitive functioning in subjects with recent-onset psychosis from a low-middle-income environment: multiple-domain deficits and longitudinal evaluation. 2010;179(2):157-64.