Clinical Symptoms of Arboviruses in Mexico

Sushmitha Ananth, Nistha Shrestha, Jesús A. Treviño C., Uyen-sa Nguyen, Ubydul Haque, Aracely Angulo-molina, Uriel A. Lopez-lemus, Jailos Lubinda, Rashed Md. Sharif, Rafdzah Ahmad Zaki, Rosa María Sánchez Casas, Diana Cervantes, Rajesh Nandy

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)
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Arboviruses such as Chikungunya (CHIKV), Dengue (DENV), and Zika virus (ZIKV) have emerged as a significant public health concern in Mexico. The existing literature lacks evidence regarding the dispersion of arboviruses, thereby limiting public health policy’s ability to integrate the diagnosis, management, and prevention. This study seeks to reveal the clinical symptoms of CHIK, DENV, and ZIKV by age group, region, sex, and time across Mexico. The confirmed cases of CHIKV, DENV, and ZIKV were compiled from January 2012 to March 2020. Demographic characteristics analyzed significant clinical symptoms of confirmed cases. Multinomial logistic regression was used to assess the association between clinical symptoms and geographical regions. Females and individuals aged 15 and older had higher rates of reported significant symptoms across all three arboviruses. DENV showed a temporal variation of symptoms by regions 3 and 5, whereas ZIKV presented temporal variables in regions 2 and 4. This study revealed unique and overlapping symptoms between CHIKV, DENV, and ZIKV. However, the differentiation of CHIKV, DENV, and ZIKV is difficult, and diagnostic facilities are not available in rural areas. There is a need for adequately trained healthcare staff alongside well-equipped lab facilities, including hematological tests and imaging facilities.
Original languageEnglish
Article number964
Pages (from-to)1-16
Number of pages16
Issue number11
Early online date19 Nov 2020
Publication statusPublished online - 19 Nov 2020

Bibliographical note

Funding Information:
Funding: UH was supported by the Research Council of Norway (grant # 281077).

Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.


  • Chikungunya
  • Dengue
  • Zika virus
  • epidemiology
  • public health
  • Epidemiology
  • Public health


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