Clinical diagnostics for homocysteine: a rogue amino acid?

LAA Newton, K Sandhu, C Livingstone, R Leslie, J Davis

    Research output: Contribution to journal › Article

    9 Citations (Scopus)

    Abstract

    Homocysteine has gathered considerable interest in recent years after being implicated in the pathogenesis of various clinical conditions. It has been an elusive target with many conflicting studies casting some confusion over its significance, and much more needs to be done to ascertain its pathophysiological role especially with respect to regimes aimed at lowering its plasma concentration. Central to this is the development of robust analytical strategies for its determination. This review summarizes the clinical relevance of homocysteine as a diagnostic marker of disease and explores and critically assesses the detection methods that have been developed.
    LanguageEnglish
    Pages489-500
    JournalExpert Review of Molecular Diagnostics
    Volume10
    Issue number4
    DOIs
    Publication statusPublished - May 2010

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    Homocysteine
    Amino Acids

    Cite this

    Newton, LAA ; Sandhu, K ; Livingstone, C ; Leslie, R ; Davis, J. / Clinical diagnostics for homocysteine: a rogue amino acid?. In: Expert Review of Molecular Diagnostics. 2010 ; Vol. 10, No. 4. pp. 489-500.
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    title = "Clinical diagnostics for homocysteine: a rogue amino acid?",
    abstract = "Homocysteine has gathered considerable interest in recent years after being implicated in the pathogenesis of various clinical conditions. It has been an elusive target with many conflicting studies casting some confusion over its significance, and much more needs to be done to ascertain its pathophysiological role especially with respect to regimes aimed at lowering its plasma concentration. Central to this is the development of robust analytical strategies for its determination. This review summarizes the clinical relevance of homocysteine as a diagnostic marker of disease and explores and critically assesses the detection methods that have been developed.",
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    Newton, LAA, Sandhu, K, Livingstone, C, Leslie, R & Davis, J 2010, 'Clinical diagnostics for homocysteine: a rogue amino acid?', Expert Review of Molecular Diagnostics, vol. 10, no. 4, pp. 489-500. https://doi.org/10.1586/ERM.10.19

    Clinical diagnostics for homocysteine: a rogue amino acid? / Newton, LAA; Sandhu, K; Livingstone, C; Leslie, R; Davis, J.

    In: Expert Review of Molecular Diagnostics, Vol. 10, No. 4, 05.2010, p. 489-500.

    Research output: Contribution to journal › Article

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    AU - Leslie, R

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    N2 - Homocysteine has gathered considerable interest in recent years after being implicated in the pathogenesis of various clinical conditions. It has been an elusive target with many conflicting studies casting some confusion over its significance, and much more needs to be done to ascertain its pathophysiological role especially with respect to regimes aimed at lowering its plasma concentration. Central to this is the development of robust analytical strategies for its determination. This review summarizes the clinical relevance of homocysteine as a diagnostic marker of disease and explores and critically assesses the detection methods that have been developed.

    AB - Homocysteine has gathered considerable interest in recent years after being implicated in the pathogenesis of various clinical conditions. It has been an elusive target with many conflicting studies casting some confusion over its significance, and much more needs to be done to ascertain its pathophysiological role especially with respect to regimes aimed at lowering its plasma concentration. Central to this is the development of robust analytical strategies for its determination. This review summarizes the clinical relevance of homocysteine as a diagnostic marker of disease and explores and critically assesses the detection methods that have been developed.

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    T2 - Expert Review of Molecular Diagnostics

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    Newton LAA, Sandhu K, Livingstone C, Leslie R, Davis J. Clinical diagnostics for homocysteine: a rogue amino acid? Expert Review of Molecular Diagnostics. 2010 May;10(4):489-500. https://doi.org/10.1586/ERM.10.19

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