TY - JOUR
T1 - Circulating proinflammatory cytokines and N-terminal pro-brain natriuretic peptide significantly decrease with recovery of left ventricular function in patients with dilated cardiomyopathy
AU - Ahmad, Shamim
AU - Otaal, Parminder Singh
AU - Rai, Taranjit Singh
AU - Bahl, Ajay
AU - Saikia, Uma Nahar
AU - Manoj, Rohit K.
AU - Thungapathra, M.
AU - Talwar, Kewal K.
AU - Khullar, Madhu
PY - 2009/1/1
Y1 - 2009/1/1
N2 - Background: Increased levels of TNF-α IL-6, their soluble receptors, and NT-proBNP have been observed in patients with dilated cardiomyopathy (DCM). In the present study, we assessed the possible involvement of proinflammatory cytokines and their soluble receptors with and without recovery of LV function in DCM patients. Methods and results: Forty patients with DCM were enrolled and divided into two groups: Group I consisted of DCM patients (n = 30) whose left ventricular ejection fraction (LVEF) had not recovered on follow up and Group II comprised DCM patients (n = 10) whose LVEF had recovered. Ten healthy subjects were included as controls (Group III). TNF-α IL-6,TNFR1, TNFRII, gp130, and NT-proBNP levels were significantly increased in Group I and were significantly lower in patients with LVEF recovery as compared to those without recovery of LVEF (P < 0.05). Conclusion: Circulating TNF-α, IL-6, and NT-proBNP appear to correlate with the LV function recovery of patients with DCM and could be used as prognostic biomarkers.
AB - Background: Increased levels of TNF-α IL-6, their soluble receptors, and NT-proBNP have been observed in patients with dilated cardiomyopathy (DCM). In the present study, we assessed the possible involvement of proinflammatory cytokines and their soluble receptors with and without recovery of LV function in DCM patients. Methods and results: Forty patients with DCM were enrolled and divided into two groups: Group I consisted of DCM patients (n = 30) whose left ventricular ejection fraction (LVEF) had not recovered on follow up and Group II comprised DCM patients (n = 10) whose LVEF had recovered. Ten healthy subjects were included as controls (Group III). TNF-α IL-6,TNFR1, TNFRII, gp130, and NT-proBNP levels were significantly increased in Group I and were significantly lower in patients with LVEF recovery as compared to those without recovery of LVEF (P < 0.05). Conclusion: Circulating TNF-α, IL-6, and NT-proBNP appear to correlate with the LV function recovery of patients with DCM and could be used as prognostic biomarkers.
KW - Dilated cardiomyopathy
KW - LVEF recovery
KW - Nt-proBNP
KW - Proinflammatory cytokines
UR - http://www.scopus.com/inward/record.url?scp=61549119444&partnerID=8YFLogxK
U2 - 10.1007/s11010-008-9992-1
DO - 10.1007/s11010-008-9992-1
M3 - Article
C2 - 19107325
AN - SCOPUS:61549119444
SN - 0300-8177
VL - 324
SP - 139
EP - 145
JO - Molecular and Cellular Biochemistry
JF - Molecular and Cellular Biochemistry
IS - 1-2
ER -