Circulating proinflammatory cytokines and N-terminal pro-brain natriuretic peptide significantly decrease with recovery of left ventricular function in patients with dilated cardiomyopathy

Shamim Ahmad, Parminder Singh Otaal, Taranjit Singh Rai, Ajay Bahl, Uma Nahar Saikia, Rohit K. Manoj, M. Thungapathra, Kewal K. Talwar, Madhu Khullar

Research output: Contribution to journalArticle

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Abstract

Background: Increased levels of TNF-α IL-6, their soluble receptors, and NT-proBNP have been observed in patients with dilated cardiomyopathy (DCM). In the present study, we assessed the possible involvement of proinflammatory cytokines and their soluble receptors with and without recovery of LV function in DCM patients. Methods and results: Forty patients with DCM were enrolled and divided into two groups: Group I consisted of DCM patients (n = 30) whose left ventricular ejection fraction (LVEF) had not recovered on follow up and Group II comprised DCM patients (n = 10) whose LVEF had recovered. Ten healthy subjects were included as controls (Group III). TNF-α IL-6,TNFR1, TNFRII, gp130, and NT-proBNP levels were significantly increased in Group I and were significantly lower in patients with LVEF recovery as compared to those without recovery of LVEF (P < 0.05). Conclusion: Circulating TNF-α, IL-6, and NT-proBNP appear to correlate with the LV function recovery of patients with DCM and could be used as prognostic biomarkers.

LanguageEnglish
Pages139-145
Number of pages7
JournalMolecular and Cellular Biochemistry
Volume324
Issue number1-2
DOIs
Publication statusPublished - 1 Jan 2009

Fingerprint

Brain Natriuretic Peptide
Dilated Cardiomyopathy
Left Ventricular Function
Cytokines
Recovery
Interleukin-6
Tumor Necrosis Factor-alpha
Stroke Volume
Receptors, Tumor Necrosis Factor, Type I
Recovery of Function
Biomarkers
Healthy Volunteers
pro-brain natriuretic peptide (1-76)
Control Groups

Keywords

  • Dilated cardiomyopathy
  • LVEF recovery
  • Nt-proBNP
  • Proinflammatory cytokines

Cite this

Ahmad, Shamim ; Otaal, Parminder Singh ; Rai, Taranjit Singh ; Bahl, Ajay ; Saikia, Uma Nahar ; Manoj, Rohit K. ; Thungapathra, M. ; Talwar, Kewal K. ; Khullar, Madhu. / Circulating proinflammatory cytokines and N-terminal pro-brain natriuretic peptide significantly decrease with recovery of left ventricular function in patients with dilated cardiomyopathy. In: Molecular and Cellular Biochemistry. 2009 ; Vol. 324, No. 1-2. pp. 139-145.
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abstract = "Background: Increased levels of TNF-α IL-6, their soluble receptors, and NT-proBNP have been observed in patients with dilated cardiomyopathy (DCM). In the present study, we assessed the possible involvement of proinflammatory cytokines and their soluble receptors with and without recovery of LV function in DCM patients. Methods and results: Forty patients with DCM were enrolled and divided into two groups: Group I consisted of DCM patients (n = 30) whose left ventricular ejection fraction (LVEF) had not recovered on follow up and Group II comprised DCM patients (n = 10) whose LVEF had recovered. Ten healthy subjects were included as controls (Group III). TNF-α IL-6,TNFR1, TNFRII, gp130, and NT-proBNP levels were significantly increased in Group I and were significantly lower in patients with LVEF recovery as compared to those without recovery of LVEF (P < 0.05). Conclusion: Circulating TNF-α, IL-6, and NT-proBNP appear to correlate with the LV function recovery of patients with DCM and could be used as prognostic biomarkers.",
keywords = "Dilated cardiomyopathy, LVEF recovery, Nt-proBNP, Proinflammatory cytokines",
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Circulating proinflammatory cytokines and N-terminal pro-brain natriuretic peptide significantly decrease with recovery of left ventricular function in patients with dilated cardiomyopathy. / Ahmad, Shamim; Otaal, Parminder Singh; Rai, Taranjit Singh; Bahl, Ajay; Saikia, Uma Nahar; Manoj, Rohit K.; Thungapathra, M.; Talwar, Kewal K.; Khullar, Madhu.

In: Molecular and Cellular Biochemistry, Vol. 324, No. 1-2, 01.01.2009, p. 139-145.

Research output: Contribution to journalArticle

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AU - Ahmad, Shamim

AU - Otaal, Parminder Singh

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AU - Bahl, Ajay

AU - Saikia, Uma Nahar

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N2 - Background: Increased levels of TNF-α IL-6, their soluble receptors, and NT-proBNP have been observed in patients with dilated cardiomyopathy (DCM). In the present study, we assessed the possible involvement of proinflammatory cytokines and their soluble receptors with and without recovery of LV function in DCM patients. Methods and results: Forty patients with DCM were enrolled and divided into two groups: Group I consisted of DCM patients (n = 30) whose left ventricular ejection fraction (LVEF) had not recovered on follow up and Group II comprised DCM patients (n = 10) whose LVEF had recovered. Ten healthy subjects were included as controls (Group III). TNF-α IL-6,TNFR1, TNFRII, gp130, and NT-proBNP levels were significantly increased in Group I and were significantly lower in patients with LVEF recovery as compared to those without recovery of LVEF (P < 0.05). Conclusion: Circulating TNF-α, IL-6, and NT-proBNP appear to correlate with the LV function recovery of patients with DCM and could be used as prognostic biomarkers.

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