Chronic respiratory diseases: An introduction and need for novel drug delivery approaches

Shakti D. Shukla, Kanth Swaroop Vanka, Anne Chavelier, Madhur D. Shastri, Murtaza M. Tambuwala, Hamid A. Bakshi, Kavita Pabreja, Malik Q. Mahmood, Ronan F. O’toole

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Globally, chronic respiratory diseases (CRDs), both communicable and noncommunicable, are among the leading causes of mortality, morbidity, economic and societal burden, and disability-adjusted life years (DALYs). CRDs affect multiple components of respiratory system, including the airways, parenchyma, and pulmonary vasculature. Although noncommunicable respiratory diseases, such as asthma, chronic obstructive pulmonary disease (COPD), interstitial lung disease (ILD), cystic fibrosis (CF), and lung cancer (LC), account for enormous disease burden, the currently available therapies only focus on alleviating the symptoms of diseases rather than providing optimal treatment and/or prevention. Similarly a major respiratory communicable disease, that is, tuberculosis (TB), is associated with the challenge of increasingly developing antibiotic resistance in the bacterial pathogen Mycobacterium tuberculosis. In light of these challenges, we aim to summarize the underlying molecular and cellular mechanisms that lead to hallmark pathophysiology of CRDs. Moreover, we will also highlight the limitations of current therapeutic strategies and explore novel drug delivery options that may be potentially more effective in the management of CRDs.
Original languageEnglish
Title of host publicationTargeting Chronic Inflammatory Lung Diseases Using Advanced Drug Delivery Systems
PublisherElsevier
Chapter1
Pages1-31
Number of pages30
ISBN (Print)9780128206584
DOIs
Publication statusPublished - 18 Sep 2020

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    Shukla, S. D., Swaroop Vanka, K., Chavelier, A., Shastri, M. D., Tambuwala, M. M., Bakshi, H. A., Pabreja, K., Mahmood, M. Q., & O’toole, R. F. (2020). Chronic respiratory diseases: An introduction and need for novel drug delivery approaches. In Targeting Chronic Inflammatory Lung Diseases Using Advanced Drug Delivery Systems (pp. 1-31). Elsevier. https://doi.org/10.1016/B978-0-12-820658-4.00001-7