Chronic Inflammation’s Transformation to Cancer: A Nanotherapeutic Paradigm

Sayed Sartaj Sohrab, Riya Raj, Amka Nagar, Susan Hawthorne, Ana Cláudia Paiva-Santos, Mohammad Amjad Kamal, Mai M. El-Daly, Esam I. Azhar, Ankur Sharma, Subramanian Balakumar (Editor), Kai Zheng (Editor)

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)
3 Downloads (Pure)


The body’s normal immune response against any invading pathogen that causes infection in the body results in inflammation. The sudden transformation in inflammation leads to the rise of inflammatory diseases such as chronic inflammatory bowel disease, autoimmune disorders, and colorectal cancer (different types of cancer develop at the site of chronic infection and inflammation). Inflammation results in two ways: short-term inflammation i.e., non-specific, involves the action of various immune cells; the other results in long-term reactions lasting for months or years. It is specific and causes angiogenesis, fibrosis, tissue destruction, and cancer progression at the site of inflammation. Cancer progression relies on the interaction between the host microenvironment and tumor cells along with the inflammatory responses, fibroblast, and vascular cells. The two pathways that have been identified connecting inflammation and cancer are the extrinsic and intrinsic pathways. Both have their own specific role in linking inflammation to cancer, involving various transcription factors such as Nuclear factor kappa B, Activator of transcription, Single transducer, and Hypoxia-inducible factor, which in turn regulates the inflammatory responses via Soluble mediators cytokines (such as Interleukin-6, Hematopoietin-1/Erythropoietin, and tumor necrosis factor), chemokines (such as Cyclooxygenase-2, C-X-C Motif chemokines ligand-8, and IL-8), inflammatory cells, cellular components (such as suppressor cells derived from myeloid, tumor-associated macrophage, and acidophils), and promotes tumorigenesis. The treatment of these chronic inflammatory diseases is challenging and needs early detection and diagnosis. Nanotechnology is a booming field nowadays for its rapid action and easy penetration inside the infected destined cells. Nanoparticles are widely classified into different categories based on their different factors and properties such as size, shape, cytotoxicity, and others. Nanoparticles emerged as excellent with highly progressive medical inventions to cure diseases such as cancer, inflammatory diseases, and others. Nanoparticles have shown higher binding capacity with the biomolecules in inflammation reduction and lowers the oxidative stress inside tissue/cells. In this review, we have overall discussed inflammatory pathways that link inflammation to cancer, major inflammatory diseases, and the potent action of nanoparticles in chronic inflammation-related diseases.
Original languageEnglish
Article number4413
Pages (from-to)1-19
Number of pages20
Issue number11
Early online date29 May 2023
Publication statusPublished online - 29 May 2023

Bibliographical note

Funding Information:
This review work was funded by Institutional Fund Projects under grant No. (IFPIP:513-141-1443) and the APC was funded from this grant. The authors gratefully acknowledge the financial support provided by the ministry of Education and King Abdulaziz University, DSR, Jeddah, Saudi: IFPIP:513-141-1443.

Funding Information:
The authors gratefully acknowledge the technical and financial support provided by the Ministry of Education and King Abdulaziz University, DSR, Jeddah, Saudi Arabia.

Publisher Copyright:
© 2023 by the authors.


  • cancer
  • inflammatory pathways
  • drug delivery
  • inflammation
  • nanoparticles


Dive into the research topics of 'Chronic Inflammation’s Transformation to Cancer: A Nanotherapeutic Paradigm'. Together they form a unique fingerprint.

Cite this