Childhood Trauma and Hippocampal and Amygdalar Volumes in First-Episode Psychosis.

Katrina Hoy, Suzanne Barrett, Ciaran Shannon, Clodagh Campbell, David Watson, Teresa Rushe, Mark Shevlin, Feng Bai, Stephen Cooper, Ciaran Mulholland

    Research output: Contribution to journalArticle

    51 Citations (Scopus)

    Abstract

    Objective: A history of childhood trauma is common in individuals who later develop psychosis. Similar neuroanatomical abnormalities are observed in people who have been exposed to childhood trauma and people with psychosis. However, the relationship between childhood trauma and such abnormalities in psychosis has not been investigated. This study aimed to explore the association between the experience of childhood trauma and hippocampal and amygdalar volumes in a first-episode psychosis (FEP) population. Methods: The study employed an observational retrospective design. Twenty-one individuals, who had previously undergone magnetic resonance imaging procedures as part of the longitudinal Northern Ireland First-Episode Psychosis Study, completed measures assessing traumatic experiences and were included in the analysis. Data were subject to correlation analyses (r and r(pb)). Potential confounding variables (age at FEP and delay to scan from recruitment) were selected a priori for inclusion in multiple regression analyses. Results: There was a high prevalence of lifetime (95%) and childhood (76%) trauma in the sample. The experience of childhood trauma was a significant predictor of left hippocampal volume, although age at FEP also significantly contributed to this model. There was no significant association between predictor variables and right hippocampal volume. The experience of childhood trauma was a significant predictor of right and total amygdalar volumes and the hippocampal/amygdalar complex volume as a whole. Conclusions: The findings indicate that childhood trauma is associated with neuroanatomical measures in FEP. Future research controlling for childhood traumatic experiences may contribute to explaining brain morphology in people with psychosis.
    LanguageEnglish
    JournalSchizophrenia Bulletin
    VolumeEpub
    DOIs
    Publication statusPublished - 28 Jul 2011

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    Psychotic Disorders
    Wounds and Injuries
    Northern Ireland
    Confounding Factors (Epidemiology)
    Observational Studies
    Regression Analysis
    Magnetic Resonance Imaging
    Brain
    Population

    Cite this

    Hoy, K., Barrett, S., Shannon, C., Campbell, C., Watson, D., Rushe, T., ... Mulholland, C. (2011). Childhood Trauma and Hippocampal and Amygdalar Volumes in First-Episode Psychosis. Schizophrenia Bulletin, Epub. https://doi.org/10.1093/schbul/sbr085
    Hoy, Katrina ; Barrett, Suzanne ; Shannon, Ciaran ; Campbell, Clodagh ; Watson, David ; Rushe, Teresa ; Shevlin, Mark ; Bai, Feng ; Cooper, Stephen ; Mulholland, Ciaran. / Childhood Trauma and Hippocampal and Amygdalar Volumes in First-Episode Psychosis. In: Schizophrenia Bulletin. 2011 ; Vol. Epub.
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    title = "Childhood Trauma and Hippocampal and Amygdalar Volumes in First-Episode Psychosis.",
    abstract = "Objective: A history of childhood trauma is common in individuals who later develop psychosis. Similar neuroanatomical abnormalities are observed in people who have been exposed to childhood trauma and people with psychosis. However, the relationship between childhood trauma and such abnormalities in psychosis has not been investigated. This study aimed to explore the association between the experience of childhood trauma and hippocampal and amygdalar volumes in a first-episode psychosis (FEP) population. Methods: The study employed an observational retrospective design. Twenty-one individuals, who had previously undergone magnetic resonance imaging procedures as part of the longitudinal Northern Ireland First-Episode Psychosis Study, completed measures assessing traumatic experiences and were included in the analysis. Data were subject to correlation analyses (r and r(pb)). Potential confounding variables (age at FEP and delay to scan from recruitment) were selected a priori for inclusion in multiple regression analyses. Results: There was a high prevalence of lifetime (95{\%}) and childhood (76{\%}) trauma in the sample. The experience of childhood trauma was a significant predictor of left hippocampal volume, although age at FEP also significantly contributed to this model. There was no significant association between predictor variables and right hippocampal volume. The experience of childhood trauma was a significant predictor of right and total amygdalar volumes and the hippocampal/amygdalar complex volume as a whole. Conclusions: The findings indicate that childhood trauma is associated with neuroanatomical measures in FEP. Future research controlling for childhood traumatic experiences may contribute to explaining brain morphology in people with psychosis.",
    author = "Katrina Hoy and Suzanne Barrett and Ciaran Shannon and Clodagh Campbell and David Watson and Teresa Rushe and Mark Shevlin and Feng Bai and Stephen Cooper and Ciaran Mulholland",
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    Hoy, K, Barrett, S, Shannon, C, Campbell, C, Watson, D, Rushe, T, Shevlin, M, Bai, F, Cooper, S & Mulholland, C 2011, 'Childhood Trauma and Hippocampal and Amygdalar Volumes in First-Episode Psychosis.', Schizophrenia Bulletin, vol. Epub. https://doi.org/10.1093/schbul/sbr085

    Childhood Trauma and Hippocampal and Amygdalar Volumes in First-Episode Psychosis. / Hoy, Katrina; Barrett, Suzanne; Shannon, Ciaran; Campbell, Clodagh; Watson, David; Rushe, Teresa; Shevlin, Mark; Bai, Feng; Cooper, Stephen; Mulholland, Ciaran.

    In: Schizophrenia Bulletin, Vol. Epub, 28.07.2011.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Childhood Trauma and Hippocampal and Amygdalar Volumes in First-Episode Psychosis.

    AU - Hoy, Katrina

    AU - Barrett, Suzanne

    AU - Shannon, Ciaran

    AU - Campbell, Clodagh

    AU - Watson, David

    AU - Rushe, Teresa

    AU - Shevlin, Mark

    AU - Bai, Feng

    AU - Cooper, Stephen

    AU - Mulholland, Ciaran

    PY - 2011/7/28

    Y1 - 2011/7/28

    N2 - Objective: A history of childhood trauma is common in individuals who later develop psychosis. Similar neuroanatomical abnormalities are observed in people who have been exposed to childhood trauma and people with psychosis. However, the relationship between childhood trauma and such abnormalities in psychosis has not been investigated. This study aimed to explore the association between the experience of childhood trauma and hippocampal and amygdalar volumes in a first-episode psychosis (FEP) population. Methods: The study employed an observational retrospective design. Twenty-one individuals, who had previously undergone magnetic resonance imaging procedures as part of the longitudinal Northern Ireland First-Episode Psychosis Study, completed measures assessing traumatic experiences and were included in the analysis. Data were subject to correlation analyses (r and r(pb)). Potential confounding variables (age at FEP and delay to scan from recruitment) were selected a priori for inclusion in multiple regression analyses. Results: There was a high prevalence of lifetime (95%) and childhood (76%) trauma in the sample. The experience of childhood trauma was a significant predictor of left hippocampal volume, although age at FEP also significantly contributed to this model. There was no significant association between predictor variables and right hippocampal volume. The experience of childhood trauma was a significant predictor of right and total amygdalar volumes and the hippocampal/amygdalar complex volume as a whole. Conclusions: The findings indicate that childhood trauma is associated with neuroanatomical measures in FEP. Future research controlling for childhood traumatic experiences may contribute to explaining brain morphology in people with psychosis.

    AB - Objective: A history of childhood trauma is common in individuals who later develop psychosis. Similar neuroanatomical abnormalities are observed in people who have been exposed to childhood trauma and people with psychosis. However, the relationship between childhood trauma and such abnormalities in psychosis has not been investigated. This study aimed to explore the association between the experience of childhood trauma and hippocampal and amygdalar volumes in a first-episode psychosis (FEP) population. Methods: The study employed an observational retrospective design. Twenty-one individuals, who had previously undergone magnetic resonance imaging procedures as part of the longitudinal Northern Ireland First-Episode Psychosis Study, completed measures assessing traumatic experiences and were included in the analysis. Data were subject to correlation analyses (r and r(pb)). Potential confounding variables (age at FEP and delay to scan from recruitment) were selected a priori for inclusion in multiple regression analyses. Results: There was a high prevalence of lifetime (95%) and childhood (76%) trauma in the sample. The experience of childhood trauma was a significant predictor of left hippocampal volume, although age at FEP also significantly contributed to this model. There was no significant association between predictor variables and right hippocampal volume. The experience of childhood trauma was a significant predictor of right and total amygdalar volumes and the hippocampal/amygdalar complex volume as a whole. Conclusions: The findings indicate that childhood trauma is associated with neuroanatomical measures in FEP. Future research controlling for childhood traumatic experiences may contribute to explaining brain morphology in people with psychosis.

    U2 - 10.1093/schbul/sbr085

    DO - 10.1093/schbul/sbr085

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    VL - Epub

    JO - Schizophrenia Bulletin

    T2 - Schizophrenia Bulletin

    JF - Schizophrenia Bulletin

    SN - 0586-7614

    ER -