Chickpea (Cicer arietinum) and Other Plant-Derived Protease Inhibitor Concentrates Inhibit Breast and Prostate Cancer Cell Proliferation In Vitro.

Pamela Magee, Richard Owusu, Mark McCann, Chris I. R. Gill, Ian R Rowland

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18 Citations (Scopus)

Abstract

The soybean-derived protease inhibitor, Bowman-Birk inhibitor(BBI), is currently showing great promise as a novel cancerchemopreventive agent. In contrast to the wealth of researchconducted on this compound, the anticancer effects of proteaseinhibitors isolated from other leguminous sources have receivedlimited attention. In the current study, 7 protease inhibitor concentrates(PICs) were isolated from various leguminous sources(including soybean) and characterized. The effects of PICs on theproliferation of breast and prostate cancer cells were investigatedin vitro. Chickpea PIC significantly inhibited the viability ofMDAMB-231 breast cancer and PC-3 and LNCaP prostate cancer cellsat all concentrations tested (25–400 μg/ml). In addition, kidneybean (200, 400 μg/ml), soybean (50, 100 μg/ml), and mungbean(100, 200 μg/ml) PICs inhibited LNCaP cell viability. These findingssuggest that leguminous PICs may possess similar anticancerproperties to that of soybean BBI and deserve further study aspossible chemopreventive agents.
LanguageEnglish
JournalNutrition and cancer
Volume1-8
DOIs
Publication statusPublished - 2012

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Cicer
Protease Inhibitors
Prostatic Neoplasms
Soybeans
Cell Proliferation
Breast Neoplasms
Serpin E2
Cell Survival
In Vitro Techniques

Cite this

@article{3547961e7bf049a4ace11a8979f0bc37,
title = "Chickpea (Cicer arietinum) and Other Plant-Derived Protease Inhibitor Concentrates Inhibit Breast and Prostate Cancer Cell Proliferation In Vitro.",
abstract = "The soybean-derived protease inhibitor, Bowman-Birk inhibitor(BBI), is currently showing great promise as a novel cancerchemopreventive agent. In contrast to the wealth of researchconducted on this compound, the anticancer effects of proteaseinhibitors isolated from other leguminous sources have receivedlimited attention. In the current study, 7 protease inhibitor concentrates(PICs) were isolated from various leguminous sources(including soybean) and characterized. The effects of PICs on theproliferation of breast and prostate cancer cells were investigatedin vitro. Chickpea PIC significantly inhibited the viability ofMDAMB-231 breast cancer and PC-3 and LNCaP prostate cancer cellsat all concentrations tested (25–400 μg/ml). In addition, kidneybean (200, 400 μg/ml), soybean (50, 100 μg/ml), and mungbean(100, 200 μg/ml) PICs inhibited LNCaP cell viability. These findingssuggest that leguminous PICs may possess similar anticancerproperties to that of soybean BBI and deserve further study aspossible chemopreventive agents.",
author = "Pamela Magee and Richard Owusu and Mark McCann and Gill, {Chris I. R.} and Rowland, {Ian R}",
year = "2012",
doi = "10.1080/01635581.2012.688914",
language = "English",
volume = "1-8",
journal = "Nutrition and Cancer - An International Journal",
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TY - JOUR

T1 - Chickpea (Cicer arietinum) and Other Plant-Derived Protease Inhibitor Concentrates Inhibit Breast and Prostate Cancer Cell Proliferation In Vitro.

AU - Magee, Pamela

AU - Owusu, Richard

AU - McCann, Mark

AU - Gill, Chris I. R.

AU - Rowland, Ian R

PY - 2012

Y1 - 2012

N2 - The soybean-derived protease inhibitor, Bowman-Birk inhibitor(BBI), is currently showing great promise as a novel cancerchemopreventive agent. In contrast to the wealth of researchconducted on this compound, the anticancer effects of proteaseinhibitors isolated from other leguminous sources have receivedlimited attention. In the current study, 7 protease inhibitor concentrates(PICs) were isolated from various leguminous sources(including soybean) and characterized. The effects of PICs on theproliferation of breast and prostate cancer cells were investigatedin vitro. Chickpea PIC significantly inhibited the viability ofMDAMB-231 breast cancer and PC-3 and LNCaP prostate cancer cellsat all concentrations tested (25–400 μg/ml). In addition, kidneybean (200, 400 μg/ml), soybean (50, 100 μg/ml), and mungbean(100, 200 μg/ml) PICs inhibited LNCaP cell viability. These findingssuggest that leguminous PICs may possess similar anticancerproperties to that of soybean BBI and deserve further study aspossible chemopreventive agents.

AB - The soybean-derived protease inhibitor, Bowman-Birk inhibitor(BBI), is currently showing great promise as a novel cancerchemopreventive agent. In contrast to the wealth of researchconducted on this compound, the anticancer effects of proteaseinhibitors isolated from other leguminous sources have receivedlimited attention. In the current study, 7 protease inhibitor concentrates(PICs) were isolated from various leguminous sources(including soybean) and characterized. The effects of PICs on theproliferation of breast and prostate cancer cells were investigatedin vitro. Chickpea PIC significantly inhibited the viability ofMDAMB-231 breast cancer and PC-3 and LNCaP prostate cancer cellsat all concentrations tested (25–400 μg/ml). In addition, kidneybean (200, 400 μg/ml), soybean (50, 100 μg/ml), and mungbean(100, 200 μg/ml) PICs inhibited LNCaP cell viability. These findingssuggest that leguminous PICs may possess similar anticancerproperties to that of soybean BBI and deserve further study aspossible chemopreventive agents.

U2 - 10.1080/01635581.2012.688914

DO - 10.1080/01635581.2012.688914

M3 - Article

VL - 1-8

JO - Nutrition and Cancer - An International Journal

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