Chemical cholecystokinin receptor activation protects against obesity-diabetes in high fat fed mice and has sustainable beneficial effects in genetic ob/ob mice.

Nigel Irwin; IA Montgomery; RC Moffett; Peter Flatt

doi:10.1016/j.bcp.2012.10.008

Chemical cholecystokinin receptor activation protects against obesity-diabetes in high fat fed mice and has sustainable beneficial effects in genetic ob/ob mice.

Nigel Irwin
, IA Montgomery
, RC Moffett
, Peter Flatt

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

The current study has determined the ability of (pGlu-Gln)-CCK-8 to counter the development of diet-induced obesity-diabetes and examined persistence of beneficial metabolic effects in high fat and ob/ob mice, respectively. Twice daily injection of (pGlu-Gln)-CCK-8 in normal mice transferred to a high fat diet reduced energy intake (p

Original language	English
Pages (from-to)	81-91
Journal	Biochemical Pharmacology
Volume	85
DOIs	https://doi.org/10.1016/j.bcp.2012.10.008
Publication status	Published (in print/issue) - 17 Oct 2012

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1016/j.bcp.2012.10.008

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title = "Chemical cholecystokinin receptor activation protects against obesity-diabetes in high fat fed mice and has sustainable beneficial effects in genetic ob/ob mice.",

abstract = "The current study has determined the ability of (pGlu-Gln)-CCK-8 to counter the development of diet-induced obesity-diabetes and examined persistence of beneficial metabolic effects in high fat and ob/ob mice, respectively. Twice daily injection of (pGlu-Gln)-CCK-8 in normal mice transferred to a high fat diet reduced energy intake (p",

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T1 - Chemical cholecystokinin receptor activation protects against obesity-diabetes in high fat fed mice and has sustainable beneficial effects in genetic ob/ob mice.

AU - Irwin, Nigel

AU - Montgomery, IA

AU - Moffett, RC

AU - Flatt, Peter

PY - 2012/10/17

Y1 - 2012/10/17

N2 - The current study has determined the ability of (pGlu-Gln)-CCK-8 to counter the development of diet-induced obesity-diabetes and examined persistence of beneficial metabolic effects in high fat and ob/ob mice, respectively. Twice daily injection of (pGlu-Gln)-CCK-8 in normal mice transferred to a high fat diet reduced energy intake (p

AB - The current study has determined the ability of (pGlu-Gln)-CCK-8 to counter the development of diet-induced obesity-diabetes and examined persistence of beneficial metabolic effects in high fat and ob/ob mice, respectively. Twice daily injection of (pGlu-Gln)-CCK-8 in normal mice transferred to a high fat diet reduced energy intake (p

U2 - 10.1016/j.bcp.2012.10.008

DO - 10.1016/j.bcp.2012.10.008

M3 - Article

VL - 85

SP - 81

EP - 91

JO - Biochemical Pharmacology

JF - Biochemical Pharmacology

ER -

Chemical cholecystokinin receptor activation protects against obesity-diabetes in high fat fed mice and has sustainable beneficial effects in genetic ob/ob mice.

Abstract

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