Chemical cholecystokinin receptor activation protects against obesity-diabetes in high fat fed mice and has sustainable beneficial effects in genetic ob/ob mice.

Nigel Irwin, IA Montgomery, RC Moffett, Peter Flatt

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The current study has determined the ability of (pGlu-Gln)-CCK-8 to counter the development of diet-induced obesity-diabetes and examined persistence of beneficial metabolic effects in high fat and ob/ob mice, respectively. Twice daily injection of (pGlu-Gln)-CCK-8 in normal mice transferred to a high fat diet reduced energy intake (p
Original languageEnglish
Pages (from-to)81-91
JournalBiochemical Pharmacology
Volume85
DOIs
Publication statusPublished - 17 Oct 2012

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