Chemical cholecystokinin receptor activation protects against obesity-diabetes in high fat fed mice and has sustainable beneficial effects in genetic ob/ob mice.

Nigel Irwin, IA Montgomery, RC Moffett, Peter Flatt

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Abstract

The current study has determined the ability of (pGlu-Gln)-CCK-8 to counter the development of diet-induced obesity-diabetes and examined persistence of beneficial metabolic effects in high fat and ob/ob mice, respectively. Twice daily injection of (pGlu-Gln)-CCK-8 in normal mice transferred to a high fat diet reduced energy intake (p
LanguageEnglish
Pages81-91
JournalBIiochemical Pharmacology
Volume85
DOIs
Publication statusPublished - 17 Oct 2012

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Cholecystokinin Receptors
Nutrition
Medical problems
Obesity
Chemical activation
Fats
High Fat Diet
Energy Intake
Diet
Injections
(pGlu-Gln)-CCK-8

Cite this

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abstract = "The current study has determined the ability of (pGlu-Gln)-CCK-8 to counter the development of diet-induced obesity-diabetes and examined persistence of beneficial metabolic effects in high fat and ob/ob mice, respectively. Twice daily injection of (pGlu-Gln)-CCK-8 in normal mice transferred to a high fat diet reduced energy intake (p",
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AU - Irwin, Nigel

AU - Montgomery, IA

AU - Moffett, RC

AU - Flatt, Peter

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