Characterizing changes in the excitability of corticospinal projections to proximal muscles of the upper limb

Richard G Carson, Barry D Nelson, Alison R Buick, Timothy J Carroll, Niamh C Kennedy, Rachel Mac Cann

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    There has been an explosion of interest in methods of exogenous brain stimulation that induce changes in the excitability of human cerebral cortex. The expectation is that these methods may promote recovery of function following brain injury. To assess their effects on motor output, it is typical to assess the state of corticospinal projections from primary motor cortex to muscles of the hand, via electromyographic responses to transcranial magnetic stimulation. If a range of stimulation intensities is employed, the recruitment curves (RCs) obtained can, at least for intrinsic hand muscles, be fitted by a sigmoid function.
    Original languageEnglish
    Pages (from-to)760-8
    JournalBrain Stimulation
    Issue number5
    Early online date24 Feb 2013
    Publication statusPublished - 1 Sep 2013



    • Motor evoked potentials
    • Goodness of fit
    • Plasticity
    • arm
    • Afferent stimulation

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