Characterisation of the biological activity of xenin-25 degradation fragment peptides

CA Martin, V Parthsarathy, V Pathak, Victor Gault, Peter Flatt, Nigel Irwin

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Xenin-25, a peptide co-secreted with the incretin hormone glucose-dependent insulinotropic polypeptide (GIP), possesses promising therapeutic actions for obesity-diabetes. However, native xenin-25 is rapidly degraded by serum enzymes to yield the truncated metabolites xenin 9-25, xenin 11-25, xenin 14-25 and xenin 18-25. The present study has examined the biological activities of these fragment peptides. In vitro studies using BRIN BD11 cells demonstrated that native xenin-25 and xenin 18-25 possessed significant (P
LanguageEnglish
Pages193-200
JournalJournal of Endrocrinology
Volume221
Issue number2
DOIs
Publication statusPublished - 22 Apr 2014

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Peptide Fragments
Incretins
Peptides
xenin 25
Obesity
Hormones
Glucose
Enzymes
Serum

Cite this

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Characterisation of the biological activity of xenin-25 degradation fragment peptides. / Martin, CA; Parthsarathy, V; Pathak, V; Gault, Victor; Flatt, Peter; Irwin, Nigel.

In: Journal of Endrocrinology, Vol. 221, No. 2, 22.04.2014, p. 193-200.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Characterisation of the biological activity of xenin-25 degradation fragment peptides

AU - Martin, CA

AU - Parthsarathy, V

AU - Pathak, V

AU - Gault, Victor

AU - Flatt, Peter

AU - Irwin, Nigel

PY - 2014/4/22

Y1 - 2014/4/22

N2 - Xenin-25, a peptide co-secreted with the incretin hormone glucose-dependent insulinotropic polypeptide (GIP), possesses promising therapeutic actions for obesity-diabetes. However, native xenin-25 is rapidly degraded by serum enzymes to yield the truncated metabolites xenin 9-25, xenin 11-25, xenin 14-25 and xenin 18-25. The present study has examined the biological activities of these fragment peptides. In vitro studies using BRIN BD11 cells demonstrated that native xenin-25 and xenin 18-25 possessed significant (P

AB - Xenin-25, a peptide co-secreted with the incretin hormone glucose-dependent insulinotropic polypeptide (GIP), possesses promising therapeutic actions for obesity-diabetes. However, native xenin-25 is rapidly degraded by serum enzymes to yield the truncated metabolites xenin 9-25, xenin 11-25, xenin 14-25 and xenin 18-25. The present study has examined the biological activities of these fragment peptides. In vitro studies using BRIN BD11 cells demonstrated that native xenin-25 and xenin 18-25 possessed significant (P

U2 - 10.1530/JOE-13-0617.R1

DO - 10.1530/JOE-13-0617.R1

M3 - Article

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SP - 193

EP - 200

JO - Journal of Endrocrinology

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