Characterisation of the biological activity of xenin-25 degradation fragment peptides

CA Martin; V Parthsarathy; V Pathak; Victor Gault; Peter Flatt; Nigel Irwin

doi:10.1530/JOE-13-0617.R1

Characterisation of the biological activity of xenin-25 degradation fragment peptides

CA Martin, V Parthsarathy, V Pathak, Victor Gault, Peter Flatt, Nigel Irwin

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

Xenin-25, a peptide co-secreted with the incretin hormone glucose-dependent insulinotropic polypeptide (GIP), possesses promising therapeutic actions for obesity-diabetes. However, native xenin-25 is rapidly degraded by serum enzymes to yield the truncated metabolites xenin 9-25, xenin 11-25, xenin 14-25 and xenin 18-25. The present study has examined the biological activities of these fragment peptides. In vitro studies using BRIN BD11 cells demonstrated that native xenin-25 and xenin 18-25 possessed significant (P

Original language	English
Pages (from-to)	193-200
Journal	Journal of Endrocrinology
Volume	221
Issue number	2
DOIs	https://doi.org/10.1530/JOE-13-0617.R1
Publication status	Published (in print/issue) - 22 Apr 2014

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AU - Martin, CA

AU - Parthsarathy, V

AU - Pathak, V

AU - Gault, Victor

AU - Flatt, Peter

AU - Irwin, Nigel

PY - 2014/4/22

Y1 - 2014/4/22

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AB - Xenin-25, a peptide co-secreted with the incretin hormone glucose-dependent insulinotropic polypeptide (GIP), possesses promising therapeutic actions for obesity-diabetes. However, native xenin-25 is rapidly degraded by serum enzymes to yield the truncated metabolites xenin 9-25, xenin 11-25, xenin 14-25 and xenin 18-25. The present study has examined the biological activities of these fragment peptides. In vitro studies using BRIN BD11 cells demonstrated that native xenin-25 and xenin 18-25 possessed significant (P

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DO - 10.1530/JOE-13-0617.R1

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JF - Journal of Endrocrinology

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Characterisation of the biological activity of xenin-25 degradation fragment peptides

Abstract

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