Characterisation of the biological activity of xenin-25 degradation fragment peptides

CA Martin, V Parthsarathy, V Pathak, Victor Gault, Peter Flatt, Nigel Irwin

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Xenin-25, a peptide co-secreted with the incretin hormone glucose-dependent insulinotropic polypeptide (GIP), possesses promising therapeutic actions for obesity-diabetes. However, native xenin-25 is rapidly degraded by serum enzymes to yield the truncated metabolites xenin 9-25, xenin 11-25, xenin 14-25 and xenin 18-25. The present study has examined the biological activities of these fragment peptides. In vitro studies using BRIN BD11 cells demonstrated that native xenin-25 and xenin 18-25 possessed significant (P
Original languageEnglish
Pages (from-to)193-200
JournalJournal of Endrocrinology
Volume221
Issue number2
DOIs
Publication statusPublished - 22 Apr 2014

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