Characterisation of structurally modified analogues of glucagon as potential glucagon receptor antagonists

Finbarr O'Harte, ZJ Franklin, EP Rafferty, Nigel Irwin

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Acute in vitro and in vivo biological activities of four novel structural analogues of glucagon were tested. desHis1Pro4-glucagon, desHis1Pro4Glu9-glucagon, desHis1Pro4Glu9Lys12FA-glucagon and desHis1Pro4Glu9Lys30FA-glucagon were stable to DPP-4 degradation and dose-dependently inhibited glucagon-mediated cAMP production (p
LanguageEnglish
Pages26-34
JournalMolecular and Cellular Endocrinology
Volume381
Issue number1-2
DOIs
Publication statusPublished - 5 Dec 2013

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Characterisation of structurally modified analogues of glucagon as potential glucagon receptor antagonists. / O'Harte, Finbarr; Franklin, ZJ; Rafferty, EP; Irwin, Nigel.

In: Molecular and Cellular Endocrinology, Vol. 381, No. 1-2, 05.12.2013, p. 26-34.

Research output: Contribution to journalArticle

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AU - Franklin, ZJ

AU - Rafferty, EP

AU - Irwin, Nigel

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AB - Acute in vitro and in vivo biological activities of four novel structural analogues of glucagon were tested. desHis1Pro4-glucagon, desHis1Pro4Glu9-glucagon, desHis1Pro4Glu9Lys12FA-glucagon and desHis1Pro4Glu9Lys30FA-glucagon were stable to DPP-4 degradation and dose-dependently inhibited glucagon-mediated cAMP production (p

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