TY - JOUR
T1 - Characterisation of structurally modified analogues of glucagon as potential glucagon receptor antagonists
AU - O'Harte, Finbarr
AU - Franklin, ZJ
AU - Rafferty, EP
AU - Irwin, Nigel
PY - 2013/12/5
Y1 - 2013/12/5
N2 - Acute in vitro and in vivo biological activities of four novel structural analogues of glucagon were tested. desHis1Pro4-glucagon, desHis1Pro4Glu9-glucagon, desHis1Pro4Glu9Lys12FA-glucagon and desHis1Pro4Glu9Lys30FA-glucagon were stable to DPP-4 degradation and dose-dependently inhibited glucagon-mediated cAMP production (p
AB - Acute in vitro and in vivo biological activities of four novel structural analogues of glucagon were tested. desHis1Pro4-glucagon, desHis1Pro4Glu9-glucagon, desHis1Pro4Glu9Lys12FA-glucagon and desHis1Pro4Glu9Lys30FA-glucagon were stable to DPP-4 degradation and dose-dependently inhibited glucagon-mediated cAMP production (p
U2 - 10.1016/j.mce.2013.07.014
DO - 10.1016/j.mce.2013.07.014
M3 - Article
VL - 381
SP - 26
EP - 34
JO - Molecular and Cellular Endocrinology
JF - Molecular and Cellular Endocrinology
IS - 1-2
ER -