Characterisation of structurally modified analogues of glucagon as potential glucagon receptor antagonists

Finbarr O'Harte; ZJ Franklin; EP Rafferty; Nigel Irwin

doi:10.1016/j.mce.2013.07.014

Characterisation of structurally modified analogues of glucagon as potential glucagon receptor antagonists

Finbarr O'Harte, ZJ Franklin, EP Rafferty, Nigel Irwin

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

Acute in vitro and in vivo biological activities of four novel structural analogues of glucagon were tested. desHis1Pro4-glucagon, desHis1Pro4Glu9-glucagon, desHis1Pro4Glu9Lys12FA-glucagon and desHis1Pro4Glu9Lys30FA-glucagon were stable to DPP-4 degradation and dose-dependently inhibited glucagon-mediated cAMP production (p

Original language	English
Pages (from-to)	26-34
Journal	Molecular and Cellular Endocrinology
Volume	381
Issue number	1-2
DOIs	https://doi.org/10.1016/j.mce.2013.07.014
Publication status	Published (in print/issue) - 5 Dec 2013

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abstract = "Acute in vitro and in vivo biological activities of four novel structural analogues of glucagon were tested. desHis1Pro4-glucagon, desHis1Pro4Glu9-glucagon, desHis1Pro4Glu9Lys12FA-glucagon and desHis1Pro4Glu9Lys30FA-glucagon were stable to DPP-4 degradation and dose-dependently inhibited glucagon-mediated cAMP production (p",

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AU - O'Harte, Finbarr

AU - Franklin, ZJ

AU - Rafferty, EP

AU - Irwin, Nigel

PY - 2013/12/5

Y1 - 2013/12/5

N2 - Acute in vitro and in vivo biological activities of four novel structural analogues of glucagon were tested. desHis1Pro4-glucagon, desHis1Pro4Glu9-glucagon, desHis1Pro4Glu9Lys12FA-glucagon and desHis1Pro4Glu9Lys30FA-glucagon were stable to DPP-4 degradation and dose-dependently inhibited glucagon-mediated cAMP production (p

AB - Acute in vitro and in vivo biological activities of four novel structural analogues of glucagon were tested. desHis1Pro4-glucagon, desHis1Pro4Glu9-glucagon, desHis1Pro4Glu9Lys12FA-glucagon and desHis1Pro4Glu9Lys30FA-glucagon were stable to DPP-4 degradation and dose-dependently inhibited glucagon-mediated cAMP production (p

U2 - 10.1016/j.mce.2013.07.014

DO - 10.1016/j.mce.2013.07.014

M3 - Article

VL - 381

SP - 26

EP - 34

JO - Molecular and Cellular Endocrinology

JF - Molecular and Cellular Endocrinology

SN - 0303-7207

IS - 1-2

ER -

Characterisation of structurally modified analogues of glucagon as potential glucagon receptor antagonists

Abstract

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