Changes in Menopausal Risk Factors in Early Postmenopausal Osteopenic Women After 13 Months of High-Intensity Exercise: The Randomized Controlled ACTLIFE-RCT.

M Hettchen; S von Stengel; M Kohl; Marie H Murphy; M Shojaa; M Ghasemikaram; L Bragonzoni; F Benvenuti; C Ripamonti; MG Benedetti; M Julin; T Risto; W Kemmler

doi:10.2147/CIA.S283177

Changes in Menopausal Risk Factors in Early Postmenopausal Osteopenic Women After 13 Months of High-Intensity Exercise: The Randomized Controlled ACTLIFE-RCT.

M Hettchen, S von Stengel, M Kohl, Marie H Murphy, M Shojaa, M Ghasemikaram, L Bragonzoni, F Benvenuti, C Ripamonti , MG Benedetti , M Julin, T Risto, W Kemmler

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Abstract

The menopausal transition is a critical period in women’s lives. Exercise might be the most promising non-pharmaceutic intervention to address the large variety of risk factors related to the pronounced estradiol decline during peri- and early-postmenopause. The aim of this study was to determine the effect of an 18-month multipurpose exercise program on risk factors and symptoms related to the menopausal transition. Fifty-four women 1– 5 years postmenopause with osteopenia or osteoporosis were randomly assigned 1) to a high impact weight-bearing/high-intensity/velocity resistance training group (EG: n=27) exercising three times a week or 2) to an attendance control group (CG: n=27) that performed low-intensity exercise once a week. Both groups were supplemented with cholecalciferol and calcium. The primary study endpoint was bone mineral density (BMD) at lumbar spine (LS) and total hip, secondary outcomes were lean body mass (LBM), total and abdominal body percentage, metabolic syndrome Z-Score (MetS-Z), menopausal symptoms and muscle strength and power. Due to COVID-19, the study was stopped after 13 months. We observed significant effects for BMD-LS (EG: 0.002± .018 versus CG: − .009± 0.018 mg/cm2, p=0.027) but not for BMD total hip (EG: − 0.01± .016 versus CG: − .009± 0.020 mg/cm2, p=0.129). LBM improved significantly in the EG and decreased in the CG (0.39± 1.08 vs − 0.37± 1.34 kg, p=0.026). Total and abdominal body fat improved significantly in the EG and was maintained in the CG (− 1.44± 1.49 vs − 0.02± 1.55 kg, p=0.002 and -1.50± 2.33 vs 0.08± 2.07 kg, p=0.011). Significant effects in favor of the EG were also determined for menopausal symptoms (p=0.029), hip/leg extension strength (p< 0.001) and power (p< 0.001). However, changes of the MetS-Z did not differ significantly (p=0.149) between EG and CG. In summary, with minor exceptions, we demonstrated the effectiveness of a multipurpose exercise protocol dedicated to early-postmenopausal women on various risk factors and complaints related to the menopausal transition.

Original language	English
Pages (from-to)	83-96
Number of pages	14
Journal	Clinical Interventions in Aging
Volume	16
DOIs	https://doi.org/10.2147/CIA.S283177
Publication status	Published (in print/issue) - 11 Jan 2021

Bibliographical note

Funding Information:
This study is one of the intellectual outputs of the project “ACTLIFE-Physical activity the tool to improve the quality of life in osteoporosis people” and had grant support from the European Union’ s Erasmus Plus Sport program under grant agreement No. 2017-2128/001-001. W e further acknowledge support by Deutsche Forschungsgemeinschaft and Friedrich-Alexander-University Erlangen-Nürnberg within the funding program “Open Access Publishing”. However , the funding sources had no role in the design of this study nor its execution, analyses, interpretation of the data, or decision to submit results.

Publisher Copyright:
© 2021 Hettchen et al.

Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.

Keywords

Bone mineral density
Early postmenopause
Multipurpose exercise
Bone Density
Lumbar Vertebrae/diagnostic imaging
Risk Reduction Behavior
Humans
Middle Aged
Risk Factors
Bone Diseases, Metabolic/diagnosis
Osteoporosis, Postmenopausal/diagnosis
Bone Density Conservation Agents/therapeutic use
Metabolic Syndrome/prevention & control
COVID-19/epidemiology
Postmenopause
Female
Outcome Assessment, Health Care
High-Intensity Interval Training/methods

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2147/CIA.S283177Licence: CC BY-NC

Final published articleFinal published version, 922 KBLicence: CC BY-NC

Cite this

Hettchen, M., von Stengel, S., Kohl, M., Murphy, M. H., Shojaa, M., Ghasemikaram, M., Bragonzoni, L., Benvenuti, F., Ripamonti , C., Benedetti , MG., Julin, M., Risto, T., & Kemmler, W. (2021). Changes in Menopausal Risk Factors in Early Postmenopausal Osteopenic Women After 13 Months of High-Intensity Exercise: The Randomized Controlled ACTLIFE-RCT. Clinical Interventions in Aging, 16, 83-96. https://doi.org/10.2147/CIA.S283177

@article{0b8130b0c6a14854bf4c71f4d455ce3b,

title = "Changes in Menopausal Risk Factors in Early Postmenopausal Osteopenic Women After 13 Months of High-Intensity Exercise: The Randomized Controlled ACTLIFE-RCT.",

abstract = "The menopausal transition is a critical period in women{\textquoteright}s lives. Exercise might be the most promising non-pharmaceutic intervention to address the large variety of risk factors related to the pronounced estradiol decline during peri- and early-postmenopause. The aim of this study was to determine the effect of an 18-month multipurpose exercise program on risk factors and symptoms related to the menopausal transition. Fifty-four women 1– 5 years postmenopause with osteopenia or osteoporosis were randomly assigned 1) to a high impact weight-bearing/high-intensity/velocity resistance training group (EG: n=27) exercising three times a week or 2) to an attendance control group (CG: n=27) that performed low-intensity exercise once a week. Both groups were supplemented with cholecalciferol and calcium. The primary study endpoint was bone mineral density (BMD) at lumbar spine (LS) and total hip, secondary outcomes were lean body mass (LBM), total and abdominal body percentage, metabolic syndrome Z-Score (MetS-Z), menopausal symptoms and muscle strength and power. Due to COVID-19, the study was stopped after 13 months. We observed significant effects for BMD-LS (EG: 0.002± .018 versus CG: − .009± 0.018 mg/cm2, p=0.027) but not for BMD total hip (EG: − 0.01± .016 versus CG: − .009± 0.020 mg/cm2, p=0.129). LBM improved significantly in the EG and decreased in the CG (0.39± 1.08 vs − 0.37± 1.34 kg, p=0.026). Total and abdominal body fat improved significantly in the EG and was maintained in the CG (− 1.44± 1.49 vs − 0.02± 1.55 kg, p=0.002 and -1.50± 2.33 vs 0.08± 2.07 kg, p=0.011). Significant effects in favor of the EG were also determined for menopausal symptoms (p=0.029), hip/leg extension strength (p< 0.001) and power (p< 0.001). However, changes of the MetS-Z did not differ significantly (p=0.149) between EG and CG. In summary, with minor exceptions, we demonstrated the effectiveness of a multipurpose exercise protocol dedicated to early-postmenopausal women on various risk factors and complaints related to the menopausal transition.",

keywords = "Bone mineral density, Early postmenopause, Multipurpose exercise, Bone Density, Lumbar Vertebrae/diagnostic imaging, Risk Reduction Behavior, Humans, Middle Aged, Risk Factors, Bone Diseases, Metabolic/diagnosis, Osteoporosis, Postmenopausal/diagnosis, Bone Density Conservation Agents/therapeutic use, Metabolic Syndrome/prevention & control, COVID-19/epidemiology, Postmenopause, Female, Outcome Assessment, Health Care, High-Intensity Interval Training/methods",

author = "M Hettchen and {von Stengel}, S and M Kohl and Murphy, {Marie H} and M Shojaa and M Ghasemikaram and L Bragonzoni and F Benvenuti and C Ripamonti and MG Benedetti and M Julin and T Risto and W Kemmler",

note = "Funding Information: This study is one of the intellectual outputs of the project “ACTLIFE-Physical activity the tool to improve the quality of life in osteoporosis people” and had grant support from the European Union{\textquoteright} s Erasmus Plus Sport program under grant agreement No. 2017-2128/001-001. W e further acknowledge support by Deutsche Forschungsgemeinschaft and Friedrich-Alexander-University Erlangen-N{\"u}rnberg within the funding program “Open Access Publishing”. However , the funding sources had no role in the design of this study nor its execution, analyses, interpretation of the data, or decision to submit results. Publisher Copyright: {\textcopyright} 2021 Hettchen et al. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",

year = "2021",

month = jan,

day = "11",

doi = "10.2147/CIA.S283177",

language = "English",

volume = "16",

pages = "83--96",

journal = "Clinical Interventions in Aging",

issn = "1176-9092",

publisher = "Dove Medical Press",

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Hettchen, M, von Stengel, S, Kohl, M, Murphy, MH, Shojaa, M, Ghasemikaram, M, Bragonzoni, L, Benvenuti, F, Ripamonti , C, Benedetti , MG, Julin, M, Risto, T & Kemmler, W 2021, 'Changes in Menopausal Risk Factors in Early Postmenopausal Osteopenic Women After 13 Months of High-Intensity Exercise: The Randomized Controlled ACTLIFE-RCT.', Clinical Interventions in Aging, vol. 16, pp. 83-96. https://doi.org/10.2147/CIA.S283177

TY - JOUR

T1 - Changes in Menopausal Risk Factors in Early Postmenopausal Osteopenic Women After 13 Months of High-Intensity Exercise: The Randomized Controlled ACTLIFE-RCT.

AU - Hettchen, M

AU - von Stengel, S

AU - Kohl, M

AU - Murphy, Marie H

AU - Shojaa, M

AU - Ghasemikaram, M

AU - Bragonzoni, L

AU - Benvenuti, F

AU - Ripamonti , C

AU - Benedetti , MG

AU - Julin, M

AU - Risto, T

AU - Kemmler, W

N1 - Funding Information: This study is one of the intellectual outputs of the project “ACTLIFE-Physical activity the tool to improve the quality of life in osteoporosis people” and had grant support from the European Union’ s Erasmus Plus Sport program under grant agreement No. 2017-2128/001-001. W e further acknowledge support by Deutsche Forschungsgemeinschaft and Friedrich-Alexander-University Erlangen-Nürnberg within the funding program “Open Access Publishing”. However , the funding sources had no role in the design of this study nor its execution, analyses, interpretation of the data, or decision to submit results. Publisher Copyright: © 2021 Hettchen et al. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/1/11

Y1 - 2021/1/11

N2 - The menopausal transition is a critical period in women’s lives. Exercise might be the most promising non-pharmaceutic intervention to address the large variety of risk factors related to the pronounced estradiol decline during peri- and early-postmenopause. The aim of this study was to determine the effect of an 18-month multipurpose exercise program on risk factors and symptoms related to the menopausal transition. Fifty-four women 1– 5 years postmenopause with osteopenia or osteoporosis were randomly assigned 1) to a high impact weight-bearing/high-intensity/velocity resistance training group (EG: n=27) exercising three times a week or 2) to an attendance control group (CG: n=27) that performed low-intensity exercise once a week. Both groups were supplemented with cholecalciferol and calcium. The primary study endpoint was bone mineral density (BMD) at lumbar spine (LS) and total hip, secondary outcomes were lean body mass (LBM), total and abdominal body percentage, metabolic syndrome Z-Score (MetS-Z), menopausal symptoms and muscle strength and power. Due to COVID-19, the study was stopped after 13 months. We observed significant effects for BMD-LS (EG: 0.002± .018 versus CG: − .009± 0.018 mg/cm2, p=0.027) but not for BMD total hip (EG: − 0.01± .016 versus CG: − .009± 0.020 mg/cm2, p=0.129). LBM improved significantly in the EG and decreased in the CG (0.39± 1.08 vs − 0.37± 1.34 kg, p=0.026). Total and abdominal body fat improved significantly in the EG and was maintained in the CG (− 1.44± 1.49 vs − 0.02± 1.55 kg, p=0.002 and -1.50± 2.33 vs 0.08± 2.07 kg, p=0.011). Significant effects in favor of the EG were also determined for menopausal symptoms (p=0.029), hip/leg extension strength (p< 0.001) and power (p< 0.001). However, changes of the MetS-Z did not differ significantly (p=0.149) between EG and CG. In summary, with minor exceptions, we demonstrated the effectiveness of a multipurpose exercise protocol dedicated to early-postmenopausal women on various risk factors and complaints related to the menopausal transition.

AB - The menopausal transition is a critical period in women’s lives. Exercise might be the most promising non-pharmaceutic intervention to address the large variety of risk factors related to the pronounced estradiol decline during peri- and early-postmenopause. The aim of this study was to determine the effect of an 18-month multipurpose exercise program on risk factors and symptoms related to the menopausal transition. Fifty-four women 1– 5 years postmenopause with osteopenia or osteoporosis were randomly assigned 1) to a high impact weight-bearing/high-intensity/velocity resistance training group (EG: n=27) exercising three times a week or 2) to an attendance control group (CG: n=27) that performed low-intensity exercise once a week. Both groups were supplemented with cholecalciferol and calcium. The primary study endpoint was bone mineral density (BMD) at lumbar spine (LS) and total hip, secondary outcomes were lean body mass (LBM), total and abdominal body percentage, metabolic syndrome Z-Score (MetS-Z), menopausal symptoms and muscle strength and power. Due to COVID-19, the study was stopped after 13 months. We observed significant effects for BMD-LS (EG: 0.002± .018 versus CG: − .009± 0.018 mg/cm2, p=0.027) but not for BMD total hip (EG: − 0.01± .016 versus CG: − .009± 0.020 mg/cm2, p=0.129). LBM improved significantly in the EG and decreased in the CG (0.39± 1.08 vs − 0.37± 1.34 kg, p=0.026). Total and abdominal body fat improved significantly in the EG and was maintained in the CG (− 1.44± 1.49 vs − 0.02± 1.55 kg, p=0.002 and -1.50± 2.33 vs 0.08± 2.07 kg, p=0.011). Significant effects in favor of the EG were also determined for menopausal symptoms (p=0.029), hip/leg extension strength (p< 0.001) and power (p< 0.001). However, changes of the MetS-Z did not differ significantly (p=0.149) between EG and CG. In summary, with minor exceptions, we demonstrated the effectiveness of a multipurpose exercise protocol dedicated to early-postmenopausal women on various risk factors and complaints related to the menopausal transition.

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KW - Early postmenopause

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KW - Risk Reduction Behavior

KW - Humans

KW - Middle Aged

KW - Risk Factors

KW - Bone Diseases, Metabolic/diagnosis

KW - Osteoporosis, Postmenopausal/diagnosis

KW - Bone Density Conservation Agents/therapeutic use

KW - Metabolic Syndrome/prevention & control

KW - COVID-19/epidemiology

KW - Postmenopause

KW - Female

KW - Outcome Assessment, Health Care

KW - High-Intensity Interval Training/methods

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U2 - 10.2147/CIA.S283177

DO - 10.2147/CIA.S283177

M3 - Article

C2 - 33469276

SN - 1176-9092

VL - 16

SP - 83

EP - 96

JO - Clinical Interventions in Aging

JF - Clinical Interventions in Aging

ER -

Changes in Menopausal Risk Factors in Early Postmenopausal Osteopenic Women After 13 Months of High-Intensity Exercise: The Randomized Controlled ACTLIFE-RCT.

Abstract

Bibliographical note

Keywords

UN SDGs

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