Challenges in stem cell-derived islet replacement therapy can be overcome

Midhat H. Abdulreda, Per-Olof Berggren

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Abstract

In this Commentary, we echo the conclusions of a recent review titled “The promise of stem cell-derived islet replacement therapy,” which highlighted recent advances in producing glucose responsive “islets” from stem cells and the benefits of their use in islet transplant therapy in type 1 diabetes (T1D). The review also outlined the status of clinical islet transplantation and the challenges that have prevented it from reaching its full therapeutic promise. We agree with the conclusions of the review and suggest that the identified challenges may be overcome by using the eye anterior chamber as an islet transplant site. We anticipate that the combination of stem cell-derived islets and intraocular transplant could help this promising T1D therapy reach full fruition.
Original languageEnglish
Pages (from-to)1-5
JournalCell Transplantation
Volume30
DOIs
Publication statusPublished - 27 Sep 2021

Keywords

  • stem cell-derived islets, glucose responsive, insulin insufficiency, insulin independence, diabetes, anterior chamber of the eye, intraocular transplantation, islet transplant, immune rejection, immune tolerance
  • glucose responsive
  • insulin insufficiency
  • insulin independence
  • diabetes
  • anterior chamber of the eye,
  • intraocular transplantation,
  • islet transplant
  • immune rejection
  • immune tolerance

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