TY - GEN
T1 - Central effects of trout tachykinins on heart rate variability in trout
AU - Lancien, Frédéric
AU - Mimassi, Nagi
AU - Conlon, John Michael
AU - Le Mével, Jean Claude
PY - 2009/4
Y1 - 2009/4
N2 - Recent studies in trout have shown that tachykinins might be selectively implicated in important neuroregulatory functions related to the central control of ventilation. In teleost fish, cardiorespiratory coupling probably contributes to heart rate variability (HRV), and the hypoventilatory effects observed after central injection of tachykinins suggest that these peptides also may produce changes in HRV. Consequently, the present study was undertaken to compare the central actions of picomolar doses (25-250 pmol) of trout neuropeptide gamma (NPγ), substance P (SP), and neurokinin A (NKA) on HRV in unanesthetized rainbow trout. Compared to vehicle-injected trout, Poincaré plot analysis of HRV demonstrated that intracerebroventricular injection of NPγ dose dependently increased HRV. SP evoked a significant elevation of HRV but only at the highest dose (250 pmol). In contrast, NKA was without any effect on HRV. In conclusion, these results suggest that NPγ may be selectively implicated in the central control of HRV in trout.
AB - Recent studies in trout have shown that tachykinins might be selectively implicated in important neuroregulatory functions related to the central control of ventilation. In teleost fish, cardiorespiratory coupling probably contributes to heart rate variability (HRV), and the hypoventilatory effects observed after central injection of tachykinins suggest that these peptides also may produce changes in HRV. Consequently, the present study was undertaken to compare the central actions of picomolar doses (25-250 pmol) of trout neuropeptide gamma (NPγ), substance P (SP), and neurokinin A (NKA) on HRV in unanesthetized rainbow trout. Compared to vehicle-injected trout, Poincaré plot analysis of HRV demonstrated that intracerebroventricular injection of NPγ dose dependently increased HRV. SP evoked a significant elevation of HRV but only at the highest dose (250 pmol). In contrast, NKA was without any effect on HRV. In conclusion, these results suggest that NPγ may be selectively implicated in the central control of HRV in trout.
KW - Heart rate variability
KW - Neurokinin A
KW - Neuropeptide γ
KW - Poincaré plot analysis
KW - Substance P
KW - Teleosts
UR - http://www.scopus.com/inward/record.url?scp=65449188307&partnerID=8YFLogxK
U2 - 10.1111/j.1749-6632.2009.04428.x
DO - 10.1111/j.1749-6632.2009.04428.x
M3 - Conference contribution
C2 - 19456365
AN - SCOPUS:65449188307
SN - 9781573316712
T3 - Annals of the New York Academy of Sciences
SP - 379
EP - 382
BT - Trends in Comparative Endocrinology and Neurobiology
ER -