Central and peripheral cardiovascular, ventilatory, and motor effects of trout urotensin-II in the trout

Jean Claude Le Mével; Frédéric Lancien; Nagi Mimassi; Jérôme Leprince; J. Michael Conlon; Hubert Vaudry

doi:10.1016/j.peptides.2007.06.020

Central and peripheral cardiovascular, ventilatory, and motor effects of trout urotensin-II in the trout

Jean Claude Le Mével
, Frédéric Lancien
, Nagi Mimassi
, Jérôme Leprince
, J. Michael Conlon
, Hubert Vaudry

School of Biomedical Sciences

INSERM

Research output: Contribution to journal › Review article › peer-review

25 Citations (Scopus)

Abstract

Urotensin-II (U-II) was originally considered to be exclusively the product of the caudal neurosecretory system (CNSS) of teleost fish, but it has now been demonstrated that U-II is widely expressed in peripheral tissues and nervous structures of species from lampreys to mammals. However, very little is known regarding the physiological effects of this peptide in its species of origin. In the present review, we summarize the most significant results relating to the cardiovascular, ventilatory, and motor effects of centrally and peripherally administered synthetic trout U-II in our experimental animal model, the unanesthetized trout Oncorhynchus mykiss. In addition, we compare the actions of U-II with those of other neurohormonal peptides, particularly with the actions of urotensin-I, a 41-amino acid residue peptide paralogous to corticotropin-releasing hormone that is co-localized with U-II within neurons of the CNSS.

Original language	English
Pages (from-to)	830-837
Number of pages	8
Journal	Peptides
Volume	29
Issue number	5
DOIs	https://doi.org/10.1016/j.peptides.2007.06.020
Publication status	Published (in print/issue) - May 2008

Funding

We thank Drs. Kenneth Olson, Daniel Conklin, David Waugh and David Smith for their help during cardiovascular in vitro and in vivo studies on trout U-II. We also would like to extend our special thanks to Dr. Mabin for his support of the research conducted throughout the years at the Faculty of Medicine in Brest where he headed the Laboratory of Neurophysiology. We are also grateful to Agnès Novella for her excellent technical assistance and care in the maintenance of the animals. This work was supported by grants from the Institut National de la Santé et de la Recherche Médicale (U650 and U413) and by the LARC-Neuroscience Network.

Funders	Funder number
Institut National de la Santé et de la Recherche Médicale, Paris, France	U413, U650

Keywords

Blood pressure
Brain
Heart rate
Intra-arterial injection
Intracerebroventricular injection
Locomotion
Neuropeptides
Ventilation

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10.1016/j.peptides.2007.06.020

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title = "Central and peripheral cardiovascular, ventilatory, and motor effects of trout urotensin-II in the trout",

abstract = "Urotensin-II (U-II) was originally considered to be exclusively the product of the caudal neurosecretory system (CNSS) of teleost fish, but it has now been demonstrated that U-II is widely expressed in peripheral tissues and nervous structures of species from lampreys to mammals. However, very little is known regarding the physiological effects of this peptide in its species of origin. In the present review, we summarize the most significant results relating to the cardiovascular, ventilatory, and motor effects of centrally and peripherally administered synthetic trout U-II in our experimental animal model, the unanesthetized trout Oncorhynchus mykiss. In addition, we compare the actions of U-II with those of other neurohormonal peptides, particularly with the actions of urotensin-I, a 41-amino acid residue peptide paralogous to corticotropin-releasing hormone that is co-localized with U-II within neurons of the CNSS.",

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author = "\{Le M{\'e}vel\}, \{Jean Claude\} and Fr{\'e}d{\'e}ric Lancien and Nagi Mimassi and J{\'e}r{\^o}me Leprince and Conlon, \{J. Michael\} and Hubert Vaudry",

year = "2008",

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doi = "10.1016/j.peptides.2007.06.020",

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T1 - Central and peripheral cardiovascular, ventilatory, and motor effects of trout urotensin-II in the trout

AU - Le Mével, Jean Claude

AU - Lancien, Frédéric

AU - Mimassi, Nagi

AU - Leprince, Jérôme

AU - Conlon, J. Michael

AU - Vaudry, Hubert

PY - 2008/5

Y1 - 2008/5

N2 - Urotensin-II (U-II) was originally considered to be exclusively the product of the caudal neurosecretory system (CNSS) of teleost fish, but it has now been demonstrated that U-II is widely expressed in peripheral tissues and nervous structures of species from lampreys to mammals. However, very little is known regarding the physiological effects of this peptide in its species of origin. In the present review, we summarize the most significant results relating to the cardiovascular, ventilatory, and motor effects of centrally and peripherally administered synthetic trout U-II in our experimental animal model, the unanesthetized trout Oncorhynchus mykiss. In addition, we compare the actions of U-II with those of other neurohormonal peptides, particularly with the actions of urotensin-I, a 41-amino acid residue peptide paralogous to corticotropin-releasing hormone that is co-localized with U-II within neurons of the CNSS.

AB - Urotensin-II (U-II) was originally considered to be exclusively the product of the caudal neurosecretory system (CNSS) of teleost fish, but it has now been demonstrated that U-II is widely expressed in peripheral tissues and nervous structures of species from lampreys to mammals. However, very little is known regarding the physiological effects of this peptide in its species of origin. In the present review, we summarize the most significant results relating to the cardiovascular, ventilatory, and motor effects of centrally and peripherally administered synthetic trout U-II in our experimental animal model, the unanesthetized trout Oncorhynchus mykiss. In addition, we compare the actions of U-II with those of other neurohormonal peptides, particularly with the actions of urotensin-I, a 41-amino acid residue peptide paralogous to corticotropin-releasing hormone that is co-localized with U-II within neurons of the CNSS.

KW - Blood pressure

KW - Brain

KW - Heart rate

KW - Intra-arterial injection

KW - Intracerebroventricular injection

KW - Locomotion

KW - Neuropeptides

KW - Ventilation

UR - https://www.scopus.com/pages/publications/42149083241

U2 - 10.1016/j.peptides.2007.06.020

DO - 10.1016/j.peptides.2007.06.020

M3 - Review article

C2 - 17681644

AN - SCOPUS:42149083241

SN - 0196-9781

VL - 29

SP - 830

EP - 837

JO - Peptides

JF - Peptides

IS - 5

ER -

Central and peripheral cardiovascular, ventilatory, and motor effects of trout urotensin-II in the trout

Abstract

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Keywords

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