Cellular signalling pathways mediating the pathogenesis of chronic inflammatory respiratory diseases: an update

Meenu Mehta, Daljeet S. Dhanjal, Keshav R. Paudel, Bhupender Singh, Gaurav Gupta, S. Rajeshkumar, Lakshmi Thangavelu, Murtaza M. Tambuwala, Hamid A. Bakshi, Dinesh K. Chellappan, Parijat Pandey, Harish Dureja, Nitin B. Charbe, Sachin K. Singh, Shakti D. Shukla, Srinivas Nammi, Alaa A. Aljabali, Peter R. Wich, Philip M. Hansbro, Saurabh SatijaKamal Dua

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Respiratory disorders, especially non-communicable, chronic inflammatory diseases, are amongst the leading causes of mortality and morbidity worldwide. Respiratory diseases involve multiple pulmonary components, including airways and lungs that lead to their abnormal physiological functioning. Several signaling pathways have been reported to play an important role in the pathophysiology of respiratory diseases. These pathways, in addition, become the compounding factors contributing to the clinical outcomes in respiratory diseases. A range of signaling components such as Notch, Hedgehog, Wingless/Wnt, bone morphogenetic proteins, epidermal growth factor and fibroblast growth factor is primarily employed by these pathways in the eventual cascade of events. The different aberrations in such cell-signaling processes trigger the onset of respiratory diseases making the conventional therapeutic modalities ineffective. These challenges have prompted us to explore novel and effective approaches for the prevention and/or treatment of respiratory diseases. In this review, we have attempted to deliberate on the current literature describing the role of major cell signaling pathways in the pathogenesis of pulmonary diseases and discuss promising advances in the field of therapeutics that could lead to novel clinical therapies capable of preventing or reversing pulmonary vascular pathology in such patients.
Original languageEnglish
Pages (from-to)795-817
Number of pages23
JournalInflammopharmacology
Volume28
Issue number4
Early online date18 Mar 2020
DOIs
Publication statusPublished - 1 Aug 2020

Keywords

  • Cell signaling
  • Inflammatory
  • Respiratory diseases
  • Wnt pathway

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    Mehta, M., Dhanjal, D. S., Paudel, K. R., Singh, B., Gupta, G., Rajeshkumar, S., Thangavelu, L., Tambuwala, M. M., Bakshi, H. A., Chellappan, D. K., Pandey, P., Dureja, H., Charbe, N. B., Singh, S. K., Shukla, S. D., Nammi, S., Aljabali, A. A., Wich, P. R., Hansbro, P. M., ... Dua, K. (2020). Cellular signalling pathways mediating the pathogenesis of chronic inflammatory respiratory diseases: an update. Inflammopharmacology, 28(4), 795-817. https://doi.org/10.1007/s10787-020-00698-3