Cell biology at the interface of nanobiosensors and microfluidics

Nikhil Bhalla, Hung Ju Chiang, Amy Q. Shen

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

It is at the nanometer scale where biology, chemistry, and material science converge. With recent progresses in nanotechnology, research in cell biology has gained enormous interest from a growing multidisciplinary community of scientists in academia and industry. Many efforts have been made to discover cures for diseases through advancements in nanobiosensors and microfluidics. In this chapter, we give a general introduction to nanobiosensors and microfluidics technology, present key developments in the field, and illustrate the breadth of microfluidics-based sensing strategies available for cell biology. We also provide protocols for fabricating localized surface plasmon resonance (LSPR)-based nanobiosensors, and for integration of LSPR with a microfluidic device. Finally, we highlight applications and challenges associated with the use of nanobiosensing and microfluidics technology. This chapter should provide a solid platform for cell biologists to develop simple microfluidic LSPR chips for routine cell-based assays.

LanguageEnglish
Title of host publicationMethods in Cell Biology
EditorsDaniel A. Fletcher, Junsang Doh, Matthieu Piel
Pages203-227
Number of pages25
DOIs
Publication statusPublished - 15 Nov 2018

Publication series

NameMethods in Cell Biology
Volume148
ISSN (Print)0091-679X

Fingerprint

Microfluidics
Cell Biology
Surface Plasmon Resonance
Lab-On-A-Chip Devices
Technology
Nanotechnology
Industry
Research

Keywords

  • Bioassays
  • Biosensors
  • Cell biology
  • LSPR
  • Microfluidics
  • Nanoplasmonics

Cite this

Bhalla, N., Chiang, H. J., & Shen, A. Q. (2018). Cell biology at the interface of nanobiosensors and microfluidics. In D. A. Fletcher, J. Doh, & M. Piel (Eds.), Methods in Cell Biology (pp. 203-227). (Methods in Cell Biology; Vol. 148). https://doi.org/10.1016/bs.mcb.2018.09.009
Bhalla, Nikhil ; Chiang, Hung Ju ; Shen, Amy Q. / Cell biology at the interface of nanobiosensors and microfluidics. Methods in Cell Biology. editor / Daniel A. Fletcher ; Junsang Doh ; Matthieu Piel. 2018. pp. 203-227 (Methods in Cell Biology).
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Bhalla, N, Chiang, HJ & Shen, AQ 2018, Cell biology at the interface of nanobiosensors and microfluidics. in DA Fletcher, J Doh & M Piel (eds), Methods in Cell Biology. Methods in Cell Biology, vol. 148, pp. 203-227. https://doi.org/10.1016/bs.mcb.2018.09.009

Cell biology at the interface of nanobiosensors and microfluidics. / Bhalla, Nikhil; Chiang, Hung Ju; Shen, Amy Q.

Methods in Cell Biology. ed. / Daniel A. Fletcher; Junsang Doh; Matthieu Piel. 2018. p. 203-227 (Methods in Cell Biology; Vol. 148).

Research output: Chapter in Book/Report/Conference proceedingChapter

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Bhalla N, Chiang HJ, Shen AQ. Cell biology at the interface of nanobiosensors and microfluidics. In Fletcher DA, Doh J, Piel M, editors, Methods in Cell Biology. 2018. p. 203-227. (Methods in Cell Biology). https://doi.org/10.1016/bs.mcb.2018.09.009