Cardiovascular actions of the stress-related neurohormonal peptides, corticotropin-releasing factor and urotensin-I in the trout Oncorhynchus mykiss

Jean Claude Le Mével; Nagi Mimassi; Frédéric Lancien; Dominique Mabin; J. Michael Conlon

doi:10.1016/j.ygcen.2005.11.007

Cardiovascular actions of the stress-related neurohormonal peptides, corticotropin-releasing factor and urotensin-I in the trout Oncorhynchus mykiss

Jean Claude Le Mével
, Nagi Mimassi
, Frédéric Lancien
, Dominique Mabin
, J. Michael Conlon

School of Biomedical Sciences

Universite de Bretagne Occidentale

Research output: Contribution to journal › Review article › peer-review

16 Citations (Scopus)

Abstract

In this review, we summarize the most significant data concerning the cardiovascular effects of centrally and peripherally administered synthetic trout corticotropin-releasing factor (CRF) and urotensin-I (U-I) in our animal model, the unanesthetized trout Oncorhynchus mykiss. Although there is more than 60% sequence identity between these two stress-related neurohormonal peptides, CRF and U-I-induced differential actions upon the mean dorsal aortic blood pressure (Pda) and the heart rate (HR) in trout maintained under similar experimental situations. After intracerebroventricular injections, only U-I induced an increase in Pda while in non-cannulated trout, CRF only decreased the HR and elevated the heart rate variability by a presumed activation of the parasympathetic nervous system activity to the heart. The CRF antagonist, the α-helical CRF_9-41 blocked these central actions of CRF. After intra-arterial (IA) injections, U-I induced a direct hypotensive action and an elevation in HR. This hypotensive phase was reversed to hypertension by the release of catecholamines. IA injection of CRF caused no change in Pda or HR. These cardiovascular effects are compared with the much better established actions of CRF and the orthologous urocortins in mammals.

Original language	English
Pages (from-to)	56-61
Number of pages	6
Journal	General and Comparative Endocrinology
Volume	146
Issue number	1
DOIs	https://doi.org/10.1016/j.ygcen.2005.11.007
Publication status	Published (in print/issue) - Mar 2006

Funding

We thank Drs. Jörgen Jensen et Fatemeh Shahbazi (Department of Zoophysiology, Göteborg University, SE 40530 Göteborg, Sweden) for the study of U-I on isolated vessels and Dr. Catherine Delarue (Laboratory of Cellular and Molecular Endocrinology, INSERM U413, University of Rouen, France) for measuring plasma cortisol levels. We also thank Agnès Novella for her technical assistance and care in the maintenance of the animals. The research on trout CRF and U-I reported in this review was supported by grants from INSERM U650 and by the North Atlantic Treaty Organization Collaborative Research Grant (CRG.CRG972998). This review paper was based on a presentation in a symposium at the 15th International Congress of Comparative Endocrinology in Boston, MA, May 23–28, 2005. We thank Drs. Nick Bernier and Robert Denver for organizing the symposium.

Funders	Funder number
CRG.CRG972998
Institut National de la Santé et de la Recherche Médicale, Paris, France	U650

Keywords

Blood pressure
Brain
Catecholamines
CRF
Heart rate
Heart rate variability
Peripheral circulation
Stress
Trout
Urotensin-I

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10.1016/j.ygcen.2005.11.007

Cite this

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title = "Cardiovascular actions of the stress-related neurohormonal peptides, corticotropin-releasing factor and urotensin-I in the trout Oncorhynchus mykiss",

abstract = "In this review, we summarize the most significant data concerning the cardiovascular effects of centrally and peripherally administered synthetic trout corticotropin-releasing factor (CRF) and urotensin-I (U-I) in our animal model, the unanesthetized trout Oncorhynchus mykiss. Although there is more than 60\% sequence identity between these two stress-related neurohormonal peptides, CRF and U-I-induced differential actions upon the mean dorsal aortic blood pressure (Pda) and the heart rate (HR) in trout maintained under similar experimental situations. After intracerebroventricular injections, only U-I induced an increase in Pda while in non-cannulated trout, CRF only decreased the HR and elevated the heart rate variability by a presumed activation of the parasympathetic nervous system activity to the heart. The CRF antagonist, the α-helical CRF9-41 blocked these central actions of CRF. After intra-arterial (IA) injections, U-I induced a direct hypotensive action and an elevation in HR. This hypotensive phase was reversed to hypertension by the release of catecholamines. IA injection of CRF caused no change in Pda or HR. These cardiovascular effects are compared with the much better established actions of CRF and the orthologous urocortins in mammals.",

keywords = "Blood pressure, Brain, Catecholamines, CRF, Heart rate, Heart rate variability, Peripheral circulation, Stress, Trout, Urotensin-I",

author = "\{Le M{\'e}vel\}, \{Jean Claude\} and Nagi Mimassi and Fr{\'e}d{\'e}ric Lancien and Dominique Mabin and Conlon, \{J. Michael\}",

year = "2006",

month = mar,

doi = "10.1016/j.ygcen.2005.11.007",

language = "English",

volume = "146",

pages = "56--61",

journal = "General and Comparative Endocrinology",

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Cardiovascular actions of the stress-related neurohormonal peptides, corticotropin-releasing factor and urotensin-I in the trout Oncorhynchus mykiss. / Le Mével, Jean Claude; Mimassi, Nagi; Lancien, Frédéric et al.
In: General and Comparative Endocrinology, Vol. 146, No. 1, 03.2006, p. 56-61.

Research output: Contribution to journal › Review article › peer-review

TY - JOUR

T1 - Cardiovascular actions of the stress-related neurohormonal peptides, corticotropin-releasing factor and urotensin-I in the trout Oncorhynchus mykiss

AU - Le Mével, Jean Claude

AU - Mimassi, Nagi

AU - Lancien, Frédéric

AU - Mabin, Dominique

AU - Conlon, J. Michael

PY - 2006/3

Y1 - 2006/3

N2 - In this review, we summarize the most significant data concerning the cardiovascular effects of centrally and peripherally administered synthetic trout corticotropin-releasing factor (CRF) and urotensin-I (U-I) in our animal model, the unanesthetized trout Oncorhynchus mykiss. Although there is more than 60% sequence identity between these two stress-related neurohormonal peptides, CRF and U-I-induced differential actions upon the mean dorsal aortic blood pressure (Pda) and the heart rate (HR) in trout maintained under similar experimental situations. After intracerebroventricular injections, only U-I induced an increase in Pda while in non-cannulated trout, CRF only decreased the HR and elevated the heart rate variability by a presumed activation of the parasympathetic nervous system activity to the heart. The CRF antagonist, the α-helical CRF9-41 blocked these central actions of CRF. After intra-arterial (IA) injections, U-I induced a direct hypotensive action and an elevation in HR. This hypotensive phase was reversed to hypertension by the release of catecholamines. IA injection of CRF caused no change in Pda or HR. These cardiovascular effects are compared with the much better established actions of CRF and the orthologous urocortins in mammals.

AB - In this review, we summarize the most significant data concerning the cardiovascular effects of centrally and peripherally administered synthetic trout corticotropin-releasing factor (CRF) and urotensin-I (U-I) in our animal model, the unanesthetized trout Oncorhynchus mykiss. Although there is more than 60% sequence identity between these two stress-related neurohormonal peptides, CRF and U-I-induced differential actions upon the mean dorsal aortic blood pressure (Pda) and the heart rate (HR) in trout maintained under similar experimental situations. After intracerebroventricular injections, only U-I induced an increase in Pda while in non-cannulated trout, CRF only decreased the HR and elevated the heart rate variability by a presumed activation of the parasympathetic nervous system activity to the heart. The CRF antagonist, the α-helical CRF9-41 blocked these central actions of CRF. After intra-arterial (IA) injections, U-I induced a direct hypotensive action and an elevation in HR. This hypotensive phase was reversed to hypertension by the release of catecholamines. IA injection of CRF caused no change in Pda or HR. These cardiovascular effects are compared with the much better established actions of CRF and the orthologous urocortins in mammals.

KW - Blood pressure

KW - Brain

KW - Catecholamines

KW - CRF

KW - Heart rate

KW - Heart rate variability

KW - Peripheral circulation

KW - Stress

KW - Trout

KW - Urotensin-I

UR - https://www.scopus.com/pages/publications/32644458372

U2 - 10.1016/j.ygcen.2005.11.007

DO - 10.1016/j.ygcen.2005.11.007

M3 - Review article

C2 - 16386738

AN - SCOPUS:32644458372

SN - 0016-6480

VL - 146

SP - 56

EP - 61

JO - General and Comparative Endocrinology

JF - General and Comparative Endocrinology

IS - 1

ER -

Cardiovascular actions of the stress-related neurohormonal peptides, corticotropin-releasing factor and urotensin-I in the trout Oncorhynchus mykiss

Abstract

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Keywords

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