Carbon quantum dot-NO photoreleaser nanohybrids for two-photon phototherapy of hypoxic tumors

Colin Fowley, AP McHale, Bridgeen McCaughan, A. Fraix, S. Sortino, J Callan

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

We report a conjugate between carbon quantum dots and a NO photoreleaser able to photogenerate the anticancer NO radical via an energy transfer mechanism. This nanohybrid proved toxic to cancer cells in vitro and significantly reduced tumor volume in mice bearing human xenograft BxPC-3 pancreatic tumors upon two-photon excitation with the highly biocompatible 800 nm light. This journal is © The Royal Society of Chemistry.
Original languageEnglish
Pages (from-to)81-84
JournalChemical Communications
Volume51
Issue number1
DOIs
Publication statusPublished - 5 Nov 2014

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Keywords

  • antineoplastic agent
  • biomaterial
  • carbon
  • carbon quantum dot nitric oxide photoreleaser nanohybrid conjugate
  • carboxylic acid
  • nitric oxide
  • quantum dot
  • unclassified drug
  • nanomaterial
  • animal experiment
  • animal model
  • Article
  • cancer cell
  • controlled study
  • energy transfer
  • excitation
  • fluorescence microscopy
  • in vitro study
  • mouse
  • nonhuman
  • pancreas tumor
  • photochemotherapy
  • photon therapy
  • tumor volume
  • two photon phototherapy
  • xenograft
  • animal
  • Bagg albino mouse
  • cell survival
  • chemistry
  • drug effects
  • HeLa cell line
  • human
  • light
  • nanomedicine
  • Pancreatic Neoplasms
  • photon
  • phototherapy
  • SCID mouse
  • tumor cell line
  • Animals
  • Carbon
  • Cell Line
  • Tumor
  • Cell Survival
  • HeLa Cells
  • Humans
  • Light
  • Mice
  • Inbred BALB C
  • SCID
  • Nanomedicine
  • Nanostructures
  • Nitric Oxide
  • Photons
  • Phototherapy
  • Quantum Dots
  • Transplantation
  • Heterologous

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