Captopril and its synthesis from chiral intermediates

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Captopril is an antihypertensive agent that inhibits the angiotensin-converting enzyme of the renin-angiotensin system. Chiral intermediates are used in the synthesis of the drug. These intermediates are obtained by resolution of racemic compounds or by chemical, biocatalytic methods and or by asymmetric synthesis by biocatalytic process. This article reviews the various chemical and biochemical processes involved in the synthesis of the chiral drug, including the pharmacological action of captopril. (C) 2001 Society of Chemical Industry.
LanguageEnglish
Pages123-127
JournalJournal of Chemical Technology and Biotechnology
Volume76
Issue number2
Publication statusPublished - Feb 2001

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Captopril
Angiotensins
Peptidyl-Dipeptidase A
Renin
Pharmaceutical Preparations
Antihypertensive Agents

Cite this

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title = "Captopril and its synthesis from chiral intermediates",
abstract = "Captopril is an antihypertensive agent that inhibits the angiotensin-converting enzyme of the renin-angiotensin system. Chiral intermediates are used in the synthesis of the drug. These intermediates are obtained by resolution of racemic compounds or by chemical, biocatalytic methods and or by asymmetric synthesis by biocatalytic process. This article reviews the various chemical and biochemical processes involved in the synthesis of the chiral drug, including the pharmacological action of captopril. (C) 2001 Society of Chemical Industry.",
author = "RR Chirumamilla and R Marchant and {Singh - Nee Nigam}, Poonam",
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Captopril and its synthesis from chiral intermediates. / Chirumamilla, RR; Marchant, R; Singh - Nee Nigam, Poonam.

In: Journal of Chemical Technology and Biotechnology, Vol. 76, No. 2, 02.2001, p. 123-127.

Research output: Contribution to journalArticle

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T1 - Captopril and its synthesis from chiral intermediates

AU - Chirumamilla, RR

AU - Marchant, R

AU - Singh - Nee Nigam, Poonam

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N2 - Captopril is an antihypertensive agent that inhibits the angiotensin-converting enzyme of the renin-angiotensin system. Chiral intermediates are used in the synthesis of the drug. These intermediates are obtained by resolution of racemic compounds or by chemical, biocatalytic methods and or by asymmetric synthesis by biocatalytic process. This article reviews the various chemical and biochemical processes involved in the synthesis of the chiral drug, including the pharmacological action of captopril. (C) 2001 Society of Chemical Industry.

AB - Captopril is an antihypertensive agent that inhibits the angiotensin-converting enzyme of the renin-angiotensin system. Chiral intermediates are used in the synthesis of the drug. These intermediates are obtained by resolution of racemic compounds or by chemical, biocatalytic methods and or by asymmetric synthesis by biocatalytic process. This article reviews the various chemical and biochemical processes involved in the synthesis of the chiral drug, including the pharmacological action of captopril. (C) 2001 Society of Chemical Industry.

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JO - Journal of Chemical Technology and Biotechnology

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