Cannabinoid receptor agonist WIN 55,212-2 inhibits rat cortical dialysate gamma-aminobutyric acid levels.

L Ferraro, M C Tomasini, T Cassano, B W Bebe, A Siniscalchi, W T O'Connor, Pamela Magee, S Tanganelli, V Cuomo, T Antonelli

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

The effects of the cannabinoid receptor agonist WIN 55,212-2 (0.1-5 mg/kg i.p.) on endogenous extracellular gamma-aminobutyric acid (GABA) levels in the cerebral cortex of the awake rat was investigated by using microdialysis. WIN 55,212-2 (1 and 5 mg/kg i.p.) was associated with a concentration-dependent decrease in dialysate GABA levels (-16% +/- 4% and -26% +/- 4% of basal values, respectively). The WIN 55,212-2 (5 mg/kg i.p.) induced-inhibition was counteracted by a dose (0.1 mg/kg i.p.) of the CB(1) receptor antagonist SR141716A, which by itself was without effect on cortical GABA levels. These findings suggest that cannabinoids decrease cortical GABA levels in vivo, an action that might underlie some of the cognitive and behavioral effects of acute exposure to marijuana.
LanguageEnglish
Pages298-302
JournalJournal of Neuroscience Research
Volume66
Issue number2
Publication statusPublished - 2001

Fingerprint

Cannabinoid Receptor Agonists
Dialysis Solutions
gamma-Aminobutyric Acid
rimonabant
Cannabinoids
Microdialysis
Cannabis
Cerebral Cortex
Win 55212-2

Cite this

Ferraro, L., Tomasini, M. C., Cassano, T., Bebe, B. W., Siniscalchi, A., O'Connor, W. T., ... Antonelli, T. (2001). Cannabinoid receptor agonist WIN 55,212-2 inhibits rat cortical dialysate gamma-aminobutyric acid levels. Journal of Neuroscience Research, 66(2), 298-302.
Ferraro, L ; Tomasini, M C ; Cassano, T ; Bebe, B W ; Siniscalchi, A ; O'Connor, W T ; Magee, Pamela ; Tanganelli, S ; Cuomo, V ; Antonelli, T. / Cannabinoid receptor agonist WIN 55,212-2 inhibits rat cortical dialysate gamma-aminobutyric acid levels. In: Journal of Neuroscience Research. 2001 ; Vol. 66, No. 2. pp. 298-302.
@article{0394f0f6a0ed4f228fff87bb0af86bb3,
title = "Cannabinoid receptor agonist WIN 55,212-2 inhibits rat cortical dialysate gamma-aminobutyric acid levels.",
abstract = "The effects of the cannabinoid receptor agonist WIN 55,212-2 (0.1-5 mg/kg i.p.) on endogenous extracellular gamma-aminobutyric acid (GABA) levels in the cerebral cortex of the awake rat was investigated by using microdialysis. WIN 55,212-2 (1 and 5 mg/kg i.p.) was associated with a concentration-dependent decrease in dialysate GABA levels (-16{\%} +/- 4{\%} and -26{\%} +/- 4{\%} of basal values, respectively). The WIN 55,212-2 (5 mg/kg i.p.) induced-inhibition was counteracted by a dose (0.1 mg/kg i.p.) of the CB(1) receptor antagonist SR141716A, which by itself was without effect on cortical GABA levels. These findings suggest that cannabinoids decrease cortical GABA levels in vivo, an action that might underlie some of the cognitive and behavioral effects of acute exposure to marijuana.",
author = "L Ferraro and Tomasini, {M C} and T Cassano and Bebe, {B W} and A Siniscalchi and O'Connor, {W T} and Pamela Magee and S Tanganelli and V Cuomo and T Antonelli",
year = "2001",
language = "English",
volume = "66",
pages = "298--302",
journal = "Journal of Neuroscience Research",
issn = "0360-4012",
number = "2",

}

Ferraro, L, Tomasini, MC, Cassano, T, Bebe, BW, Siniscalchi, A, O'Connor, WT, Magee, P, Tanganelli, S, Cuomo, V & Antonelli, T 2001, 'Cannabinoid receptor agonist WIN 55,212-2 inhibits rat cortical dialysate gamma-aminobutyric acid levels.', Journal of Neuroscience Research, vol. 66, no. 2, pp. 298-302.

Cannabinoid receptor agonist WIN 55,212-2 inhibits rat cortical dialysate gamma-aminobutyric acid levels. / Ferraro, L; Tomasini, M C; Cassano, T; Bebe, B W; Siniscalchi, A; O'Connor, W T; Magee, Pamela; Tanganelli, S; Cuomo, V; Antonelli, T.

In: Journal of Neuroscience Research, Vol. 66, No. 2, 2001, p. 298-302.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Cannabinoid receptor agonist WIN 55,212-2 inhibits rat cortical dialysate gamma-aminobutyric acid levels.

AU - Ferraro, L

AU - Tomasini, M C

AU - Cassano, T

AU - Bebe, B W

AU - Siniscalchi, A

AU - O'Connor, W T

AU - Magee, Pamela

AU - Tanganelli, S

AU - Cuomo, V

AU - Antonelli, T

PY - 2001

Y1 - 2001

N2 - The effects of the cannabinoid receptor agonist WIN 55,212-2 (0.1-5 mg/kg i.p.) on endogenous extracellular gamma-aminobutyric acid (GABA) levels in the cerebral cortex of the awake rat was investigated by using microdialysis. WIN 55,212-2 (1 and 5 mg/kg i.p.) was associated with a concentration-dependent decrease in dialysate GABA levels (-16% +/- 4% and -26% +/- 4% of basal values, respectively). The WIN 55,212-2 (5 mg/kg i.p.) induced-inhibition was counteracted by a dose (0.1 mg/kg i.p.) of the CB(1) receptor antagonist SR141716A, which by itself was without effect on cortical GABA levels. These findings suggest that cannabinoids decrease cortical GABA levels in vivo, an action that might underlie some of the cognitive and behavioral effects of acute exposure to marijuana.

AB - The effects of the cannabinoid receptor agonist WIN 55,212-2 (0.1-5 mg/kg i.p.) on endogenous extracellular gamma-aminobutyric acid (GABA) levels in the cerebral cortex of the awake rat was investigated by using microdialysis. WIN 55,212-2 (1 and 5 mg/kg i.p.) was associated with a concentration-dependent decrease in dialysate GABA levels (-16% +/- 4% and -26% +/- 4% of basal values, respectively). The WIN 55,212-2 (5 mg/kg i.p.) induced-inhibition was counteracted by a dose (0.1 mg/kg i.p.) of the CB(1) receptor antagonist SR141716A, which by itself was without effect on cortical GABA levels. These findings suggest that cannabinoids decrease cortical GABA levels in vivo, an action that might underlie some of the cognitive and behavioral effects of acute exposure to marijuana.

M3 - Article

VL - 66

SP - 298

EP - 302

JO - Journal of Neuroscience Research

T2 - Journal of Neuroscience Research

JF - Journal of Neuroscience Research

SN - 0360-4012

IS - 2

ER -

Ferraro L, Tomasini MC, Cassano T, Bebe BW, Siniscalchi A, O'Connor WT et al. Cannabinoid receptor agonist WIN 55,212-2 inhibits rat cortical dialysate gamma-aminobutyric acid levels. Journal of Neuroscience Research. 2001;66(2):298-302.