Brevinin-2-related peptide and its [D4K] analogue stimulate insulin release in vitro and improve glucose tolerance in mice fed a high fat diet.

Yasser Abdel-Wahab; Steven Patterson; Peter Flatt; M Conlon

Brevinin-2-related peptide and its [D4K] analogue stimulate insulin release in vitro and improve glucose tolerance in mice fed a high fat diet.

Yasser Abdel-Wahab
, Steven Patterson
, Peter Flatt
, M Conlon

Research output: Contribution to journal › Article › peer-review

Abstract

The cationic, alpha-helical frog skin antimicrobial peptide B2RP (brevinin-2-related peptide) shows sequence similarity to antimicrobial peptides belonging to the brevinin-2 family, but lacks the C-terminal cyclic heptapeptide domain (Cys-Lys-Xaa (4)-Cys). Synthetic B2RP produced a significant (p Lys enhanced the insulin-releasing potency (137% of basal rate at a concentration of 0.3 muM; p

Original language	English
Pages (from-to)	652-656
Journal	HORMONE AND METABOLIC RESEARCH
Volume	42(9)
Publication status	Published (in print/issue) - 2010

Cite this

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title = "Brevinin-2-related peptide and its [D4K] analogue stimulate insulin release in vitro and improve glucose tolerance in mice fed a high fat diet.",

abstract = "The cationic, alpha-helical frog skin antimicrobial peptide B2RP (brevinin-2-related peptide) shows sequence similarity to antimicrobial peptides belonging to the brevinin-2 family, but lacks the C-terminal cyclic heptapeptide domain (Cys-Lys-Xaa (4)-Cys). Synthetic B2RP produced a significant (p Lys enhanced the insulin-releasing potency (137\% of basal rate at a concentration of 0.3 muM; p",

author = "Yasser Abdel-Wahab and Steven Patterson and Peter Flatt and M Conlon",

year = "2010",

language = "English",

volume = "42(9)",

pages = "652--656",

journal = "HORMONE AND METABOLIC RESEARCH",

issn = "1439-4286",

publisher = "Georg Thieme Verlag",

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TY - JOUR

T1 - Brevinin-2-related peptide and its [D4K] analogue stimulate insulin release in vitro and improve glucose tolerance in mice fed a high fat diet.

AU - Abdel-Wahab, Yasser

AU - Patterson, Steven

AU - Flatt, Peter

AU - Conlon, M

PY - 2010

Y1 - 2010

N2 - The cationic, alpha-helical frog skin antimicrobial peptide B2RP (brevinin-2-related peptide) shows sequence similarity to antimicrobial peptides belonging to the brevinin-2 family, but lacks the C-terminal cyclic heptapeptide domain (Cys-Lys-Xaa (4)-Cys). Synthetic B2RP produced a significant (p Lys enhanced the insulin-releasing potency (137% of basal rate at a concentration of 0.3 muM; p

AB - The cationic, alpha-helical frog skin antimicrobial peptide B2RP (brevinin-2-related peptide) shows sequence similarity to antimicrobial peptides belonging to the brevinin-2 family, but lacks the C-terminal cyclic heptapeptide domain (Cys-Lys-Xaa (4)-Cys). Synthetic B2RP produced a significant (p Lys enhanced the insulin-releasing potency (137% of basal rate at a concentration of 0.3 muM; p

M3 - Article

SN - 1439-4286

VL - 42(9)

SP - 652

EP - 656

JO - HORMONE AND METABOLIC RESEARCH

JF - HORMONE AND METABOLIC RESEARCH

ER -

Brevinin-2-related peptide and its [D4K] analogue stimulate insulin release in vitro and improve glucose tolerance in mice fed a high fat diet.

Abstract

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