Brevinin-2-related peptide and its [D4K] analogue stimulate insulin release in vitro and improve glucose tolerance in mice fed a high fat diet.

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Abstract

The cationic, alpha-helical frog skin antimicrobial peptide B2RP (brevinin-2-related peptide) shows sequence similarity to antimicrobial peptides belonging to the brevinin-2 family, but lacks the C-terminal cyclic heptapeptide domain (Cys-Lys-Xaa (4)-Cys). Synthetic B2RP produced a significant (p Lys enhanced the insulin-releasing potency (137% of basal rate at a concentration of 0.3 muM; p
Original languageEnglish
Pages (from-to)652-656
JournalHORMONE AND METABOLIC RESEARCH
Volume42(9)
Publication statusPublished - 2010

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