Brevinin-2-related peptide and its [D4K] analogue stimulate insulin release in vitro and improve glucose tolerance in mice fed a high fat diet.

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Abstract

The cationic, alpha-helical frog skin antimicrobial peptide B2RP (brevinin-2-related peptide) shows sequence similarity to antimicrobial peptides belonging to the brevinin-2 family, but lacks the C-terminal cyclic heptapeptide domain (Cys-Lys-Xaa (4)-Cys). Synthetic B2RP produced a significant (p Lys enhanced the insulin-releasing potency (137% of basal rate at a concentration of 0.3 muM; p
LanguageEnglish
Pages652-656
JournalHORMONE AND METABOLIC RESEARCH
Volume42(9)
Publication statusPublished - 2010

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trypsinogen activation peptide
High Fat Diet
Insulin
Glucose
Peptides
Anura
Skin
In Vitro Techniques

Cite this

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title = "Brevinin-2-related peptide and its [D4K] analogue stimulate insulin release in vitro and improve glucose tolerance in mice fed a high fat diet.",
abstract = "The cationic, alpha-helical frog skin antimicrobial peptide B2RP (brevinin-2-related peptide) shows sequence similarity to antimicrobial peptides belonging to the brevinin-2 family, but lacks the C-terminal cyclic heptapeptide domain (Cys-Lys-Xaa (4)-Cys). Synthetic B2RP produced a significant (p Lys enhanced the insulin-releasing potency (137{\%} of basal rate at a concentration of 0.3 muM; p",
author = "Yasser Abdel-Wahab and Steven Patterson and Peter Flatt and M Conlon",
year = "2010",
language = "English",
volume = "42(9)",
pages = "652--656",
journal = "Hormone and Metabolic Research",
issn = "0018-5043",

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TY - JOUR

T1 - Brevinin-2-related peptide and its [D4K] analogue stimulate insulin release in vitro and improve glucose tolerance in mice fed a high fat diet.

AU - Abdel-Wahab, Yasser

AU - Patterson, Steven

AU - Flatt, Peter

AU - Conlon, M

PY - 2010

Y1 - 2010

N2 - The cationic, alpha-helical frog skin antimicrobial peptide B2RP (brevinin-2-related peptide) shows sequence similarity to antimicrobial peptides belonging to the brevinin-2 family, but lacks the C-terminal cyclic heptapeptide domain (Cys-Lys-Xaa (4)-Cys). Synthetic B2RP produced a significant (p Lys enhanced the insulin-releasing potency (137% of basal rate at a concentration of 0.3 muM; p

AB - The cationic, alpha-helical frog skin antimicrobial peptide B2RP (brevinin-2-related peptide) shows sequence similarity to antimicrobial peptides belonging to the brevinin-2 family, but lacks the C-terminal cyclic heptapeptide domain (Cys-Lys-Xaa (4)-Cys). Synthetic B2RP produced a significant (p Lys enhanced the insulin-releasing potency (137% of basal rate at a concentration of 0.3 muM; p

M3 - Article

VL - 42(9)

SP - 652

EP - 656

JO - Hormone and Metabolic Research

T2 - Hormone and Metabolic Research

JF - Hormone and Metabolic Research

SN - 0018-5043

ER -