BMI is related to elevated levels of Homocysteine in Type 1 individuals

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Objective: To determine, in individuals with Type 1 diabetes, if there is a relationship between plasma homocysteine (tHcy), antioxidant markers and body mass index (BMI).Methods: Ethical permission was obtained from the University of Ulster; Type 1 volunteers gave signed informed consent. Height and weight was measured and BMI calculated. Blood samples were collected and analyzed for haemoglobin (Hb), packed cell volume (PCV), % glycated Hb (HbA1C), folate, tHcy, and two endogenous antioxidant enzymes: Superoxide Dismutase (SOD) and Glutathione Peroxidise (GPx)Results: 21males completed the study with a mean age of 43.7 ± 2.8 years and a mean BMI of 27.94± 3.46 kg/m2. tHcy, SOD, GPx, Hb and %HbA1C were elevated among volunteers classified as overweight (BMI, 25-29.9 kg/m2). SOD was positively correlated with Hb and PCV (r=0.79 and 0.85, respectively) in overweight but not normal weight volunteers (BMI, 18.5-24.9 kg/m2). tHcy levels correlated positively with %HbA1C (r=0.92) in obese volunteers (BMI>30 kg/m2). tHcy was negatively correlated with folate (r=o.97), as expected, however only in normal weight volunteers. This relationship was lost in the overweight and obese volunteers.Conclusions: The elevated tHcy observed in overweight volunteers with Type 1 diabetes suggests that they may be susceptible to increased cardiovascular morbidity. Indeed, the loss of the normal negative correlation between tHcy and folate is concern and is an indication of the perturbed metabolism in overweight and obesity. Future studies are required to elucidate this finding with the inclusion of waist circumference in addition to BMI.Keywords: tHcy, BMI. Type 1 diabetes.
LanguageEnglish
Title of host publicationUnknown Host Publication
Pages70
Number of pages1
Volume5
Publication statusPublished - 2010
EventEuropean Childhood Obesity Group Conference - Dublin, Ireland.
Duration: 1 Jan 2010 → …

Conference

ConferenceEuropean Childhood Obesity Group Conference
Period1/01/10 → …

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Homocysteine
Body Mass Index
Volunteers
Type 1 Diabetes Mellitus
Folic Acid
Superoxide Dismutase
Hemoglobins
Cell Size
Weights and Measures
Glutathione
Healthy Volunteers
Antioxidants
Glycosylated Hemoglobin A
Waist Circumference
Informed Consent
Obesity
Morbidity
Enzymes

Cite this

@inproceedings{f9be57c77bca434fac31c257a24f6737,
title = "BMI is related to elevated levels of Homocysteine in Type 1 individuals",
abstract = "Objective: To determine, in individuals with Type 1 diabetes, if there is a relationship between plasma homocysteine (tHcy), antioxidant markers and body mass index (BMI).Methods: Ethical permission was obtained from the University of Ulster; Type 1 volunteers gave signed informed consent. Height and weight was measured and BMI calculated. Blood samples were collected and analyzed for haemoglobin (Hb), packed cell volume (PCV), {\%} glycated Hb (HbA1C), folate, tHcy, and two endogenous antioxidant enzymes: Superoxide Dismutase (SOD) and Glutathione Peroxidise (GPx)Results: 21males completed the study with a mean age of 43.7 ± 2.8 years and a mean BMI of 27.94± 3.46 kg/m2. tHcy, SOD, GPx, Hb and {\%}HbA1C were elevated among volunteers classified as overweight (BMI, 25-29.9 kg/m2). SOD was positively correlated with Hb and PCV (r=0.79 and 0.85, respectively) in overweight but not normal weight volunteers (BMI, 18.5-24.9 kg/m2). tHcy levels correlated positively with {\%}HbA1C (r=0.92) in obese volunteers (BMI>30 kg/m2). tHcy was negatively correlated with folate (r=o.97), as expected, however only in normal weight volunteers. This relationship was lost in the overweight and obese volunteers.Conclusions: The elevated tHcy observed in overweight volunteers with Type 1 diabetes suggests that they may be susceptible to increased cardiovascular morbidity. Indeed, the loss of the normal negative correlation between tHcy and folate is concern and is an indication of the perturbed metabolism in overweight and obesity. Future studies are required to elucidate this finding with the inclusion of waist circumference in addition to BMI.Keywords: tHcy, BMI. Type 1 diabetes.",
author = "Hannon-Fletcher, {Mary P.A}",
year = "2010",
language = "English",
volume = "5",
pages = "70",
booktitle = "Unknown Host Publication",

}

Hannon-Fletcher, MPA 2010, BMI is related to elevated levels of Homocysteine in Type 1 individuals. in Unknown Host Publication. vol. 5, pp. 70, European Childhood Obesity Group Conference, 1/01/10.

BMI is related to elevated levels of Homocysteine in Type 1 individuals. / Hannon-Fletcher, Mary P.A.

Unknown Host Publication. Vol. 5 2010. p. 70.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

TY - GEN

T1 - BMI is related to elevated levels of Homocysteine in Type 1 individuals

AU - Hannon-Fletcher, Mary P.A

PY - 2010

Y1 - 2010

N2 - Objective: To determine, in individuals with Type 1 diabetes, if there is a relationship between plasma homocysteine (tHcy), antioxidant markers and body mass index (BMI).Methods: Ethical permission was obtained from the University of Ulster; Type 1 volunteers gave signed informed consent. Height and weight was measured and BMI calculated. Blood samples were collected and analyzed for haemoglobin (Hb), packed cell volume (PCV), % glycated Hb (HbA1C), folate, tHcy, and two endogenous antioxidant enzymes: Superoxide Dismutase (SOD) and Glutathione Peroxidise (GPx)Results: 21males completed the study with a mean age of 43.7 ± 2.8 years and a mean BMI of 27.94± 3.46 kg/m2. tHcy, SOD, GPx, Hb and %HbA1C were elevated among volunteers classified as overweight (BMI, 25-29.9 kg/m2). SOD was positively correlated with Hb and PCV (r=0.79 and 0.85, respectively) in overweight but not normal weight volunteers (BMI, 18.5-24.9 kg/m2). tHcy levels correlated positively with %HbA1C (r=0.92) in obese volunteers (BMI>30 kg/m2). tHcy was negatively correlated with folate (r=o.97), as expected, however only in normal weight volunteers. This relationship was lost in the overweight and obese volunteers.Conclusions: The elevated tHcy observed in overweight volunteers with Type 1 diabetes suggests that they may be susceptible to increased cardiovascular morbidity. Indeed, the loss of the normal negative correlation between tHcy and folate is concern and is an indication of the perturbed metabolism in overweight and obesity. Future studies are required to elucidate this finding with the inclusion of waist circumference in addition to BMI.Keywords: tHcy, BMI. Type 1 diabetes.

AB - Objective: To determine, in individuals with Type 1 diabetes, if there is a relationship between plasma homocysteine (tHcy), antioxidant markers and body mass index (BMI).Methods: Ethical permission was obtained from the University of Ulster; Type 1 volunteers gave signed informed consent. Height and weight was measured and BMI calculated. Blood samples were collected and analyzed for haemoglobin (Hb), packed cell volume (PCV), % glycated Hb (HbA1C), folate, tHcy, and two endogenous antioxidant enzymes: Superoxide Dismutase (SOD) and Glutathione Peroxidise (GPx)Results: 21males completed the study with a mean age of 43.7 ± 2.8 years and a mean BMI of 27.94± 3.46 kg/m2. tHcy, SOD, GPx, Hb and %HbA1C were elevated among volunteers classified as overweight (BMI, 25-29.9 kg/m2). SOD was positively correlated with Hb and PCV (r=0.79 and 0.85, respectively) in overweight but not normal weight volunteers (BMI, 18.5-24.9 kg/m2). tHcy levels correlated positively with %HbA1C (r=0.92) in obese volunteers (BMI>30 kg/m2). tHcy was negatively correlated with folate (r=o.97), as expected, however only in normal weight volunteers. This relationship was lost in the overweight and obese volunteers.Conclusions: The elevated tHcy observed in overweight volunteers with Type 1 diabetes suggests that they may be susceptible to increased cardiovascular morbidity. Indeed, the loss of the normal negative correlation between tHcy and folate is concern and is an indication of the perturbed metabolism in overweight and obesity. Future studies are required to elucidate this finding with the inclusion of waist circumference in addition to BMI.Keywords: tHcy, BMI. Type 1 diabetes.

M3 - Conference contribution

VL - 5

SP - 70

BT - Unknown Host Publication

ER -