Blood Flow Regulation and Oxidative Stress During Submaximal Cycling Exercise in Patients with Cystic Fibrosis

Matthew Tucker, Breana Berry, Nichole Seigler, Gareth W Davison, John C Quindry, Dabney Eidson, Kathleen McKie, Ryan Harris

Research output: Contribution to journalArticle

Abstract

Background:The impact of bloodflow regulation and oxidative stress during exercise in cysticfibrosis (CF) has yet to be investigated.Methods:A maximal graded exercise test was conducted to determine exercise capacity (VO2peak) and peak workload in 14 pediatric patientswith mild CF (age 14 ± 3 y, FEV193 ± 16 % predicted) and 14 demographically-matched controls. On a separate visit, participants performedsubmaximal cycling up to 60% of peak workload where brachial artery blood velocity was determined using Doppler ultrasound. Retrograde andantegrade components were further analyzed as indices of bloodflow regulation.Results:The cumulative AUC for retrograde velocity was lower in patients versus controls (1770 ± 554 vs. 3440 ± 522 cm,P= 0.038). In addition,an exaggerated oxidative stress response during exercise occurred in patients only (P= 0.004).Conclusion:These data suggest that patients with mild CF exhibit impaired bloodflow regulation and an exaggerated oxidative stress response tosubmaximal exercise.
LanguageEnglish
Pages256-263
Number of pages8
JournalJournal of Cystic Fibrosis
Volume1
Early online date12 Oct 2017
Publication statusE-pub ahead of print - 12 Oct 2017

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Cystic Fibrosis
Oxidative Stress
Exercise
Workload
Doppler Ultrasonography
Brachial Artery
Exercise Test
Area Under Curve
Pediatrics

Keywords

  • Exercise
  • Cystic Fibrosis
  • Oxidative Stress

Cite this

Tucker, M., Berry, B., Seigler, N., Davison, G. W., Quindry, J. C., Eidson, D., ... Harris, R. (2017). Blood Flow Regulation and Oxidative Stress During Submaximal Cycling Exercise in Patients with Cystic Fibrosis. Journal of Cystic Fibrosis, 1, 256-263.
Tucker, Matthew ; Berry, Breana ; Seigler, Nichole ; Davison, Gareth W ; Quindry, John C ; Eidson, Dabney ; McKie, Kathleen ; Harris, Ryan. / Blood Flow Regulation and Oxidative Stress During Submaximal Cycling Exercise in Patients with Cystic Fibrosis. In: Journal of Cystic Fibrosis. 2017 ; Vol. 1. pp. 256-263.
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Tucker, M, Berry, B, Seigler, N, Davison, GW, Quindry, JC, Eidson, D, McKie, K & Harris, R 2017, 'Blood Flow Regulation and Oxidative Stress During Submaximal Cycling Exercise in Patients with Cystic Fibrosis', Journal of Cystic Fibrosis, vol. 1, pp. 256-263.

Blood Flow Regulation and Oxidative Stress During Submaximal Cycling Exercise in Patients with Cystic Fibrosis. / Tucker, Matthew; Berry, Breana; Seigler, Nichole; Davison, Gareth W; Quindry, John C; Eidson, Dabney; McKie, Kathleen; Harris, Ryan.

In: Journal of Cystic Fibrosis, Vol. 1, 12.10.2017, p. 256-263.

Research output: Contribution to journalArticle

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AU - Tucker, Matthew

AU - Berry, Breana

AU - Seigler, Nichole

AU - Davison, Gareth W

AU - Quindry, John C

AU - Eidson, Dabney

AU - McKie, Kathleen

AU - Harris, Ryan

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N2 - Background:The impact of bloodflow regulation and oxidative stress during exercise in cysticfibrosis (CF) has yet to be investigated.Methods:A maximal graded exercise test was conducted to determine exercise capacity (VO2peak) and peak workload in 14 pediatric patientswith mild CF (age 14 ± 3 y, FEV193 ± 16 % predicted) and 14 demographically-matched controls. On a separate visit, participants performedsubmaximal cycling up to 60% of peak workload where brachial artery blood velocity was determined using Doppler ultrasound. Retrograde andantegrade components were further analyzed as indices of bloodflow regulation.Results:The cumulative AUC for retrograde velocity was lower in patients versus controls (1770 ± 554 vs. 3440 ± 522 cm,P= 0.038). In addition,an exaggerated oxidative stress response during exercise occurred in patients only (P= 0.004).Conclusion:These data suggest that patients with mild CF exhibit impaired bloodflow regulation and an exaggerated oxidative stress response tosubmaximal exercise.

AB - Background:The impact of bloodflow regulation and oxidative stress during exercise in cysticfibrosis (CF) has yet to be investigated.Methods:A maximal graded exercise test was conducted to determine exercise capacity (VO2peak) and peak workload in 14 pediatric patientswith mild CF (age 14 ± 3 y, FEV193 ± 16 % predicted) and 14 demographically-matched controls. On a separate visit, participants performedsubmaximal cycling up to 60% of peak workload where brachial artery blood velocity was determined using Doppler ultrasound. Retrograde andantegrade components were further analyzed as indices of bloodflow regulation.Results:The cumulative AUC for retrograde velocity was lower in patients versus controls (1770 ± 554 vs. 3440 ± 522 cm,P= 0.038). In addition,an exaggerated oxidative stress response during exercise occurred in patients only (P= 0.004).Conclusion:These data suggest that patients with mild CF exhibit impaired bloodflow regulation and an exaggerated oxidative stress response tosubmaximal exercise.

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