Blood Flow Regulation and Oxidative Stress During Submaximal Cycling Exercise in Patients with Cystic Fibrosis

Matthew Tucker; Breana Berry; Nichole Seigler; Gareth W Davison; John C Quindry; Dabney Eidson; Kathleen McKie; Ryan Harris

Blood Flow Regulation and Oxidative Stress During Submaximal Cycling Exercise in Patients with Cystic Fibrosis

Matthew Tucker, Breana Berry, Nichole Seigler, Gareth W Davison, John C Quindry, Dabney Eidson, Kathleen McKie, Ryan Harris

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Abstract

Background:The impact of bloodflow regulation and oxidative stress during exercise in cysticfibrosis (CF) has yet to be investigated.Methods:A maximal graded exercise test was conducted to determine exercise capacity (VO2peak) and peak workload in 14 pediatric patientswith mild CF (age 14 ± 3 y, FEV193 ± 16 % predicted) and 14 demographically-matched controls. On a separate visit, participants performedsubmaximal cycling up to 60% of peak workload where brachial artery blood velocity was determined using Doppler ultrasound. Retrograde andantegrade components were further analyzed as indices of bloodflow regulation.Results:The cumulative AUC for retrograde velocity was lower in patients versus controls (1770 ± 554 vs. 3440 ± 522 cm,P= 0.038). In addition,an exaggerated oxidative stress response during exercise occurred in patients only (P= 0.004).Conclusion:These data suggest that patients with mild CF exhibit impaired bloodflow regulation and an exaggerated oxidative stress response tosubmaximal exercise.

Original language	English
Pages (from-to)	256-263
Number of pages	8
Journal	Journal of Cystic Fibrosis
Volume	1
Early online date	12 Oct 2017
Publication status	Published online - 12 Oct 2017

Keywords

Exercise
Cystic Fibrosis
Oxidative Stress

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Manuscript File JCF Revised Clean 8Author Accepted Manuscript, 70 KB
PIIS1569199317308780Final published version, 560 KB

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title = "Blood Flow Regulation and Oxidative Stress During Submaximal Cycling Exercise in Patients with Cystic Fibrosis",

abstract = "Background:The impact of bloodflow regulation and oxidative stress during exercise in cysticfibrosis (CF) has yet to be investigated.Methods:A maximal graded exercise test was conducted to determine exercise capacity (VO2peak) and peak workload in 14 pediatric patientswith mild CF (age 14 ± 3 y, FEV193 ± 16 % predicted) and 14 demographically-matched controls. On a separate visit, participants performedsubmaximal cycling up to 60% of peak workload where brachial artery blood velocity was determined using Doppler ultrasound. Retrograde andantegrade components were further analyzed as indices of bloodflow regulation.Results:The cumulative AUC for retrograde velocity was lower in patients versus controls (1770 ± 554 vs. 3440 ± 522 cm,P= 0.038). In addition,an exaggerated oxidative stress response during exercise occurred in patients only (P= 0.004).Conclusion:These data suggest that patients with mild CF exhibit impaired bloodflow regulation and an exaggerated oxidative stress response tosubmaximal exercise.",

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AU - Tucker, Matthew

AU - Berry, Breana

AU - Seigler, Nichole

AU - Davison, Gareth W

AU - Quindry, John C

AU - Eidson, Dabney

AU - McKie, Kathleen

AU - Harris, Ryan

PY - 2017/10/12

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N2 - Background:The impact of bloodflow regulation and oxidative stress during exercise in cysticfibrosis (CF) has yet to be investigated.Methods:A maximal graded exercise test was conducted to determine exercise capacity (VO2peak) and peak workload in 14 pediatric patientswith mild CF (age 14 ± 3 y, FEV193 ± 16 % predicted) and 14 demographically-matched controls. On a separate visit, participants performedsubmaximal cycling up to 60% of peak workload where brachial artery blood velocity was determined using Doppler ultrasound. Retrograde andantegrade components were further analyzed as indices of bloodflow regulation.Results:The cumulative AUC for retrograde velocity was lower in patients versus controls (1770 ± 554 vs. 3440 ± 522 cm,P= 0.038). In addition,an exaggerated oxidative stress response during exercise occurred in patients only (P= 0.004).Conclusion:These data suggest that patients with mild CF exhibit impaired bloodflow regulation and an exaggerated oxidative stress response tosubmaximal exercise.

AB - Background:The impact of bloodflow regulation and oxidative stress during exercise in cysticfibrosis (CF) has yet to be investigated.Methods:A maximal graded exercise test was conducted to determine exercise capacity (VO2peak) and peak workload in 14 pediatric patientswith mild CF (age 14 ± 3 y, FEV193 ± 16 % predicted) and 14 demographically-matched controls. On a separate visit, participants performedsubmaximal cycling up to 60% of peak workload where brachial artery blood velocity was determined using Doppler ultrasound. Retrograde andantegrade components were further analyzed as indices of bloodflow regulation.Results:The cumulative AUC for retrograde velocity was lower in patients versus controls (1770 ± 554 vs. 3440 ± 522 cm,P= 0.038). In addition,an exaggerated oxidative stress response during exercise occurred in patients only (P= 0.004).Conclusion:These data suggest that patients with mild CF exhibit impaired bloodflow regulation and an exaggerated oxidative stress response tosubmaximal exercise.

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KW - Cystic Fibrosis

KW - Oxidative Stress

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JO - Journal of Cystic Fibrosis

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ER -

Blood Flow Regulation and Oxidative Stress During Submaximal Cycling Exercise in Patients with Cystic Fibrosis

Abstract

Keywords

UN SDGs

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