Biphasic Effect of Curcuminoids on Oxidation of Postprandial Chylomicrons

Peter McPherson, Niamh McKenna, Dílis Clare

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Chylomicrons are large, triglyceride-rich lipoproteins that transport dietary lipids and lipophilic micronutrients through the lymphatic system and into the venous circulation. They therefore represent a valuable means of investigating the bioavailability of a range of bioactive molecules. Curcuminoids have a complex reputation, with most in vitro studies suggesting a beneficial effect (e.g., as an antioxidant), while in vivo work is often, at best, equivocal. We have prepared a curcuminoid extract from fresh turmeric and investigated the transfer of curcuminoids to chylomicrons by rapid ultracentrifugation. We subsequently characterized the chylomicrons in terms of their susceptibility to oxidation. There was a dose-dependent relationship between the curcuminoid level in chylomicrons and decreased levels of preformed lipid hydroperoxides (P 
Original languageEnglish
Pages (from-to)1340-1343
Number of pages4
JournalJournal of Medicinal Food
Issue number12
Early online date7 Sept 2021
Publication statusPublished (in print/issue) - 17 Dec 2021


  • bioavailability
  • conjugated dienes
  • hormesis
  • inflammation
  • lipid hydroperoxide
  • micronutrients
  • paraoxonase
  • turmeric


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