Biosurfactants’ Potential Role in Combating COVID-19 and Similar Future Microbial Threats

Pınar Aytar Çelik, Enuh Blaise Manga, Ahmet Çabuk, Ibrahim M Banat

Research output: Contribution to journalReview articlepeer-review

35 Citations (Scopus)
40 Downloads (Pure)


During 2020, the world has experienced extreme vulnerability in the face of a disease outbreak. The coronavirus disease 2019 (COVID-19) pandemic discovered in China and rapidly spread across the globe, infecting millions, causing hundreds of thousands of deaths, and severe downturns in the economies of countries worldwide. Biosurfactants can play a significant role in the prevention, control and treatment of diseases caused by these pathogenic agents through various therapeutic, pharmaceutical, environmental and hygiene approaches. Biosurfactants have the potential to inhibit microbial species with virulent intrinsic characteristics capable of developing diseases with high morbidity and mortality, as well as interrupting their spread through environmental and hygiene interventions. This is possible due to their antimicrobial activity, ability to interact with cells forming micelles and to interact with the immune system, and compatibility with relevant processes such as nanoparticle synthesis. They, therefore, can be applied in developing innovative and more effective pharmaceutical, therapeutics, sustainable and friendly environmental management approaches, less toxic formulations, and more efficient cleaning agents. These approaches can be easily integrated into
relevant product development pipelines and implemented as measures for combating and managing pandemics. This review examines the potential approaches of biosurfactants as useful molecules in fighting microbial pathogens both known and previously unknown, such as COVID-19.
Original languageEnglish
Article number11334
Number of pages16
JournalApplied Sciences
Early online date31 Dec 2020
Publication statusPublished online - 31 Dec 2020


  • biosurfactants; COVID-19; antiviral; antimicrobial


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