Biosensors for screening kinase inhibitors

Nikhil Bhalla, Pedro Estrela

Research output: Contribution to journalReview article

Abstract

For successful drug discovery it is important to understand the fundamentals of the underlying causes and consequences of the diseases for which the drug is being developed. One such physiological process in eukaryotic cells is protein phosphorylation, which is the main post-translational modification of proteins responsible for the onset or progression of Alzheimer's disease, diabetes and various cancers. Protein phosphorylation is facilitated by kinases and inhibitors of kinases act as drugs in controlling or curing these diseases by reducing protein phosphorylation. This review discusses the technologies capable of detecting kinase activity and screening candidate compounds to identify novel inhibitors of protein kinases.

LanguageEnglish
Pages2470-2481
Number of pages12
JournalCurrent Topics in Medicinal Chemistry
Volume17
Issue number22
DOIs
Publication statusPublished - 1 Sep 2017

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Biosensing Techniques
Phosphotransferases
Phosphorylation
Physiological Phenomena
Proteins
Eukaryotic Cells
Drug Discovery
Post Translational Protein Processing
Protein Kinase Inhibitors
Pharmaceutical Preparations
Alzheimer Disease
Technology
Neoplasms

Keywords

  • Biosensors
  • Cancer
  • Drug discovery
  • Protein phosphorylation
  • Screening kinase inhibitors

Cite this

Bhalla, Nikhil ; Estrela, Pedro. / Biosensors for screening kinase inhibitors. 2017 ; Vol. 17, No. 22. pp. 2470-2481.
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Biosensors for screening kinase inhibitors. / Bhalla, Nikhil; Estrela, Pedro.

Vol. 17, No. 22, 01.09.2017, p. 2470-2481.

Research output: Contribution to journalReview article

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