TY - JOUR
T1 - Biomolecule Damage (DNA and Lipid) is elevated in patients with Type 1 diabetes with and without diabetic complications.
AU - Hannon-Fletcher, Mary P.A
AU - O'Kane, Maurice
AU - Moles, Ken
AU - Barnett, Yvonne
AU - Weatherup, Colin
PY - 2014/6/15
Y1 - 2014/6/15
N2 - There is strong evidence that oxidative stress is involved in the aetiology and pathogenesis of diabetes and its complications. Increased production of reactive oxygen species in vivo can lead to cellular biomolecule damage, such as lipid peroxidation and DNA damage.The aim of this study was to determine the extent of this damage by measuring in vivo antioxidant status, levels of lipid peroxidation, and levels of neutrophil DNA damage in 50 participants with type 1 diabetes and 50 age- and sex-matched, healthy controls.Gylcaemic control (%HbA1c) was relatively good with a group mean of 7.71% which increased to 8.12 % in those with complications. Compared to the control group there were significantly elevated levels of neutrophil DNA damage (% tail DNA, p
AB - There is strong evidence that oxidative stress is involved in the aetiology and pathogenesis of diabetes and its complications. Increased production of reactive oxygen species in vivo can lead to cellular biomolecule damage, such as lipid peroxidation and DNA damage.The aim of this study was to determine the extent of this damage by measuring in vivo antioxidant status, levels of lipid peroxidation, and levels of neutrophil DNA damage in 50 participants with type 1 diabetes and 50 age- and sex-matched, healthy controls.Gylcaemic control (%HbA1c) was relatively good with a group mean of 7.71% which increased to 8.12 % in those with complications. Compared to the control group there were significantly elevated levels of neutrophil DNA damage (% tail DNA, p
UR - https://pure.ulster.ac.uk/en/searchAll/index/?search=11461510&pageSize=25&showAdvanced=false&allConcepts=true&inferConcepts=true&searchBy=PartOfNameOrTitle
U2 - 10.6000/1929-5634.2014.03.02.8
DO - 10.6000/1929-5634.2014.03.02.8
M3 - Article
SN - 1929-5634
VL - 3
SP - 95
EP - 102
JO - Journal of Nutritional Therapeutics
JF - Journal of Nutritional Therapeutics
IS - 2
ER -
