Biomarkers of intake for coffee, tea, and sweetened beverages

Joseph Rothwell, Francisco Madrid-Gambin, Mar Garcia-Aloy, Cristina Andres-Lacueva, Caomhan Logue, Alison M. Gallagher, Carina Mack, Sabine E. Kulling, Qian Gao, Giulia Praticó, Lars O. Dragsted, Augustin Scalbert

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

Non-alcoholic beverages are important sources of nutrients and bioactive compounds that may influence human health and increase or decrease the risk of chronic diseases. A wide variety of beverage constituents are absorbed in the gut, found in the systemic circulation and excreted in urine. They may be used as compliance markers in intervention studies or as biomarkers of intake to improve measurements of beverage consumption in cohort studies and reveal new associations with disease outcomes that may have been overlooked when using dietary questionnaires. Here, biomarkers of intake of some major non-alcoholic beverages—coffee, tea, sugar-sweetened beverages, and low-calorie-sweetened beverages—are reviewed. Results from dietary intervention studies and observational studies are reviewed and analyzed, and respective strengths and weaknesses of the various identified biomarkers discussed. A variety of compounds derived from phenolic acids, alkaloids, and terpenes were shown to be associated with coffee intake and trigonelline and cyclo(isoleucylprolyl) showed a particularly high specificity for coffee intake. Epigallocatechin and 4′-O-methylepigallocatechin appear to be the most sensitive and specific biomarkers for green or black tea, while 4-O-methylgallic acid may be used to assess black tea consumption. Intake of sugar-sweetened beverages has been assessed through the measurement of carbon-13 enrichment of whole blood or of blood alanine in North America where sugar from sugarcane or corn is used as a main ingredient. The most useful biomarkers for low-calorie-sweetened beverages are the low-calorie sweeteners themselves. Further studies are needed to validate these biomarkers in larger and independent populations and to further evaluate their specificity, reproducibility over time, and fields of application.
LanguageEnglish
Number of pages18
JournalGenes and Nutrition
Volume13
Issue number15
DOIs
Publication statusPublished - 4 Jul 2018

Fingerprint

Coffee
Beverages
Tea
Biomarkers
Sweetening Agents
Saccharum
Terpenes
North America
Alkaloids
Alanine
Compliance
Zea mays
Observational Studies
Chronic Disease
Cohort Studies
Carbon
Urine
Food
Health
Population

Keywords

  • Non-alcoholic beverages
  • Coffee
  • Tea
  • Sugar-sweetened beverages
  • Low-calorie sweetened beverages
  • Biomarkers
  • Intake

Cite this

Rothwell, J., Madrid-Gambin, F., Garcia-Aloy, M., Andres-Lacueva, C., Logue, C., Gallagher, A. M., ... Scalbert, A. (2018). Biomarkers of intake for coffee, tea, and sweetened beverages. Genes and Nutrition, 13(15). https://doi.org/10.1186/s12263-018-0607-5
Rothwell, Joseph ; Madrid-Gambin, Francisco ; Garcia-Aloy, Mar ; Andres-Lacueva, Cristina ; Logue, Caomhan ; Gallagher, Alison M. ; Mack, Carina ; Kulling, Sabine E. ; Gao, Qian ; Praticó, Giulia ; Dragsted, Lars O. ; Scalbert, Augustin. / Biomarkers of intake for coffee, tea, and sweetened beverages. In: Genes and Nutrition. 2018 ; Vol. 13, No. 15.
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Rothwell, J, Madrid-Gambin, F, Garcia-Aloy, M, Andres-Lacueva, C, Logue, C, Gallagher, AM, Mack, C, Kulling, SE, Gao, Q, Praticó, G, Dragsted, LO & Scalbert, A 2018, 'Biomarkers of intake for coffee, tea, and sweetened beverages', Genes and Nutrition, vol. 13, no. 15. https://doi.org/10.1186/s12263-018-0607-5

Biomarkers of intake for coffee, tea, and sweetened beverages. / Rothwell, Joseph ; Madrid-Gambin, Francisco; Garcia-Aloy, Mar; Andres-Lacueva, Cristina ; Logue, Caomhan; Gallagher, Alison M.; Mack, Carina; Kulling, Sabine E.; Gao, Qian ; Praticó, Giulia; Dragsted, Lars O.; Scalbert, Augustin.

In: Genes and Nutrition, Vol. 13, No. 15, 04.07.2018.

Research output: Contribution to journalReview article

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T1 - Biomarkers of intake for coffee, tea, and sweetened beverages

AU - Rothwell, Joseph

AU - Madrid-Gambin, Francisco

AU - Garcia-Aloy, Mar

AU - Andres-Lacueva, Cristina

AU - Logue, Caomhan

AU - Gallagher, Alison M.

AU - Mack, Carina

AU - Kulling, Sabine E.

AU - Gao, Qian

AU - Praticó, Giulia

AU - Dragsted, Lars O.

AU - Scalbert, Augustin

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N2 - Non-alcoholic beverages are important sources of nutrients and bioactive compounds that may influence human health and increase or decrease the risk of chronic diseases. A wide variety of beverage constituents are absorbed in the gut, found in the systemic circulation and excreted in urine. They may be used as compliance markers in intervention studies or as biomarkers of intake to improve measurements of beverage consumption in cohort studies and reveal new associations with disease outcomes that may have been overlooked when using dietary questionnaires. Here, biomarkers of intake of some major non-alcoholic beverages—coffee, tea, sugar-sweetened beverages, and low-calorie-sweetened beverages—are reviewed. Results from dietary intervention studies and observational studies are reviewed and analyzed, and respective strengths and weaknesses of the various identified biomarkers discussed. A variety of compounds derived from phenolic acids, alkaloids, and terpenes were shown to be associated with coffee intake and trigonelline and cyclo(isoleucylprolyl) showed a particularly high specificity for coffee intake. Epigallocatechin and 4′-O-methylepigallocatechin appear to be the most sensitive and specific biomarkers for green or black tea, while 4-O-methylgallic acid may be used to assess black tea consumption. Intake of sugar-sweetened beverages has been assessed through the measurement of carbon-13 enrichment of whole blood or of blood alanine in North America where sugar from sugarcane or corn is used as a main ingredient. The most useful biomarkers for low-calorie-sweetened beverages are the low-calorie sweeteners themselves. Further studies are needed to validate these biomarkers in larger and independent populations and to further evaluate their specificity, reproducibility over time, and fields of application.

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KW - Non-alcoholic beverages

KW - Coffee

KW - Tea

KW - Sugar-sweetened beverages

KW - Low-calorie sweetened beverages

KW - Biomarkers

KW - Intake

U2 - 10.1186/s12263-018-0607-5

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SN - 1555-8932

IS - 15

ER -