Biomarkers associated with sedentary behaviour in older adults: A systematic review

K. Wirth, J. Klenk, S. Brefka, D. Dallmeier, K. Faehling, M. Roqué i Figuls, M.A. Tully, M. Giné-Garriga, P. Caserotti, A. Salvà, D. Rothenbacher, M. Denkinger, B. Stubbs

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Objective
Pathomechanisms of sedentary behaviour (SB) are unclear. We conducted a systematic review to investigate the associations between SB and various biomarkers in older adults.

Methods
Electronic databases were searched (MEDLINE, EMBASE, CINAHL, AMED) up to July 2015 to identify studies with objective or subjective measures of SB, sample size ≥50, mean age ≥60 years and accelerometer wear time ≥3 days. Methodological quality was appraised with the CASP tool. The protocol was pre-specified (PROSPERO CRD42015023731).

Results
12701 abstracts were retrieved, 275 full text articles further explored, from which 249 were excluded. In the final sample (26 articles) a total of 63 biomarkers were detected. Most investigated markers were: body mass index (BMI, n = 15), waist circumference (WC, n = 15), blood pressure (n = 11), triglycerides (n = 12) and high density lipoprotein (HDL, n = 15). Some inflammation markers were identified such as interleukin-6, C-reactive protein or tumor necrosis factor alpha. There was a lack of renal, muscle or bone biomarkers. Randomized controlled trials found a positive correlation for SB with BMI, neck circumference, fat mass, HbA1C, cholesterol and insulin levels, cohort studies additionally for WC, leptin, C-peptide, ApoA1 and Low density lipoprotein and a negative correlation for HDL.

Conclusion
Most studied biomarkers associated with SB were of cardiovascular or metabolic origin. There is a suggestion of a negative impact of SB on biomarkers but still a paucity of high quality investigations exist. Longitudinal studies with objectively measured SB are needed to further elucidate the pathophysiological pathways and possible associations of unexplored biomarkers.

LanguageEnglish
Pages87-111
Number of pages25
JournalAgeing Research Reviews
Volume35
DOIs
Publication statusPublished - 23 Dec 2016

Fingerprint

Biomarkers
C-Peptide
Blood pressure
Waist Circumference
HDL Lipoproteins
Leptin
LDL Lipoproteins
Accelerometers
MEDLINE
C-Reactive Protein
Sample Size
Longitudinal Studies
Muscle
Interleukin-6
Bone
Triglycerides
Body Mass Index
Cohort Studies
Neck
Randomized Controlled Trials

Keywords

  • older adults
  • sedentary behaviour
  • biomarker

Cite this

Wirth, K., Klenk, J., Brefka, S., Dallmeier, D., Faehling, K., Roqué i Figuls, M., ... Stubbs, B. (2016). Biomarkers associated with sedentary behaviour in older adults: A systematic review. 35, 87-111. https://doi.org/10.1016/j.arr.2016.12.002
Wirth, K. ; Klenk, J. ; Brefka, S. ; Dallmeier, D. ; Faehling, K. ; Roqué i Figuls, M. ; Tully, M.A. ; Giné-Garriga, M. ; Caserotti, P. ; Salvà, A. ; Rothenbacher, D. ; Denkinger, M. ; Stubbs, B. / Biomarkers associated with sedentary behaviour in older adults: A systematic review. 2016 ; Vol. 35. pp. 87-111.
@article{661afbb578d244839f1c41f9c2089a1b,
title = "Biomarkers associated with sedentary behaviour in older adults: A systematic review",
abstract = "ObjectivePathomechanisms of sedentary behaviour (SB) are unclear. We conducted a systematic review to investigate the associations between SB and various biomarkers in older adults.MethodsElectronic databases were searched (MEDLINE, EMBASE, CINAHL, AMED) up to July 2015 to identify studies with objective or subjective measures of SB, sample size ≥50, mean age ≥60 years and accelerometer wear time ≥3 days. Methodological quality was appraised with the CASP tool. The protocol was pre-specified (PROSPERO CRD42015023731).Results12701 abstracts were retrieved, 275 full text articles further explored, from which 249 were excluded. In the final sample (26 articles) a total of 63 biomarkers were detected. Most investigated markers were: body mass index (BMI, n = 15), waist circumference (WC, n = 15), blood pressure (n = 11), triglycerides (n = 12) and high density lipoprotein (HDL, n = 15). Some inflammation markers were identified such as interleukin-6, C-reactive protein or tumor necrosis factor alpha. There was a lack of renal, muscle or bone biomarkers. Randomized controlled trials found a positive correlation for SB with BMI, neck circumference, fat mass, HbA1C, cholesterol and insulin levels, cohort studies additionally for WC, leptin, C-peptide, ApoA1 and Low density lipoprotein and a negative correlation for HDL.ConclusionMost studied biomarkers associated with SB were of cardiovascular or metabolic origin. There is a suggestion of a negative impact of SB on biomarkers but still a paucity of high quality investigations exist. Longitudinal studies with objectively measured SB are needed to further elucidate the pathophysiological pathways and possible associations of unexplored biomarkers.",
keywords = "older adults, sedentary behaviour, biomarker",
author = "K. Wirth and J. Klenk and S. Brefka and D. Dallmeier and K. Faehling and {Roqu{\'e} i Figuls}, M. and M.A. Tully and M. Gin{\'e}-Garriga and P. Caserotti and A. Salv{\`a} and D. Rothenbacher and M. Denkinger and B. Stubbs",
note = "cited By 15",
year = "2016",
month = "12",
day = "23",
doi = "10.1016/j.arr.2016.12.002",
language = "English",
volume = "35",
pages = "87--111",

}

Wirth, K, Klenk, J, Brefka, S, Dallmeier, D, Faehling, K, Roqué i Figuls, M, Tully, MA, Giné-Garriga, M, Caserotti, P, Salvà, A, Rothenbacher, D, Denkinger, M & Stubbs, B 2016, 'Biomarkers associated with sedentary behaviour in older adults: A systematic review', vol. 35, pp. 87-111. https://doi.org/10.1016/j.arr.2016.12.002

Biomarkers associated with sedentary behaviour in older adults: A systematic review. / Wirth, K.; Klenk, J.; Brefka, S.; Dallmeier, D.; Faehling, K.; Roqué i Figuls, M.; Tully, M.A.; Giné-Garriga, M.; Caserotti, P.; Salvà, A.; Rothenbacher, D.; Denkinger, M.; Stubbs, B.

Vol. 35, 23.12.2016, p. 87-111.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Biomarkers associated with sedentary behaviour in older adults: A systematic review

AU - Wirth, K.

AU - Klenk, J.

AU - Brefka, S.

AU - Dallmeier, D.

AU - Faehling, K.

AU - Roqué i Figuls, M.

AU - Tully, M.A.

AU - Giné-Garriga, M.

AU - Caserotti, P.

AU - Salvà, A.

AU - Rothenbacher, D.

AU - Denkinger, M.

AU - Stubbs, B.

N1 - cited By 15

PY - 2016/12/23

Y1 - 2016/12/23

N2 - ObjectivePathomechanisms of sedentary behaviour (SB) are unclear. We conducted a systematic review to investigate the associations between SB and various biomarkers in older adults.MethodsElectronic databases were searched (MEDLINE, EMBASE, CINAHL, AMED) up to July 2015 to identify studies with objective or subjective measures of SB, sample size ≥50, mean age ≥60 years and accelerometer wear time ≥3 days. Methodological quality was appraised with the CASP tool. The protocol was pre-specified (PROSPERO CRD42015023731).Results12701 abstracts were retrieved, 275 full text articles further explored, from which 249 were excluded. In the final sample (26 articles) a total of 63 biomarkers were detected. Most investigated markers were: body mass index (BMI, n = 15), waist circumference (WC, n = 15), blood pressure (n = 11), triglycerides (n = 12) and high density lipoprotein (HDL, n = 15). Some inflammation markers were identified such as interleukin-6, C-reactive protein or tumor necrosis factor alpha. There was a lack of renal, muscle or bone biomarkers. Randomized controlled trials found a positive correlation for SB with BMI, neck circumference, fat mass, HbA1C, cholesterol and insulin levels, cohort studies additionally for WC, leptin, C-peptide, ApoA1 and Low density lipoprotein and a negative correlation for HDL.ConclusionMost studied biomarkers associated with SB were of cardiovascular or metabolic origin. There is a suggestion of a negative impact of SB on biomarkers but still a paucity of high quality investigations exist. Longitudinal studies with objectively measured SB are needed to further elucidate the pathophysiological pathways and possible associations of unexplored biomarkers.

AB - ObjectivePathomechanisms of sedentary behaviour (SB) are unclear. We conducted a systematic review to investigate the associations between SB and various biomarkers in older adults.MethodsElectronic databases were searched (MEDLINE, EMBASE, CINAHL, AMED) up to July 2015 to identify studies with objective or subjective measures of SB, sample size ≥50, mean age ≥60 years and accelerometer wear time ≥3 days. Methodological quality was appraised with the CASP tool. The protocol was pre-specified (PROSPERO CRD42015023731).Results12701 abstracts were retrieved, 275 full text articles further explored, from which 249 were excluded. In the final sample (26 articles) a total of 63 biomarkers were detected. Most investigated markers were: body mass index (BMI, n = 15), waist circumference (WC, n = 15), blood pressure (n = 11), triglycerides (n = 12) and high density lipoprotein (HDL, n = 15). Some inflammation markers were identified such as interleukin-6, C-reactive protein or tumor necrosis factor alpha. There was a lack of renal, muscle or bone biomarkers. Randomized controlled trials found a positive correlation for SB with BMI, neck circumference, fat mass, HbA1C, cholesterol and insulin levels, cohort studies additionally for WC, leptin, C-peptide, ApoA1 and Low density lipoprotein and a negative correlation for HDL.ConclusionMost studied biomarkers associated with SB were of cardiovascular or metabolic origin. There is a suggestion of a negative impact of SB on biomarkers but still a paucity of high quality investigations exist. Longitudinal studies with objectively measured SB are needed to further elucidate the pathophysiological pathways and possible associations of unexplored biomarkers.

KW - older adults

KW - sedentary behaviour

KW - biomarker

UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85012285871&doi=10.1016%2fj.arr.2016.12.002&partnerID=40&md5=abc893164008ee914740da430373f7b8

U2 - 10.1016/j.arr.2016.12.002

DO - 10.1016/j.arr.2016.12.002

M3 - Article

VL - 35

SP - 87

EP - 111

ER -

Wirth K, Klenk J, Brefka S, Dallmeier D, Faehling K, Roqué i Figuls M et al. Biomarkers associated with sedentary behaviour in older adults: A systematic review. 2016 Dec 23;35:87-111. https://doi.org/10.1016/j.arr.2016.12.002