Bioassembled nanocircuits of Mo6S9-xIx nanowires for electrochemical immunodetection of estrone hapten

N Sun; M McMullan; P Papakonstantinou; H Gao; XX Zhang; D Mihailovic; MX Li

doi:10.1021/ac7024893

Bioassembled nanocircuits of Mo6S9-xIx nanowires for electrochemical immunodetection of estrone hapten

N Sun
, M McMullan
, P Papakonstantinou
, H Gao
, XX Zhang
, D Mihailovic
, MX Li

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

We demonstrate a novel and highly sensitive electrochemical detection of estrone based on an immunosensor platform, composed of bioassembled nanocircuits of Mo6S9-xIx nanowires (MoSI NWs) covalently connected to anti-estrone antibodies. The one-step, label-free, and quantitative detection of estrone is realized by employing the [Ru(NH3)(6)](3+/2+) redox ions to sense anti-estrone antibody and estrone interactions. The MoSI NWs/anti-estrone antibody nanocircuit architectures provide an amplification and conductive pathway for the specific electrochemical sensing of estrone hapten. A detection limit of 1.4 pg.mL(-1) was achieved in contrast to previous electrochemical techniques in which the sensitivity was limited to the nanomolar range.

Original language	English
Pages (from-to)	3593-3597
Journal	Analytical Chemistry
Volume	80
Issue number	10
DOIs	https://doi.org/10.1021/ac7024893
Publication status	Published (in print/issue) - 15 May 2008

Access to Document

10.1021/ac7024893

Cite this

@article{f1c728103aa94cd499b7ab5693151cf2,

title = "Bioassembled nanocircuits of Mo6S9-xIx nanowires for electrochemical immunodetection of estrone hapten",

abstract = "We demonstrate a novel and highly sensitive electrochemical detection of estrone based on an immunosensor platform, composed of bioassembled nanocircuits of Mo6S9-xIx nanowires (MoSI NWs) covalently connected to anti-estrone antibodies. The one-step, label-free, and quantitative detection of estrone is realized by employing the [Ru(NH3)(6)](3+/2+) redox ions to sense anti-estrone antibody and estrone interactions. The MoSI NWs/anti-estrone antibody nanocircuit architectures provide an amplification and conductive pathway for the specific electrochemical sensing of estrone hapten. A detection limit of 1.4 pg.mL(-1) was achieved in contrast to previous electrochemical techniques in which the sensitivity was limited to the nanomolar range.",

author = "N Sun and M McMullan and P Papakonstantinou and H Gao and XX Zhang and D Mihailovic and MX Li",

year = "2008",

month = may,

day = "15",

doi = "10.1021/ac7024893",

language = "English",

volume = "80",

pages = "3593--3597",

journal = "Analytical Chemistry",

issn = "1520-6882",

publisher = "American Chemical Society",

number = "10",

}

TY - JOUR

T1 - Bioassembled nanocircuits of Mo6S9-xIx nanowires for electrochemical immunodetection of estrone hapten

AU - Sun, N

AU - McMullan, M

AU - Papakonstantinou, P

AU - Gao, H

AU - Zhang, XX

AU - Mihailovic, D

AU - Li, MX

PY - 2008/5/15

Y1 - 2008/5/15

N2 - We demonstrate a novel and highly sensitive electrochemical detection of estrone based on an immunosensor platform, composed of bioassembled nanocircuits of Mo6S9-xIx nanowires (MoSI NWs) covalently connected to anti-estrone antibodies. The one-step, label-free, and quantitative detection of estrone is realized by employing the [Ru(NH3)(6)](3+/2+) redox ions to sense anti-estrone antibody and estrone interactions. The MoSI NWs/anti-estrone antibody nanocircuit architectures provide an amplification and conductive pathway for the specific electrochemical sensing of estrone hapten. A detection limit of 1.4 pg.mL(-1) was achieved in contrast to previous electrochemical techniques in which the sensitivity was limited to the nanomolar range.

AB - We demonstrate a novel and highly sensitive electrochemical detection of estrone based on an immunosensor platform, composed of bioassembled nanocircuits of Mo6S9-xIx nanowires (MoSI NWs) covalently connected to anti-estrone antibodies. The one-step, label-free, and quantitative detection of estrone is realized by employing the [Ru(NH3)(6)](3+/2+) redox ions to sense anti-estrone antibody and estrone interactions. The MoSI NWs/anti-estrone antibody nanocircuit architectures provide an amplification and conductive pathway for the specific electrochemical sensing of estrone hapten. A detection limit of 1.4 pg.mL(-1) was achieved in contrast to previous electrochemical techniques in which the sensitivity was limited to the nanomolar range.

U2 - 10.1021/ac7024893

DO - 10.1021/ac7024893

M3 - Article

SN - 1520-6882

VL - 80

SP - 3593

EP - 3597

JO - Analytical Chemistry

JF - Analytical Chemistry

IS - 10

ER -

Bioassembled nanocircuits of Mo6S9-xIx nanowires for electrochemical immunodetection of estrone hapten

Abstract

Access to Document

Fingerprint

Cite this