Bioassembled nanocircuits of Mo6S9-xIx nanowires for electrochemical immunodetection of estrone hapten

N Sun, M McMullan, P Papakonstantinou, H Gao, XX Zhang, D Mihailovic, MX Li

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

We demonstrate a novel and highly sensitive electrochemical detection of estrone based on an immunosensor platform, composed of bioassembled nanocircuits of Mo6S9-xIx nanowires (MoSI NWs) covalently connected to anti-estrone antibodies. The one-step, label-free, and quantitative detection of estrone is realized by employing the [Ru(NH3)(6)](3+/2+) redox ions to sense anti-estrone antibody and estrone interactions. The MoSI NWs/anti-estrone antibody nanocircuit architectures provide an amplification and conductive pathway for the specific electrochemical sensing of estrone hapten. A detection limit of 1.4 pg.mL(-1) was achieved in contrast to previous electrochemical techniques in which the sensitivity was limited to the nanomolar range.
LanguageEnglish
Pages3593-3597
JournalAnalytical Chemistry
Volume80
Issue number10
DOIs
Publication statusPublished - 15 May 2008

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Haptens
Estrone
Nanowires
Antibodies
Immunosensors
Amplification
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Ions

Cite this

Sun, N ; McMullan, M ; Papakonstantinou, P ; Gao, H ; Zhang, XX ; Mihailovic, D ; Li, MX. / Bioassembled nanocircuits of Mo6S9-xIx nanowires for electrochemical immunodetection of estrone hapten. In: Analytical Chemistry. 2008 ; Vol. 80, No. 10. pp. 3593-3597.
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Bioassembled nanocircuits of Mo6S9-xIx nanowires for electrochemical immunodetection of estrone hapten. / Sun, N; McMullan, M; Papakonstantinou, P; Gao, H; Zhang, XX; Mihailovic, D; Li, MX.

In: Analytical Chemistry, Vol. 80, No. 10, 15.05.2008, p. 3593-3597.

Research output: Contribution to journalArticle

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