Bioassembled nanocircuits of Mo6S9-xIx nanowires for electrochemical immunodetection of estrone hapten

N Sun, M McMullan, P Papakonstantinou, H Gao, XX Zhang, D Mihailovic, MX Li

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

We demonstrate a novel and highly sensitive electrochemical detection of estrone based on an immunosensor platform, composed of bioassembled nanocircuits of Mo6S9-xIx nanowires (MoSI NWs) covalently connected to anti-estrone antibodies. The one-step, label-free, and quantitative detection of estrone is realized by employing the [Ru(NH3)(6)](3+/2+) redox ions to sense anti-estrone antibody and estrone interactions. The MoSI NWs/anti-estrone antibody nanocircuit architectures provide an amplification and conductive pathway for the specific electrochemical sensing of estrone hapten. A detection limit of 1.4 pg.mL(-1) was achieved in contrast to previous electrochemical techniques in which the sensitivity was limited to the nanomolar range.
Original languageEnglish
Pages (from-to)3593-3597
JournalAnalytical Chemistry
Volume80
Issue number10
DOIs
Publication statusPublished - 15 May 2008

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